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A large number of diseases affect salivary gland (SG) secretion through different mechanisms, leading to SG dysfunction and associated oral problems. The glands may suffer from viral, bacterial, and, albeit rarely, fungal infections, which may cause painful swelling or obstruction; they could also become the target of an autoimmune attack or may be affected by various benign and malignant tumors which consist of a heterogeneous group of lesions with complex clinical–pathological characteristics. The loss of normal SG function results in widespread deterioration of oral health. This book, entitled “Diseases of Salivary Glands”, provides an overview of recent advances in the field of SG disorders, focusing on the cellular and molecular mechanisms involved in the pathogenesis of SG diseases and on the most innovative investigation techniques that could help to preserve patients’ health, function, and quality of life.

Medicine --- salivary glands --- minor salivary glands --- salivary gland carcinoma --- mucoepidermoid carcinoma --- in situ carcinoma --- intra-cystic carcinoma --- chronic kidney disease --- salivary gland dysfunction --- salivary biomarkers --- oxidative stress --- nitrosative stress --- viral infection --- Epstein-Barr virus --- HTLV-1 --- salivary gland epithelial cell --- Hashimoto’s disease --- saliva --- Sjögren’s syndrome --- autoimmune disease --- physiopathology --- treatment --- diagnosis --- review --- primary Sjögren’s syndrome --- imaging --- salivary gland --- sialography --- salivary gland ultrasonography --- magnetic resonance imaging --- sialendoscopy --- salivary gland scintigraphy --- positron emission tomography --- NF-κB --- inflammation --- autoimmunity --- innate cells --- adaptive cells --- MR sialography --- dynamic --- sublingual gland ducts --- xerostomia --- SGEC --- immortalization --- acinar --- ductal --- spheroid --- n/a --- autoimmune diseases --- Sjögren syndrome --- B-cell lymphoma --- extranodal marginal zone lymphoma --- MALT lymphoma --- primary breast lymphoma --- radiation --- hyposalivation --- purinergic signaling --- bystander effect --- P2 receptors --- radioprotection --- head and neck cancer --- oral candidiasis --- Hashimoto's disease --- Sjögren's syndrome --- primary Sjögren's syndrome --- Sjögren syndrome

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Recent decades have seen remarkable advances in the treatment of upper gastrointestinal malignancies, i.e., adenocarcinoma and squamous cell carcinoma as well as gastrointestinal stromal and other rare tumors of the esophagus and stomach. While, historically, surgical resection has been the sole treatment for these tumors, multimodal therapies have meanwhile proven their efficacy. At present, pre- and postoperative chemotherapy and radiotherapy, targeted drug therapy, and stage-specific surgical approaches are all indispensable cornerstones of an individualized treatment for upper gastrointestinal malignancies. With such multimodal treatment, better outcomes comprising improved quality of life and prolonged survival have been achieved for patients. However, for many tumor entities and stages, the ideal combination and sequence of treatments is still being evaluated in clinical trials. Moreover, the value of novel approaches such as immunotherapy or robotic surgery remains a matter of research. In this Special Issue of Cancers, up-to-date original research, short communications, and comprehensive review articles on all modalities playing a role in the treatment of upper gastrointestinal malignancies have been published.

Public health & preventive medicine --- gastric cancer --- gastrectomy --- complications --- outcome --- survival --- lymph node ratio --- neoadjuvant chemotherapy --- conversion surgery --- cancer dormancy --- nuclear receptor NR2F1 --- clinical pathways --- gastric surgery --- oncological gastrectomy --- quality of care --- outcomes --- standardization --- adjuvant therapy --- gastrointestinal tract --- genetic diagnosis --- radiosensitivity --- mortality --- failure to rescue --- immunotherapy --- genetics --- esophageal cancer --- multidisciplinary --- gastric/gastroesophageal cancer --- perioperative chemotherapy --- overall survival --- relapse-free survival --- skeletal muscle index --- esophagectomy --- nutritional status --- sarcopenia --- esophageal anastomosis --- minimally invasive surgery --- induction chemotherapy --- chemo-radiotherapy --- neoadjuvant treatment --- esophageal squamous cell carcinoma --- multimodal treatment --- neoadjuvant chemoradiotherapy --- definitive chemoradiotherapy --- Lauren histotype --- gastrointestinal stromal tumor --- neuroendocrine tumor --- MALT lymphoma --- mucosal resection --- submucosal dissection --- GIST --- stomach --- neoadjuvant therapy --- imatinib --- organ preservation --- squamous cell esophageal cancer --- gastro-esophageal reflux disease --- Barrett’s esophagus --- early adenocarcinoma of esophagus --- endoscopic submucosal dissection --- endoscopic mucosal resection --- n/a --- Barrett's esophagus

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A large number of diseases affect salivary gland (SG) secretion through different mechanisms, leading to SG dysfunction and associated oral problems. The glands may suffer from viral, bacterial, and, albeit rarely, fungal infections, which may cause painful swelling or obstruction; they could also become the target of an autoimmune attack or may be affected by various benign and malignant tumors which consist of a heterogeneous group of lesions with complex clinical–pathological characteristics. The loss of normal SG function results in widespread deterioration of oral health. This book, entitled “Diseases of Salivary Glands”, provides an overview of recent advances in the field of SG disorders, focusing on the cellular and molecular mechanisms involved in the pathogenesis of SG diseases and on the most innovative investigation techniques that could help to preserve patients’ health, function, and quality of life.

salivary glands --- minor salivary glands --- salivary gland carcinoma --- mucoepidermoid carcinoma --- in situ carcinoma --- intra-cystic carcinoma --- chronic kidney disease --- salivary gland dysfunction --- salivary biomarkers --- oxidative stress --- nitrosative stress --- viral infection --- Epstein-Barr virus --- HTLV-1 --- salivary gland epithelial cell --- Hashimoto’s disease --- saliva --- Sjögren’s syndrome --- autoimmune disease --- physiopathology --- treatment --- diagnosis --- review --- primary Sjögren’s syndrome --- imaging --- salivary gland --- sialography --- salivary gland ultrasonography --- magnetic resonance imaging --- sialendoscopy --- salivary gland scintigraphy --- positron emission tomography --- NF-κB --- inflammation --- autoimmunity --- innate cells --- adaptive cells --- MR sialography --- dynamic --- sublingual gland ducts --- xerostomia --- SGEC --- immortalization --- acinar --- ductal --- spheroid --- n/a --- autoimmune diseases --- Sjögren syndrome --- B-cell lymphoma --- extranodal marginal zone lymphoma --- MALT lymphoma --- primary breast lymphoma --- radiation --- hyposalivation --- purinergic signaling --- bystander effect --- P2 receptors --- radioprotection --- head and neck cancer --- oral candidiasis --- Hashimoto's disease --- Sjögren's syndrome --- primary Sjögren's syndrome --- Sjögren syndrome

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Gastrointestinal tract disorders are a wide group of diseases involving both the gastrointestinal tube (esophagus, stomach, small and large intestine) and related organs (liver, pancreas, and gallbladder). These dysfunctions may differ by site, etiology, and severity, going from simple malfunctions to mere diseases. Because of their variety and heterogeneity, gastrointestinal disorders can affect many people and are widespread throughout the population. Therefore, scientific research in this area is facing a great challenge. Better knowledge of gastrointestinal disorders in terms of their pathophysiology, clinical features, and possible complications is necessary for the development of new diagnostic methods and therapeutic strategies. During the last several decades, some scientific developments have already been made, giving more opportunities to these patients. However, much remains to be discovered and to be done to help physicians in their everyday work and to give patients a better prognosis. The present Special Issue aims to highlight recent advances in gastrointestinal tract disorders, focusing on their diagnostic and therapeutic path, evolution, and complications.

Crohn’s disease --- ulcerative colitis --- biologics --- anemia --- gastroesophageal reflux --- cough --- asthma --- laryngo-pharyngeal reflux --- chest pain --- tooth erosions --- inflammatory bowel diseases --- sleep disorders --- sleep medicine --- PPI --- diverticulosis --- diverticulitis --- risk factors --- Marfan’s syndrome --- diverticula --- abdominal symptoms --- ultrasound --- infant --- food allergy --- fecal biomarkers --- tumor necrosis factor α --- eosinophil derived neurotoxin --- calprotectin --- Emorsan®Gel --- hemorrhoidal disease --- hemorrhoidectomy --- pain --- wound healing --- chronic idiopathic constipation --- constipation --- irritable bowel syndrome --- pathophysiology --- primary care --- medical students --- public health --- social media --- dietary habit --- pandemic --- dyspepsia --- diabetes --- gastroparesis --- inflammatory bowel disease --- SCORE --- carotid plaques --- cardiovascular risk --- dyssynergic defecation --- slow transit constipation --- motility --- colonic transit --- anorectal manometry --- gastrointestinal disorders --- endoscopic vacuum therapy --- etiology --- transmural defect --- upper gastrointestinal tract --- Helicobacter pylori --- eradication --- antibiotic resistance --- tailored --- empirical --- gastrointestinal bleeding --- new oral anticoagulants --- vitamin K antagonist --- rebleeding --- chronic gastritis --- peptic ulcer disease --- gastric cancer --- MALT-lymphoma --- therapy --- vaccines --- DA-9701 --- diabetic mouse model --- functional dyspepsia --- diabetic gastroparesis --- STZ --- gastrointestinal motility --- human leukocyte antigen --- celiac disease --- autoimmune hepatitis --- primary sclerosing cholangitis --- primary biliary cholangitis --- autoimmune pancreatitis --- IgG4-related sclerosing cholangitis --- IgG4-related hepatopathy --- n/a --- Crohn's disease --- Marfan's syndrome