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This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation; large-scale, high-speed MS sample profiling; new methods based on MALDI or MALDI-like sample preparations; and the advantages of MALDI MS analysis over ESI (electrospray ionization). This is an ideal book for graduate students and researchers in the field of bioanalytical sciences. This book also: • Showcases new techniques and applications in MALDI MS • Demonstrates how MALDI is preferable to ESI • Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and various application areas, such as cancer proteomics.
Biochemistry --- Chemistry --- Physical Sciences & Mathematics --- Mass spectrometry. --- Matrix-assisted laser desorption-ionization. --- Biomolecules --- Analysis. --- MALDI (Spectrum analysis) --- MALDI MS (Spectrum analysis) --- Mass spectra --- Mass spectrograph --- Mass spectroscopy --- Mass spectrum analysis --- Mass (Physics) --- Nuclear spectroscopy --- Spectrum analysis --- Mass spectrometry --- Biochemistry. --- Proteomics. --- Microbiology. --- Biotechnology. --- Protein Science. --- Mass Spectrometry. --- Applied Microbiology. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Chemical engineering --- Genetic engineering --- Microbial biology --- Microorganisms --- Molecular biology --- Proteins --- Composition --- Proteins . --- Proteids --- Polypeptides --- Proteomics
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This book presents the fundamentals and applications of Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-ToF-MS) technique. It highlights the basic principles, the history of invention as well as the mechanism of ionization and mass determination using this technique. It describes the fundamental principles and methods for MALDI spectra interpretation and determination of exact chemical structures from experimental data. This book guides the reader through the interpretation of MALDI data where complex macromolecular spectra are simplified in order to present the major principles behind data interpretation. In addition, each chapter describes how MALDI-ToF-MS analysis provides necessary understanding of the copolymer systems that have been designed for specialized biomedical applications.
Spectroscopy. --- Spectroscopy and Microscopy. --- Regenerative Medicine/Tissue Engineering. --- Pharmaceutical Sciences/Technology. --- Matrix-assisted laser desorption-ionization. --- MALDI (Spectrum analysis) --- MALDI MS (Spectrum analysis) --- Biomedical engineering. --- Mass spectrometry. --- Biotechnology. --- Pharmaceutical technology. --- Biomedical Engineering. --- Mass Spectrometry. --- Biomolecules --- Analysis. --- Mass spectra --- Mass spectrograph --- Mass spectroscopy --- Mass spectrum analysis --- Mass (Physics) --- Nuclear spectroscopy --- Spectrum analysis --- Mass spectrometry --- Biomedical Engineering and Bioengineering. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Chemical engineering --- Genetic engineering --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Microscopy. --- Regenerative medicine. --- Tissue engineering. --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Regeneration (Biology) --- Analysis, Microscopic --- Light microscopy --- Micrographic analysis --- Microscope and microscopy --- Microscopic analysis --- Optical microscopy --- Optics --- Analysis, Spectrum --- Spectra --- Spectrochemical analysis --- Spectrochemistry --- Spectrometry --- Spectroscopy --- Chemistry, Analytic --- Interferometry --- Radiation --- Wave-motion, Theory of --- Absorption spectra --- Light --- Spectroscope --- Qualitative --- Analytical chemistry
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