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The mortality from ischemic heart disease has decreased in recent years. The better understanding of risk factors associated with development of coronary artery disease has significantly contributed to this decline. Improvements in medical and interventional therapy have reduced the complications associated with acute myocardial infarction as well as revascularization. After the introduction of imaging modalities, the noninvasive characterization of regional function, perfusion and metabolism allowed for more sophisticated tissue characterization to identify reversible dysfunction with high diagnostic and prognostic accuracy. We now can legitimately claim that computed tomography angiography (CTA) of the coronary arteries is available. In the evaluation of patients with suspected coronary artery disease, many guidelines today consider CTA an alternative to stress testing. However the nuclear technique most frequently used by cardiologists is myocardial perfusion imaging (MPI). The combination of a nuclear camera with CTA allows for the attainment of coronary anatomic, cardiac function and MPI from one piece of equipment. Assessing cardiac viability is now fairly routine with these enhancements to cardiac imaging. Traditional coronary angiography presents a variety of limitations related to image acquisition, content, interpretation, and patient safety. Barriers to such improvements include the paucity of clinical outcomes studies related to new imaging technology, the need for physician and staff member training, and the costs associated with acquiring and effectively using these advances in coronary angiography. This issue is full of important information that every cardiologist needs to now.

Myocardial reperfusion. --- Reperfusion (Physiology) --- Cardiovascular medicine

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FRANCE --- MYOCARDIAL REPERFUSION INJURY --- HISTOIRE CONSTITUTIONNELLE --- CONGRESSES --- 10E-15E SIECLES

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Quatrième de couverture : "La survenue d'une thrombose coronaire aigüe engendre une ischémie myocardique immédiate : plus elle se prolonge, plus le volume de tissu détruit augmente : les techniques de désobstruction ont permis de diviser par 5 le nombre de décès précoces. Toutefois, l'ischémie partage la responsabilité de la destruction des cellules endothéliales et myocardiques avec les lésions spécifiques consécutives à la désobstruction du vaisseau épicardique occlus qui pourrait se rendre responsables de 50% de la perte cellulaire. La nécrose myocardique est une terme inadapté. Elle correspond à la phase cicatricielle des éléments détruits. L'oncose, l'apoptose et l'autophagie se partagent les mécanismes délétères. La protection des cellules cardiaques peut être espérée au terme des stratégies de conditionnement (préconditionnement, spontané, postconditionnement, au cours de l'angioplastie) et de protection pharmacologique. L'auteur a consacré ses travaux de recherche à ce thème majeur et propose des alternatives à la technique d'angioplastie primaire conventionnelle. Cet ouvrage, fruit d'une longue pratique et d'une recherche abondante, offre au lecteur une synthèse exhaustive sur le fonctionnement normal de la cellule myocardique, sur les mécanismes de morts cellulaires, sur les méthodes de protection et enfin sur de nouvelles stratégies de reperfusion efficaces (en chirurgie cardiaque et au cours de l'infarctus avec sus-décalage de ST)."

Myocardial Infarction --- Myocardial Ischemia --- Myocardial Reperfusion --- Ischémie myocardique. --- Reperfusion myocardique. --- Infarctus du myocarde. --- Myocardial infarction --- Coronary heart disease --- Myocardial reperfusion --- Myocardial Ischemia.

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Allopurinol --- Reperfusion Injury --- Thoracic Surgery --- Myocardial Reperfusion Injury --- pharmacology --- prevention & control

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Apoptosis --- Cell Membrane --- Image Processing, Computer-Assisted --- Myocardial Reperfusion Injury --- Myocardium --- Heart --- physiology --- pathology --- methods --- physiopathology