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THYROID HORMONES --- APOPTOSIS --- METALLOENDOPEPTIDASES

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Gene Deletion --- Myocardial Infarction --- Wound Healing --- Plasminogen --- Metalloendopeptidases --- genetics --- enzymology --- antagonists & inhibitors

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Polymorphism, Genetic. --- Asthma --- Metalloendopeptidases --- Polymorphism, Single Nucleotide. --- Airway Obstruction --- SNPs --- Single Nucleotide Polymorphism --- Nucleotide Polymorphism, Single --- Nucleotide Polymorphisms, Single --- Polymorphisms, Single Nucleotide --- Single Nucleotide Polymorphisms --- Genetic Polymorphisms --- Genetic Polymorphism --- Polymorphism (Genetics) --- Polymorphisms, Genetic --- genetics. --- etiology. --- Theses --- Polymorphisms (Genetics) --- Gene Polymorphism --- Gene Polymorphisms --- Polymorphism, Gene --- Polymorphisms, Gene --- Polymorphism, Genetic --- Polymorphism, Single Nucleotide --- genetics --- etiology

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The minimally invasive use of botulinum toxin (BoNT) in the lower urinary tract has revolutionized the treatment of debilitating bladder, urethra, and prostate conditions refractory to conventional therapy.  This is the first book focusing on the practical application of BoNT to the genitourinary tract.  An introductory section discusses the biology, pharmacology, and safety of BoNT in the lower urinary tract.  Applications of BoNT in the bladder and the prostate and pelvic floor are then covered in detail, with reviews of the latest clinical series and techniques of BoNT injection in both adults and children.  The book closes by considering non-genitourinary uses of BoNT and addressing issues of health economics as well as providing insights from experts from across the world.  This is a practical, hands-on book that also includes appendices containing easy to read instructions for patients undergoing bladder and prostate BoNT injections and specific nursing procedural issues.   The book is written in a concise, uniform, and clinically relevant style by two leading pioneers in the field, Drs. Michael Chancellor and Christopher Smith, who were the first to undertake comprehensive basic research into the mechanisms underlying the efficacy and potential uses of BoNT within the lower urinary tract.  Botulinum Toxin in Urology will be of interest to all urologists and urogynecologists who are considering the use of BoNT in their practice. .

Botulinum toxin -- Therapeutic use. --- Female Urogenital Diseases. --- Genitourinary organs -- Diseases -- Treatment. --- Pain -- Chemotherapy. --- Urology. --- Urology --- Metalloendopeptidases --- Female Urogenital Diseases --- Male Urogenital Diseases --- Bacterial Toxins --- Bacterial Proteins --- Diseases --- Metalloproteases --- Toxins, Biological --- Proteins --- Endopeptidases --- Female Urogenital Diseases and Pregnancy Complications --- Amino Acids, Peptides, and Proteins --- Biological Factors --- Peptide Hydrolases --- Hydrolases --- Chemicals and Drugs --- Enzymes --- Enzymes and Coenzymes --- Urologic Diseases --- Botulinum Toxins --- Medicine --- Health & Biological Sciences --- Urology & Nephrology --- Botulinum toxin. --- Botox (Trademark) --- Botulin --- Botulinismus toxin --- Botulinum neurotoxin --- Botulinus toxin --- Clostridium botulinum toxin --- Medicine. --- Gynecology. --- Neurology. --- Rehabilitation medicine. --- Medicine & Public Health. --- Rehabilitation Medicine. --- Genitourinary organs --- Bacterial toxins --- Neurotoxic agents --- Rehabilitation. --- Nervous system --- Neuropsychiatry --- Gynaecology --- Generative organs, Female --- Gynecology . --- Neurology . --- Medicine, Rehabilitation --- Rehabilitation medicine --- Rehabilitation --- Medicine, Physical --- Medical care. --- Health Care. --- Delivery of health care --- Delivery of medical care --- Health care --- Health care delivery --- Health services --- Healthcare --- Medical and health care industry --- Medical services --- Personal health services --- Public health

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Botulinum neurotoxins are the most toxic natural substances and represent a major threat to the population when intentionally released in bioterrorist attacks. On the other hand, during the past two decades botulinum neurotoxins have become established as indispensable drugs for the treatment of a variety of severe neurological disorders. The need for efficient countermeasures as well as the expansion into additional fields of therapeutic application, call for comprehensive information on the botulinum neurotoxin molecules and their mode of action. Our knowledge of this subject has made great strides in recent years, setting the stage for the development of new botulinum neurotoxin-based molecules and novel applications. This book reviews the current status of basic botulinum neurotoxin research. The first part describes the genetic variability of the toxin-producing bacteria, and sheds light on each step from toxin ingestion to the abrogation of synaptic signaling including the intestinal passage and absorption, nerve cell binding and entry, and intracellular substrate cleavage. The remaining chapters detail progress made in detection methods for botulinum neurotoxins, the development of botulinum neurotoxin inhibitors, and strategies to refine the neurotoxins for further medicinal applications by means of recombinant technologies.

Botulinum toxin -- Therapeutic use. --- Botulinum Toxins -- therapeutic use. --- Botulinum toxin --- Botulinum Toxins --- Biological Science Disciplines --- Peripheral Nervous System Agents --- Metalloendopeptidases --- Natural Science Disciplines --- Bacterial Proteins --- Physiological Effects of Drugs --- Bacterial Toxins --- Metalloproteases --- Pharmacologic Actions --- Toxins, Biological --- Proteins --- Disciplines and Occupations --- Endopeptidases --- Amino Acids, Peptides, and Proteins --- Biological Factors --- Peptide Hydrolases --- Chemical Actions and Uses --- Chemicals and Drugs --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Botulinum Toxins, Type A --- Pharmacology --- Neuromuscular Agents --- Health & Biological Sciences --- Human Anatomy & Physiology --- Medicine --- Animal Biochemistry --- Pharmacy, Therapeutics, & Pharmacology --- Neurology --- Therapeutic use --- Botulinum toxin. --- Neurotoxic agents. --- Neuropoisons --- Neurotoxicants --- Neurotoxins --- Botox (Trademark) --- Botulin --- Botulinismus toxin --- Botulinum neurotoxin --- Botulinus toxin --- Clostridium botulinum toxin --- Medicine. --- Neurosciences. --- Pharmacology. --- Biomedicine. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Poisons --- Bacterial toxins --- Neurotoxic agents --- Toxicology. --- Poisoning --- Toxicology --- Clostridium