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Gallbladder Emptying --- Gastric Emptying --- Motilin --- Gallbladder --- drug effects --- pharmacology
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Ghrelin. --- Gastrointestinal hormones. --- Endocrinological gastroenterology --- Gut hormones --- Regulatory gut peptides --- RGP (Hormones) --- Hormones --- Motilin-related peptide --- Gastrointestinal hormones --- Peptide hormones
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The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson’s disease, epilepsy, anxiety and depression.
Ghrelin --- Peptide hormones --- Physiological effect. --- Receptors. --- Motilin-related peptide --- Gastrointestinal hormones --- Neurosciences. --- Neurochemistry. --- Biochemistry --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system
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CALCIBONIN --- CATECHOLAMINES --- TSH --- VITAMINE D --- CHORIONIC GONADOTROPHIN --- DOPAMINE --- GASTRIC INHIBITORY PEPTIDE --- HORMONES GASTRO-INTESTINAL --- IMMUNOASSAY --- MOTILIN --- NORADRENALINE --- PANCRATIC POLYPEPTIDE --- SEROTONIN --- ERYTHROPOIETIN --- GLUCAGON --- GONADOTROPHINS --- GROWTH HORMONE --- INSULIN --- IODINE --- LACTOGENIC HORMONE --- LIQUID CHROMATOGRAPHY --- LIPOTROPHIN --- PROLACTIN --- PROSTAGLANDINS --- SOMATOMEDINS --- SOMATOSTATIN --- THYROTROPIN
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PEPTIDE RECEPTOR LIGAND DRUGS --- NARCOTIC ANALGESICS --- CHOLINERGIC AGENTS --- NEUROMUSCULAR BLOCKERS --- ENZYMES-SUBSTRATES INHIBITORS --- ASTHMA --- PHOSPHODIESTERASE INHIBITORS --- OPIOID PEPTIDES --- NEUROKININS --- VASOPRESSIN --- OXYTOCIN --- ASPERLICIN --- BENZODIAZEPINES --- SOMATOSTATIN --- GASTRIN-RELEASING PEPTIDE --- BOMBESIN --- MOTILIN --- LUTEOLYTIC AGENTS --- FERTILITY REGULATION --- CALCIUM CHANNELS --- DIURETICS, THIAZIDE --- INSULIN --- ANTITUMOR AGENTS --- ANTIVIRAL AGENTS --- QUINOLONE ANTIBACTERIALS --- ANTIBIOTICS, LACTAM --- CALCIUM --- ALDOSE REDUCTASE INHIBITORS --- THERAPEUTIC USE --- ANALOGS --- ENGINEERING --- CELLULAR SIGNIFICANCE
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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The volume covers ghrelin, and has chapters on such topics as orphan gpcrs and methods for identifying their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice. Contains quality chapters authored by leaders in the field Has chapters on such topics as orphan gpcrs and methods for identifying their ligands, ghrelin o-acyltransferase assays an
Ghrelin -- Physiological effect. --- Ghrelin. --- Growth hormone. --- Peptide Hormones --- Investigative Techniques --- Peptides --- Hormones --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Amino Acids, Peptides, and Proteins --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Chemicals and Drugs --- Chemistry Techniques, Analytical --- Ghrelin --- Chemistry Techniques, Analytical. --- Enzymes. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biocatalysts --- Ferments --- Soluble ferments --- Motilin-related peptide --- Composition --- Biology --- Chemistry --- Medical sciences --- Catalysts --- Proteins --- Enzymology --- Gastrointestinal hormones --- Peptide hormones
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Research during the past decade highlights the strong link between appetitive feeding behavior, reward and motivation. Interestingly, stress levels can affect feeding behavior by manipulating hypothalamic circuits and brain dopaminergic reward pathways. Indeed, animals and people will increase or decrease their feeding responses when stressed. In many cases acute stress leads to a decrease in food intake, yet chronic social stressors are associated to increases in caloric intake and adiposity. Interestingly, mood disorders and the treatments used to manage these disorders are also associated with changes in appetite and body weight. These data suggest a strong interaction between the systems that regulate feeding and metabolism and those that regulate mood. This Research Topic aims to illustrate how hormonal mechanisms regulate the nexus between feeding behavior and stress. It focuses on the hormonal regulation of hypothalamic circuits and/or brain dopaminergic systems, as the potential sites controlling the converging pathways between feeding behavior and stress.
Neuroendocrinology. --- Paraneurons. --- Stress (Physiology) --- Obesity --- Dopamine. --- Ghrelin. --- Leptin. --- Neuroscience --- Human Anatomy & Physiology --- Health & Biological Sciences --- Endocrine aspects. --- Hormonal aspects of physiological stress --- Endocrinology --- Neuroendocrine cells --- Neurons --- Chromaffin cells --- Neurology --- Neurohormones --- Adiposity --- Corpulence --- Fatness --- Overweight --- Body weight --- Metabolism --- Nutrition disorders --- Ob protein --- Hormones --- Motilin-related peptide --- Gastrointestinal hormones --- Peptide hormones --- Biogenic amines --- Bromocriptine --- Catecholamines --- Neurotransmitters --- Hormonal aspects --- Disorders --- stress --- Dopamine --- Ghrelin --- Leptin --- Seasonal regulation --- feeding --- HPA axis --- Hypothalamus --- circadian rhythms
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Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.
Nutrition Therapy. --- Palliative treatment. --- Terminal care. --- Ghrelin --- Metabolic Phenomena --- Peptide Hormones --- Biological Science Disciplines --- Hormones --- Peptides --- Phenomena and Processes --- Natural Science Disciplines --- Disciplines and Occupations --- Amino Acids, Peptides, and Proteins --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Chemicals and Drugs --- Physiology --- Metabolism --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Clinical Endocrinology --- Physiological aspects --- Ghrelin. --- Motilin-related peptide --- Medicine. --- Immunology. --- Neurosciences. --- Nutrition. --- Endocrinology. --- Geriatrics. --- Medicine & Public Health. --- Geriatrics/Gerontology. --- Gastrointestinal hormones --- Peptide hormones --- Alimentation --- Food --- Nutrition --- Health --- Diet --- Dietetics --- Digestion --- Food habits --- Malnutrition --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Immunobiology --- Life sciences --- Serology --- Gerontology --- Older people --- Internal medicine --- Health aspects --- Diseases --- Health and hygiene --- Endocrinology . --- Nutrition .
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