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The field of liver tumors in children, and in particular hepatoblastoma in infants and young children, has seen tremendous therapeutic advances over recent years. This has been achieved through a much better understanding of the biology of disease, improved diagnostic procedures, refined methods of pretreatment tumor staging, the implementation of highly efficient chemotherapy and surgery, detailed monitoring of toxicity, and careful follow-up strategies. International controlled trials have played a key role in these advances, and many leading figures in the trials are among the editors and authors of this book. Their principal goal in Hepatic Tumors in Children is to provide the reader with a complete update on this complex and rapidly evolving field. All aspects of an impressive success story are covered, disclosing how the outcome of a previously devastating disease has been so dramatically improved. This book will prove essential reading for all who are involved in the care of children with liver tumors.

Liver -- Cancer -- Treatment. --- Liver metastasis -- Treatment. --- Liver Neoplasms -- Therapy. --- Age Groups --- Digestive System Neoplasms --- Liver Diseases --- Neoplasms by Site --- Digestive System Diseases --- Persons --- Diseases --- Named Groups --- Neoplasms --- Liver Neoplasms --- Child --- Medicine --- Health & Biological Sciences --- Oncology --- Liver --- Tumors in children. --- Tumors --- Treatment. --- Pediatric oncology --- Medicine. --- Oncology. --- Pediatrics. --- Medicine & Public Health. --- Children --- Abdomen --- Biliary tract --- Oncology  . --- Paediatrics --- Pediatric medicine --- Health and hygiene

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Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential.    Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails.   Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge.    Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities.   By combining information on biological and clinical aspects of liver metastasis, this volume  will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.

Electronic books. -- local. --- Liver metastasis -- Treatment. --- Liver --- Digestive System Neoplasms --- Neoplastic Processes --- Liver Diseases --- Digestive System Diseases --- Neoplasms by Site --- Pathologic Processes --- Neoplasms --- Pathological Conditions, Signs and Symptoms --- Diseases --- Neoplasm Metastasis --- Liver Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Liver metastasis --- Treatment. --- Hepatic metastasis --- Medicine. --- Cancer research. --- Immunology. --- Radiology. --- Oncology. --- Surgical oncology. --- Biomedicine. --- Cancer Research. --- Surgical Oncology. --- Imaging / Radiology. --- Metastasis --- Oncology  . --- Radiology, Medical. --- Immunobiology --- Life sciences --- Serology --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Tumors --- Excision --- Treatment --- Radiological physics --- Physics --- Radiation --- Cancer research