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Cancer --- Diagnosis. --- Càncer. --- Marcadors bioquímics --- Diagnòstic

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Biochemical markers. --- Biochemical markers --- Evaluation. --- Biologic markers --- Biological markers --- Biomarkers --- Markers, Biochemical --- Biochemistry --- Indicators (Biology) --- Marcadors bioquímics --- Nutrició

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This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike. .

General biochemistry --- Physiology: reproduction & development. Ages of life --- Geriatrics --- veroudering (biologie) --- biochemie --- geriatrie --- Biochemical markers. --- Oxidation-reduction reaction. --- Aging --- Molecular aspects. --- Vellesa --- Marcadors bioquímics --- Oxidació fisiològica --- Reacció d'oxidació-reducció --- Molecular aspects

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Translational Urinomics provides an overview of urine analysis using proteomics, metabolomics, transcriptomics or any combination thereof for the diagnosis and prognosis of diseases related to the urinary system and the kidneys. The text approaches urine biomarkers from a new perspective, incorporating up-to-date studies of mass-spectrometry-based biomarker discovery as well as the latest advances in personalized medicine. The integration of technology-driven techniques, such as OMICS also provides a unique opportunity for improved diagnostics accuracy of urinary-related diseases. For nephrologists and urologists looking for new approaches to well-known problems, this edited volume serves as a valuable guide.

Proteomics. --- Metabolism. --- Genetics. --- Urology. --- Nephrology. --- Cancer research. --- Metabolomics. --- Genetics and Genomics. --- Cancer Research. --- Cancer research --- Internal medicine --- Kidneys --- Medicine --- Genitourinary organs --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Molecular biology --- Proteins --- Diseases --- Urine --- Analysis. --- Diagnosis, Urinary --- Urinalysis --- Urine in disease --- Clinical chemistry --- Analysis and pathology --- Fermentation and ferments --- Pathology --- Semiology --- Tests --- Examination --- Anàlisi d'orina --- Marcadors bioquímics

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Càncer de bufeta --- Diagnòstic per la imatge --- Marcadors bioquímics --- Bladder --- Cancer --- Diagnosis. --- Biomarcadors --- Marcadors biològics --- Bioquímica --- Indicadors biològics --- Marcadors genètics --- Marcadors tumorals --- Neopterina --- Diagnòstic per imatge --- Diagnòstic per imatgeria --- Imatgeria per al diagnòstic --- Imatges diagnòstiques --- Imatges per al diagnòstic --- Diagnòstic --- Imatges mèdiques --- Diagnòstic radiològic --- Ecografia --- Endoscòpia --- Gammagrafia --- Imatges per ressonància magnètica --- Termografia mèdica --- Tomografia per emissió de positrons --- Substàncies de contrast --- Càncer de bufeta urinària --- Càncer --- Urinary Bladder Neoplasms --- diagnosis. --- diagnostic imaging.