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In 2007, Jeremy Jass proposed a molecular classification of colorectal cancer including KRAS, BRAF, Mismatch Repair, CIMP and MGMT Status. Since then, many prognostic and predictive studies have been published on this topic, mainly focusing on one single molecular marker. The aim of the e-book is to summarize the knowledge in 2014 from a multidisciplinary point of view that can potentially be used as a manual by CRC researchers in every field.
Colon (Anatomy) --- Rectum --- Molecular classification --- colorectal cancer --- Cdx2 --- MGMT --- ras signaling pathway --- microRNA --- Wnt Signaling Pathway --- telomere length --- Cancer. --- Cancer. --- Molecular classification --- colorectal cancer --- Cdx2 --- MGMT --- ras signaling pathway --- microRNA --- Wnt Signaling Pathway --- telomere length
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In 2007, Jeremy Jass proposed a molecular classification of colorectal cancer including KRAS, BRAF, Mismatch Repair, CIMP and MGMT Status. Since then, many prognostic and predictive studies have been published on this topic, mainly focusing on one single molecular marker. The aim of the e-book is to summarize the knowledge in 2014 from a multidisciplinary point of view that can potentially be used as a manual by CRC researchers in every field.
Colon (Anatomy) --- Rectum --- Cancer. --- Cancer. --- Molecular classification --- colorectal cancer --- Cdx2 --- MGMT --- ras signaling pathway --- microRNA --- Wnt Signaling Pathway --- telomere length
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In 2007, Jeremy Jass proposed a molecular classification of colorectal cancer including KRAS, BRAF, Mismatch Repair, CIMP and MGMT Status. Since then, many prognostic and predictive studies have been published on this topic, mainly focusing on one single molecular marker. The aim of the e-book is to summarize the knowledge in 2014 from a multidisciplinary point of view that can potentially be used as a manual by CRC researchers in every field.
Colon (Anatomy) --- Rectum --- Cancer. --- Molecular classification --- colorectal cancer --- Cdx2 --- MGMT --- ras signaling pathway --- microRNA --- Wnt Signaling Pathway --- telomere length
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mgmt.design --- Orntoft Peter --- Franchi Francesco --- relajaelcoco --- Derek Kim --- Grafische vormgeving ; visualisering kwantitatieve informatie --- Grafische vormgeving ; informatieweergave --- Grafieken ; statistieken --- Infografieken --- Infographics --- Gebruiksgrafiek ; voorlichting ; adviezen --- visualisatie (informatica) --- visualization [computer] --- digitale vormgeving --- Graphic arts --- ontwerpen --- Artificial intelligence. Robotics. Simulation. Graphics --- design [discipline] --- visuele communicatie --- grafisch ontwerp --- grafisch design --- grafische vormgeving --- 766.022 --- informatiedesign --- 766:659.2 --- Visuele communicatie --- 766.32.044 --- Grafische industrie en ontwerp ; beeld ; illustratie ; thema's ; infographics
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MicroRNAs are the best representatives of the non-coding part of the genome and their functions are mostly linked to their target genes. During the process of carcinogenesis, both dysregulation of microRNAs and their target genes can explain the development of the disease. However, most of the target genes of microRNAs have not yet been elucidated. In this book, we add new information related to the functions of microRNAs in various tumors and their associated targetome.
miR526b --- miR655 --- breast cancer --- angiogenesis --- lymphangiogenesis --- EP4 --- PI3K/Akt --- microRNA-361 --- EMT --- tumor microenvironment --- cancer diagnosis --- cancer treatment --- Bladder cancer --- microRNA --- genetic marker --- progression --- ccRCC --- prognostic biomarker --- miRNA --- transcription factor --- interplay --- microRNAs --- exosomes --- liquid biopsy --- metastasis --- cancer --- liquid biopsies --- tumor --- SNAIL (SNAI1) transcription factor --- epithelial to mesenchymal transition (EMT) --- long non-coding RNAs (lncRNAs) --- circular RNAs --- viral miRNAs --- EBV --- HHV-8 --- HPV --- HCV --- HBV --- MCPyV --- glioblastoma --- MGMT --- survival --- radiotherapy --- chemotherapy --- temozolomide --- translational medicine --- oncomiRNA --- post-transcriptional regulation --- immune regulation --- adrenocortical carcinoma --- micro RNA --- non-coding RNA --- thyroid carcinoma --- radioactive iodine --- drug resistance --- prognosis --- Burkitt lymphoma --- miR-378a-3p --- cell growth --- pancreatic cancer --- radioresistance --- personalized medicine --- biomarker --- target --- n/a
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MicroRNAs are the best representatives of the non-coding part of the genome and their functions are mostly linked to their target genes. During the process of carcinogenesis, both dysregulation of microRNAs and their target genes can explain the development of the disease. However, most of the target genes of microRNAs have not yet been elucidated. In this book, we add new information related to the functions of microRNAs in various tumors and their associated targetome.
Medicine --- Oncology --- miR526b --- miR655 --- breast cancer --- angiogenesis --- lymphangiogenesis --- EP4 --- PI3K/Akt --- microRNA-361 --- EMT --- tumor microenvironment --- cancer diagnosis --- cancer treatment --- Bladder cancer --- microRNA --- genetic marker --- progression --- ccRCC --- prognostic biomarker --- miRNA --- transcription factor --- interplay --- microRNAs --- exosomes --- liquid biopsy --- metastasis --- cancer --- liquid biopsies --- tumor --- SNAIL (SNAI1) transcription factor --- epithelial to mesenchymal transition (EMT) --- long non-coding RNAs (lncRNAs) --- circular RNAs --- viral miRNAs --- EBV --- HHV-8 --- HPV --- HCV --- HBV --- MCPyV --- glioblastoma --- MGMT --- survival --- radiotherapy --- chemotherapy --- temozolomide --- translational medicine --- oncomiRNA --- post-transcriptional regulation --- immune regulation --- adrenocortical carcinoma --- micro RNA --- non-coding RNA --- thyroid carcinoma --- radioactive iodine --- drug resistance --- prognosis --- Burkitt lymphoma --- miR-378a-3p --- cell growth --- pancreatic cancer --- radioresistance --- personalized medicine --- biomarker --- target --- miR526b --- miR655 --- breast cancer --- angiogenesis --- lymphangiogenesis --- EP4 --- PI3K/Akt --- microRNA-361 --- EMT --- tumor microenvironment --- cancer diagnosis --- cancer treatment --- Bladder cancer --- microRNA --- genetic marker --- progression --- ccRCC --- prognostic biomarker --- miRNA --- transcription factor --- interplay --- microRNAs --- exosomes --- liquid biopsy --- metastasis --- cancer --- liquid biopsies --- tumor --- SNAIL (SNAI1) transcription factor --- epithelial to mesenchymal transition (EMT) --- long non-coding RNAs (lncRNAs) --- circular RNAs --- viral miRNAs --- EBV --- HHV-8 --- HPV --- HCV --- HBV --- MCPyV --- glioblastoma --- MGMT --- survival --- radiotherapy --- chemotherapy --- temozolomide --- translational medicine --- oncomiRNA --- post-transcriptional regulation --- immune regulation --- adrenocortical carcinoma --- micro RNA --- non-coding RNA --- thyroid carcinoma --- radioactive iodine --- drug resistance --- prognosis --- Burkitt lymphoma --- miR-378a-3p --- cell growth --- pancreatic cancer --- radioresistance --- personalized medicine --- biomarker --- target
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Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers used for producing therapeutic devices, such as drug carriers (DC). PLGA is one of the few polymers that the Food and Drug Administration (FDA) has approved for human administration due to its biocompatibility and biodegradability. In recent years, DC produced with PLGA has gained enormous attention for its versatility in transporting different type of drugs, e.g., hydrophilic or hydrophobic small molecules, or macromolecules with a controlled drug release without modifying the physiochemical properties of the drugs. These drug delivery systems have the possibility/potential to modify their surface properties with functional groups, peptides, or other coatings to improve the interactions with biological materials. Furthermore, they present the possibility to be conjugated with specific target molecules to reach specific tissues or cells. They are also used for different therapeutic applications, such as in vaccinations, cancer treatment, neurological disorder treatment, and as anti-inflammatory agents. This book aims to focus on the recent progress of PLGA as a drug carrier and their new pharmaceutical applications.
Medicine --- PLGA --- nanoscaled drug delivery --- LED --- cancer --- serum stability --- reactive oxygen species --- cellular uptake --- terahertz spectroscopy --- microspheres --- drug delivery --- formulation development --- molecular mobility --- vitamin E --- tocopherol --- PLA --- core-shell nanoparticles --- controlled drug release --- BMP-2 --- PLGA nanoparticles --- Pluronic F68 --- oxaliplatin --- hydrogel --- intra-abdominal anti-adhesion barrier --- colorectal cancer --- experimental design --- fractional factorial design --- O6-methylguanine DNA methyltransferase (MGMT) protein --- glioblastoma multiforme --- smart nanocarriers --- folic acid --- verteporfin --- cisplatin --- SKOV-3 cells --- CHO-K1 cells --- electroporation --- theranostic cargo --- double emulsion approach --- NSAIDs --- polymeric film --- topical drug delivery --- trolamine salicylate --- triamcinolone acetonide --- microcrystal --- PLGA microsphere --- local delivery --- spray-drying technique --- intra-articular injection --- joint retention --- systemic exposure --- gadolinium --- drug release --- polymeric nanocarrier --- sorafenib --- theranostic nanoparticles --- PLGA-PEG --- nanoparticles --- platelet --- activation --- aggregation --- binding --- uptake --- tissue engineering --- Huntington's disease --- siRNA --- microcarriers --- mesenchymal stromal cells --- drug delivery systems --- microfluidics --- microparticles --- BMP-2-microspheres --- hydrogel system --- 17-βestradiol release --- bone regeneration --- osteoporosis --- poly-lactide-co-glycolide --- polylactic acid --- alginate --- ophthalmic drug delivery --- dexamethasone --- PLGA-NPs --- nanomedicine --- gastrointestinal tract --- paclitaxel --- in vivo imaging --- controlled release --- risperidone --- microcapsules --- oleogels --- electron microscopy --- three-dimensional X-ray imaging --- nano-CT --- biodegradable polymers --- hydroxy-stearic acid --- PLGA nanocapsules --- magnetic resonance imaging --- photoluminescence --- magnetic targeting --- multimodal imaging --- theranostics --- silicon --- microsphere --- PLGA --- nanoscaled drug delivery --- LED --- cancer --- serum stability --- reactive oxygen species --- cellular uptake --- terahertz spectroscopy --- microspheres --- drug delivery --- formulation development --- molecular mobility --- vitamin E --- tocopherol --- PLA --- core-shell nanoparticles --- controlled drug release --- BMP-2 --- PLGA nanoparticles --- Pluronic F68 --- oxaliplatin --- hydrogel --- intra-abdominal anti-adhesion barrier --- colorectal cancer --- experimental design --- fractional factorial design --- O6-methylguanine DNA methyltransferase (MGMT) protein --- glioblastoma multiforme --- smart nanocarriers --- folic acid --- verteporfin --- cisplatin --- SKOV-3 cells --- CHO-K1 cells --- electroporation --- theranostic cargo --- double emulsion approach --- NSAIDs --- polymeric film --- topical drug delivery --- trolamine salicylate --- triamcinolone acetonide --- microcrystal --- PLGA microsphere --- local delivery --- spray-drying technique --- intra-articular injection --- joint retention --- systemic exposure --- gadolinium --- drug release --- polymeric nanocarrier --- sorafenib --- theranostic nanoparticles --- PLGA-PEG --- nanoparticles --- platelet --- activation --- aggregation --- binding --- uptake --- tissue engineering --- Huntington's disease --- siRNA --- microcarriers --- mesenchymal stromal cells --- drug delivery systems --- microfluidics --- microparticles --- BMP-2-microspheres --- hydrogel system --- 17-βestradiol release --- bone regeneration --- osteoporosis --- poly-lactide-co-glycolide --- polylactic acid --- alginate --- ophthalmic drug delivery --- dexamethasone --- PLGA-NPs --- nanomedicine --- gastrointestinal tract --- paclitaxel --- in vivo imaging --- controlled release --- risperidone --- microcapsules --- oleogels --- electron microscopy --- three-dimensional X-ray imaging --- nano-CT --- biodegradable polymers --- hydroxy-stearic acid --- PLGA nanocapsules --- magnetic resonance imaging --- photoluminescence --- magnetic targeting --- multimodal imaging --- theranostics --- silicon --- microsphere
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Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers used for producing therapeutic devices, such as drug carriers (DC). PLGA is one of the few polymers that the Food and Drug Administration (FDA) has approved for human administration due to its biocompatibility and biodegradability. In recent years, DC produced with PLGA has gained enormous attention for its versatility in transporting different type of drugs, e.g., hydrophilic or hydrophobic small molecules, or macromolecules with a controlled drug release without modifying the physiochemical properties of the drugs. These drug delivery systems have the possibility/potential to modify their surface properties with functional groups, peptides, or other coatings to improve the interactions with biological materials. Furthermore, they present the possibility to be conjugated with specific target molecules to reach specific tissues or cells. They are also used for different therapeutic applications, such as in vaccinations, cancer treatment, neurological disorder treatment, and as anti-inflammatory agents. This book aims to focus on the recent progress of PLGA as a drug carrier and their new pharmaceutical applications.
PLGA --- nanoscaled drug delivery --- LED --- cancer --- serum stability --- reactive oxygen species --- cellular uptake --- terahertz spectroscopy --- microspheres --- drug delivery --- formulation development --- molecular mobility --- vitamin E --- tocopherol --- PLA --- core-shell nanoparticles --- controlled drug release --- BMP-2 --- PLGA nanoparticles --- Pluronic F68 --- oxaliplatin --- hydrogel --- intra-abdominal anti-adhesion barrier --- colorectal cancer --- experimental design --- fractional factorial design --- O6-methylguanine DNA methyltransferase (MGMT) protein --- glioblastoma multiforme --- smart nanocarriers --- folic acid --- verteporfin --- cisplatin --- SKOV-3 cells --- CHO-K1 cells --- electroporation --- theranostic cargo --- double emulsion approach --- NSAIDs --- polymeric film --- topical drug delivery --- trolamine salicylate --- triamcinolone acetonide --- microcrystal --- PLGA microsphere --- local delivery --- spray-drying technique --- intra-articular injection --- joint retention --- systemic exposure --- gadolinium --- drug release --- polymeric nanocarrier --- sorafenib --- theranostic nanoparticles --- PLGA-PEG --- nanoparticles --- platelet --- activation --- aggregation --- binding --- uptake --- tissue engineering --- Huntington’s disease --- siRNA --- microcarriers --- mesenchymal stromal cells --- drug delivery systems --- microfluidics --- microparticles --- BMP-2-microspheres --- hydrogel system --- 17-βestradiol release --- bone regeneration --- osteoporosis --- poly-lactide-co-glycolide --- polylactic acid --- alginate --- ophthalmic drug delivery --- dexamethasone --- PLGA-NPs --- nanomedicine --- gastrointestinal tract --- paclitaxel --- in vivo imaging --- controlled release --- risperidone --- microcapsules --- oleogels --- electron microscopy --- three-dimensional X-ray imaging --- nano-CT --- biodegradable polymers --- hydroxy-stearic acid --- PLGA nanocapsules --- magnetic resonance imaging --- photoluminescence --- magnetic targeting --- multimodal imaging --- theranostics --- silicon --- microsphere --- n/a --- Huntington's disease
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100 of the most creative designers to have emerged on the international scene over the past five years, chosen by 10 of the most respected figures in the field.
Graphic arts --- Commercial art --- Graphic artists --- Arts graphiques --- Art publicitaire --- Graphistes --- History --- Catalogs --- Catalogs. --- Directories --- Histoire --- Catalogues --- Répertoires --- Design graphique --- Dictionnaire --- Graphiste --- 766.039 --- Grafische vormgeving ; reclame ; 2000-2008 ; naslagwerken --- 178 aardige ontwerpers --- 75B --- 766.071 AAAA --- 766.39 --- A Practice for Everyday Life --- Antoine+Manuel --- Atrissi Tarek --- Bantjes Marian --- Barbara Says --- Big Active --- Bilak Peter --- Born Julia --- Brunner Laurenz --- Build --- Buxó Thomas --- Büro Uebele --- Catalogtree --- Chan Theseus --- Change Is Good --- Cheuk Deanne --- Chiappini Cristina --- Cho Peter --- Cobbenhagen & Hendriksen --- Cox Paul --- De Bondt Sara --- Duplessis Arem --- EYE --- Enlightenment --- FLAG Aubry/Broquard --- Farrell Stephen --- Flamingo Studio --- Friends With You --- Frostner Martin --- Gerritzen Mieke --- Good Design Company --- Groot Arjen --- Gubser Michelle --- Hardie George --- Hares Jonathan --- Hattori Kazunari --- Holder Will --- Homework --- Hugo Mario --- Itakura Keiko --- Ito Keiji --- Jarvis James --- Körner Union --- LUST --- Laboratoires CCCP --- Lehni Jürg --- Lehni-Trüb --- Lemi Ghariokwu --- MadeThought --- Marin Eduardo --- Martinez Meave Gabriel --- Maurer Luna --- Mayfried Thomas --- Meseguer Laura --- Mineur Etienne --- Naegele Isabel --- Namaiki --- Non-Format --- Nygren Henrik --- Office for Editorial Design --- Omnivore --- Opara Eddie --- Owens Mark --- Paper Rad --- Pesko Radim --- Post Typography --- Project Projects --- Punchman Michael --- Raad Iman --- Raeder Manuel --- Rementer Andy --- Rocha Claudio --- Sahar Michal --- Sandberg Martijn --- Siegel Claudia --- Sinister Dexter --- Sonderby Jennifer --- Spector --- Stavro Astrid --- Stegmann Frauke --- Stiletto --- Strange Attractors --- Studio 't Brandt Weer --- Studio Pip and Co. --- Sulki & Min --- Surface --- Tachibana Fumio --- Tinnes Andrea --- Toko --- Typographic Masonry --- Ukawa Naohiro --- United Visual Artists --- Yokoland --- eenentwintigste eeuw --- grafisch design --- grafische vormgeving --- mgmt. design --- typografie --- van Dam Vanessa --- van Dijk Bob --- van Halem Hansje --- 655.26 --- grafische designers --- Gebruiksgrafiek ; 2000 - 2050 --- grafische vormgeving, typografie --- graphic design --- Répertoires --- Studio Pip and Co --- Art, Graphic --- Arts, Graphic --- Graphic design (Graphic arts) --- Graphics --- Art --- Visual communication --- Advertising, Art in --- Advertising, Pictorial --- Advertising art --- Art, Commercial --- Art in advertising --- Commercial design --- Advertising --- Art and industry --- Posters --- Motion picture billboards --- Graphic arts - History - 20th century - Catalogs --- Graphic arts - History - 21st century - Catalogs --- Commercial art - History - 20th century - Catalogs --- Commercial art - History - 21st century - Catalogs
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