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This dissertation by Jannie Gregers focuses on childhood acute lymphoblastic leukaemia (ALL) with a primary emphasis on the drug methotrexate (MTX). It examines the impact of genetic polymorphisms in genes responsible for MTX influx (SLC19A1), efflux (ABCB1), and other MTX pathways (ATIC, MTHFR, SHMT) on the efficacy and toxicity of MTX treatment in children with ALL. The study includes in vitro experiments and clinical evaluations involving over 500 patients. Key findings indicate that specific genetic variations can influence treatment outcomes and side effects, highlighting the importance of personalized medicine in improving survival rates and reducing toxicity in pediatric ALL patients. The intended audience includes medical researchers, clinicians, and professionals in the field of oncology and pharmacology.

Lymphoblastic leukemia in children. --- Methotrexate.

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"This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches.  Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for  research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia"--Provided by publisher.

Lymphoblastic leukemia in children --- Lymphoblastic leukemia in children. --- Treatment. --- Medicine. --- Hematology. --- Oncology. --- Pediatrics. --- Medicine & Public Health. --- Leukemia in children --- Oncology  . --- Tumors --- Paediatrics --- Pediatric medicine --- Medicine --- Children --- Haematology --- Internal medicine --- Blood --- Diseases --- Health and hygiene

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When Eric Wendel was diagnosed with acute lymphoblastic leukemia in 1966, the survival rate was 10 percent. Today, it is 90 percent. Even as politicians call for a "Cancer Moonshot," this accomplishment remains a pinnacle in cancer research.The author’s daughter, then a medical student at Georgetown Medical School, told her father about this amazing success story. Tim Wendel soon discovered that many of the doctors at the forefront of this effort cared for his brother at Roswell Park in Buffalo, New York. Wendel went in search of this extraordinary group, interviewing Lucius Sinks, James Holland, Donald Pinkel, and others in the field. If there were a Mount Rushmore for cancer research, they would be on it.Despite being ostracized by their medical peers, these doctors developed modern-day chemotherapy practices and invented the blood centrifuge machine, helping thousands of children live longer lives. Part family memoir and part medical narrative, Cancer Crossings explores how the Wendel family found the courage to move ahead with their lives. They learned to sail on Lake Ontario, cruising across miles of open water together, even as the campaign against cancer changed their lives forever.

Lymphoblastic leukemia in children. --- Leukemia in children --- Cancer in children --- Pediatric hematology --- Patients --- Wendel, Tim. --- Wendel, Eric Gordon, --- Roswell Park Cancer Institute. --- Roswell Park Memorial Institute --- New York (State). --- R.P.C.I. --- RPCI --- Cancer, leukemia, Roswell Park, Buffalo, Memphis.