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Mesenchymal stem cells. --- Bone marrow stromal cells --- Marrow stromal cells --- MSCs (Mesenchymal stem cells) --- Stromal cells, Bone marrow --- Stromal cells, Marrow --- Multipotent stem cells

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Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD). This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation.

Inflammation. --- Mesenchymal stem cells --- Bone marrow stromal cells --- Marrow stromal cells --- MSCs (Mesenchymal stem cells) --- Stromal cells, Bone marrow --- Stromal cells, Marrow --- Multipotent stem cells --- Inflammatory process --- Pathology --- Anti-inflammatory agents --- Transplantation. --- Autoimmune Disorders. --- Immunomodulation. --- Regenerative Medicine. --- Stem Cells.

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This book explores dental stem cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for regenerative medicine. The first seven chapters delve into basic DSC properties, vital signaling pathways involved in differentiation, pluripotency, iPS cell development from DSCs, and genetic engineering approaches of DSCs in accordance with the current literature. A comprehensive review of possible clinical applications and in vitro/in vivo studies follows, illustrating the future of DSC research for in the tissue engineering field. The text also discusses the political, ethical, social, and legal ramifications of the use of dental stem cells. Expertly authored and drawing from a multitude of international perspectives, Dental Stem Cells is an invaluable addition to Springer's Stem Cell Biology and Regenerative Medicine series. It is essential reading for advanced graduate students, basic researchers, and clinical investigators in the fields of stem cell therapy, biological sciences of dentistry, and regenerative medicine.

Life sciences. --- Stem cells. --- Regenerative medicine. --- Tissue engineering. --- Life Sciences. --- Stem Cells. --- Regenerative Medicine/Tissue Engineering. --- Mesenchymal stem cells. --- Bone marrow stromal cells --- Marrow stromal cells --- MSCs (Mesenchymal stem cells) --- Stromal cells, Bone marrow --- Stromal cells, Marrow --- Multipotent stem cells --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Medicine --- Regeneration (Biology)

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Mesenchymal stem cells. --- Veterinary medicine. --- Farriery --- Large animal medicine --- Large animal veterinary medicine --- Livestock medicine --- Veterinary science --- Medicine --- Animal health --- Animals --- Domestic animals --- Livestock --- Bone marrow stromal cells --- Marrow stromal cells --- MSCs (Mesenchymal stem cells) --- Stromal cells, Bone marrow --- Stromal cells, Marrow --- Multipotent stem cells --- Diseases --- Losses

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I. Eberle M. Moslem R. Henschler T. Cantz Engineered MSCs from Patient-Specific iPS Cells B. Wagner R. Henschler Fate of Intravenously Injected Mesenchymal Stem Cells and Significance for Clinical Application M. L. Lim P. Jungebluth P. Macchiarini The Implications of Stem Cell Applications for Diseases of the Respiratory System B. Weyand P. M. Vogt Potential of Mesenchymal Stem Cell Applications in Plastic and Reconstructive Surgery M. Jagodzinski C. Haasper General Principles for the Regeneration of Bone and Cartilage K. M. Fawzy El-Sayed C. Dörfer F. Fändrich F. Gieseler M. H. Moustafa H. Ungefroren Adult Mesenchymal Stem Cells Explored in the Dental Field K. M. Akram S. Samad M. Spiteri, N. R. Forsyth Mesenchymal Stem Cell Therapy and Lung Diseases C. Papewalis D. Topolar B. Götz S. Schönberger D. Dilloo Mesenchymal Stem Cells as Cellular Immunotherapeutics in Allogeneic Hematopoietic Stem Cell Transplantation   A. M. Betancourt New Cell-Based Therapy Paradigm: Induction of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells into Pro-Inflammatory MSC1 and Anti-inflammatory MSC2 Phenotypes G. Maria Spaggiari L. Moretta Interactions Between Mesenchymal Stem Cells and Dendritic Cells N. D’souza, J. Sans Burns G. Grisendi O. Candini E. Veronesi S. Piccinno E. M. Horwitz P. Paolucci P. Conte M. Dominici MSC and Tumors: Homing, Differentiation, and Secretion Influence Therapeutic Potential M. Pozzobon M. Piccoli P. De Coppi Sources of Mesenchymal Stem Cells: Current and Future Clinical Use G. Migliaccio C. Pintus Role of the EU Framework in Regulation of Stem Cell-Based Products.

Chemistry. --- Medicine. --- Biochemical engineering. --- Stem cells. --- Biochemical Engineering. --- Stem Cells. --- Biomedicine general. --- Health & Biological Sciences --- Biomedical Engineering --- Bio-process engineering --- Bioprocess engineering --- Clinical sciences --- Medical profession --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Biochemistry --- Biotechnology --- Chemical engineering --- Cells --- Physical sciences --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Mesenchymal stem cells. --- Bone marrow stromal cells --- Marrow stromal cells --- MSCs (Mesenchymal stem cells) --- Stromal cells, Bone marrow --- Stromal cells, Marrow --- Multipotent stem cells --- Biomedicine, general. --- Chemistry --- Medicine --- Biochemical engineering --- Stem cells