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This dissertation by Linda Helmfors investigates the dual role of lysozyme, a protein found in bodily fluids, as both a protective agent and a contributor to disease. Using a Drosophila melanogaster model, the research explores lysozyme's involvement in amyloidosis and its potential impact on Alzheimer's disease (AD). The study highlights how lysozyme mutations lead to protein misfolding and aggregation, contributing to systemic amyloidosis. Additionally, the research examines the interaction between lysozyme and amyloid β peptide, revealing lysozyme's protective role against AD-related neurotoxicity. The work also studies the role of serum amyloid P component (SAP) in amyloid diseases, suggesting it may aid in correct protein folding. This dissertation is aimed at scientists and researchers in the fields of biochemistry, molecular biology, and neurology, offering insights into protein misfolding diseases and potential therapeutic approaches.

Lysozyme. --- Amyloidosis.

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ADVANCES IN PROTEIN CHEMISTRY VOL 41

Proteins. --- Lysozyme. --- Mucopeptide glucohydrolase --- Muramidase --- Glycosidases --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

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Voedselallergieën zijn een groter wordend probleem in de wereld. Het treft twee tot drie procent van de wereldbevolking. Daarom is er nood aan kennis van allergenenoverdracht in de voedingsindustrie. ALLMOD (Allergeen modellering) is een Flanders' Food project waarin de allergeenrisico's in kaart gebracht worden in functie van proces-, product- en installatie-eigenschappen tijdens verdringing en na reiniging. In deze thesis wordt de kruiscontaminatie via productverdringing in gesloten processen voor emulsies en suspensies bestudeerd alsook adhesie van allergenen aan contactmaterialen.De productverdringing werd bestudeerd met behulp van het indicatorallergeen lysozyme. Eerst werd een batch allergeenbevattende emulsie/suspensie door de installatie gestuurd. Dit werd verdrongen door een batch allergeenvrij product. Kruiscontaminatie werd vergeleken tussen emulsie en suspensie met een gelijke viscositeit, emulsie met hoge en lage viscositeit en ook de complexiteit van de installatie werd gevarieerd.De concentratie lysozyme is het hoogst na 4 minuten verdringen bij hoogviskeuze emulsie (15,5 %), dan suspensie (7,3 %) en tenslotte bij laagviskeuze emulsie (1,5 %).Meer onderzoek is nodig om te kijken wanneer het product geen allergische reactie meer kan uitlokken, want dit is na 4 minuten nog steeds het geval. Ook om de invloed van de complexiteit van de installatie te bepalen moet nog verder onderzoek uitgevoerd worden.De adhesie van respectievelijk RVS, teflon, neopreen en HDPE met lysozyme en gliadine in emulsies en suspensies werd getest. Hieruit blijkt dat de adhesie het kleinst is bij HDPE en RVS en het grootst is bij teflon en neopreen.

Adhesie. --- Emulsie. --- Gluten. --- H350-linguïstiek. --- Indicatorallergenen. --- Kruiscontaminatie. --- Lysozyme. --- Productverdringing. --- S190-bedrijfsbeleid. --- S191-marktstudie. --- Suspensie. --- T430-levensmiddelentechnologie. --- Viscositeit.

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Lactoglobulins --- Egg white --- Enzymes --- Animal protein --- Texture --- chemical reactions --- Temperature. --- Temperature --- pH --- Ion exchange --- Structure moleculaire --- Hen egg white lysozyme --- Hewl --- Bovine beta-lactoglobulin

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Malaria remains an alarming emergency in developing countries. It is thus urgent to identify any parasite or host molecules that can serve as new affordable markers for early diagnosis of disease complications or as new targets for vector control. In this context, human and mosquito lysozymes are good candidate molecules, as their involvement in malaria has been recently reported by several independent groups. This book reviews the grounded knowledge on malaria etiology and physiopathology, as well as the current approaches for diagnosis, therapy, and vector control. In addition, the emerging evidence on the involvement of human and mosquito lysozymes in malaria from available experimental models and clinical studies is thoroughly discussed, as is the potential use of other antimicrobial peptides against malaria. Intriguingly, the contributors propose that old well-known molecules such as lysozymes might be used as new targets for cost-effective strategies to fight malaria. About the Editor Mauro Prato currently works as an Adjunct Professor of Biochemistry at the University of Torino, Italy. His research activity focuses on the involvement of proteolytic enzymes in malaria. His track-record includes 40 papers published by peer-reviewed journals, 1 book, 7 book chapters, 97 communications in well-established conferences, and 1 patent.

Biomedicine. --- Parasitology. --- Medical Microbiology. --- Immunology. --- Medicine. --- Microbiology. --- Medical parasitology. --- Médecine --- Immunologie --- Microbiologie --- Parasitologie médicale --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Lysozyme. --- Mucopeptide glucohydrolase --- Muramidase --- Medical microbiology. --- Glycosidases --- Immunobiology --- Life sciences --- Serology --- Microbial biology --- Microorganisms --- Human beings --- Human parasitology --- Medical sciences --- Parasitology --- Parasitic diseases --- Parasites