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Microcirculation.

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Microcirculation

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Microcirculation

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This dissertation by Alexandra Högstedt explores the microvascular effects of insulin in the skin, focusing on the interplay between glucose metabolism and microvascular function. The research aims to develop an in vivo model to study metabolic and microvascular responses to insulin, utilizing microdialysis techniques for local drug delivery and monitoring. The study investigates the impact of insulin on skin blood flow and metabolism, highlighting the role of the nitric oxide pathway and interactions with other physiological systems such as the renin-angiotensin system. It provides insight into microvascular dysfunction related to insulin resistance and proposes future applications for assessing insulin effects in various patient groups.

Insulin. --- Microcirculation.

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This dissertation by Hanna Jonasson presents a model-based quantitative assessment of skin blood flow and oxygen saturation using combined diffuse reflectance spectroscopy (DRS) and laser Doppler flowmetry (LDF). The research aims to develop an optical method for accurately measuring oxygen saturation, red blood cell (RBC) tissue fraction, and speed-resolved perfusion in absolute units. The study evaluates different calibration methods and model assumptions in optical phantoms and skin measurements. The integrated system demonstrates potential clinical applications for assessing microvascular function in both healthy individuals and patients with type 2 diabetes, showing reduced RBC tissue fraction and nutritive blood flow in patients compared to controls.

Microcirculation. --- Blood flow. --- Microcirculation --- Blood flow