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Cardiovascular system --- Cardiovascular Diseases --- Precision Medicine. --- Diseases --- Genetics --- genetics. --- Appareil cardiovasculaire --- Médecine de précision --- Maladies --- Aspect génétique

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In the framework of the ATHENA project, where CHU Liège and Janssen are collaborating, my contribution and objectives demonstrated with this thesis were to explore and summarize through descriptive statistics, clinical data of patients with multiple myeloma to allow their characterization and improve treatments pathways in a personalized approach to medicine. The project took place in a federated environment and the analytics were developed using software such as R. Finally, the relevant insights of the analyses were presented in a visual way thanks to a dashboard (developed with the RShiny software) in a federated privacy-preserving platform. Dans le cadre du projet ATHENA, pour lequel collaborent le CHU de Liège et Janssen, ma contribution et mes objectifs avec ce mémoire étaient d'explorer et de résumer par des statistiques descriptives, les données cliniques de patients atteints de myélome multiple afin de permettre leur caractérisation et une amélioration de leur parcours de soins, dans une approche personnalisée de la médecine. Le projet s’est déroulé dans un environnement fédéré et les analyses ont été développées en utilisant des logiciels tels que R. Enfin, les résultats pertinents des analyses ont été présentés via des visualisations à travers un tableau de bord, plus communément appelé dashboard (développé avec le logiciel RShiny) dans une plateforme fédérée préservant la confidentialité des données des patients.

Federated Analytics --- Federated network --- Precision medicine --- Multiple Myeloma --- Myélome multiple --- Statistiques descriptives --- Analyses de survie --- Exploration de données --- Médecine de précision --- Sciences de la santé humaine > Oncologie --- Sciences du vivant > Anatomie (cytologie, histologie, embryologie...) & physiologie --- Sciences économiques & de gestion > Stratégie & innovation --- Ingénierie, informatique & technologie > Sciences informatiques --- Sciences du vivant > Biotechnologie

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Personalized medicine --- Drug development --- Pharmacogenetics --- Biochemical markers --- Precision Medicine. --- Biomarkers --- Drug Design. --- Clinical Laboratory Techniques --- Pharmacogenetics. --- Biochemical markers. --- Drug development. --- Personalized medicine. --- analysis. --- standards. --- Pharmacology --- Biochemical genetics --- Individualized medicine --- Medical care --- Development of drugs --- Drugs --- New drug development --- Pharmacy --- Biologic markers --- Biological markers --- Markers, Biochemical --- Biochemistry --- Indicators (Biology) --- Pharmacogenomics --- Pharmacogenomic Variants --- Drug Resistance --- Toxicology --- Precision Medicine --- Computer-Aided Drug Design --- Computerized Drug Design --- Drug Modeling --- Pharmaceutical Design --- Computer Aided Drug Design --- Computer-Aided Drug Designs --- Computerized Drug Designs --- Design, Pharmaceutical --- Drug Design, Computer-Aided --- Drug Design, Computerized --- Drug Designs --- Drug Modelings --- Pharmaceutical Designs --- P Health --- P-Health --- Personalized Medicine --- Theranostics --- Individualized Medicine --- Predictive Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- Medicine, Predictive --- Theranostic --- Patient-Specific Modeling --- Genetic aspects --- Development --- Precision medicine --- Precision medicine. --- Médecine de précision --- Médicaments --- Pharmacogénétique --- Marqueurs biologiques --- Développement