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The field of liver tumors in children, and in particular hepatoblastoma in infants and young children, has seen tremendous therapeutic advances over recent years. This has been achieved through a much better understanding of the biology of disease, improved diagnostic procedures, refined methods of pretreatment tumor staging, the implementation of highly efficient chemotherapy and surgery, detailed monitoring of toxicity, and careful follow-up strategies. International controlled trials have played a key role in these advances, and many leading figures in the trials are among the editors and authors of this book. Their principal goal in Hepatic Tumors in Children is to provide the reader with a complete update on this complex and rapidly evolving field. All aspects of an impressive success story are covered, disclosing how the outcome of a previously devastating disease has been so dramatically improved. This book will prove essential reading for all who are involved in the care of children with liver tumors.

Liver -- Cancer -- Treatment. --- Liver metastasis -- Treatment. --- Liver Neoplasms -- Therapy. --- Age Groups --- Digestive System Neoplasms --- Liver Diseases --- Neoplasms by Site --- Digestive System Diseases --- Persons --- Diseases --- Named Groups --- Neoplasms --- Liver Neoplasms --- Child --- Medicine --- Health & Biological Sciences --- Oncology --- Liver --- Tumors in children. --- Tumors --- Treatment. --- Pediatric oncology --- Medicine. --- Oncology. --- Pediatrics. --- Medicine & Public Health. --- Children --- Abdomen --- Biliary tract --- Oncology  . --- Paediatrics --- Pediatric medicine --- Health and hygiene

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The management of colorectal liver metastases has evolved rapidly over the last decade with the introduction of newer and effective chemotherapies and a redefinition for cure. These range from the philosophical (including the greater awareness of treatment with curative intent), through the practical (more aggressive definition of respectability for cure and the use of more effective chemotherapies for both palliation and as adjuncts to surgery), to the futuristic use of biological strategies (including monoclonal antibodies and gene therapies) and lastly to the pragmatic but equally important issues of health economics (who is going to foot the bill for these increasingly expensive treatment strategies). Liver metastases addresses the contemporary multidisciplinary management of liver metastases. Throughout the text, experience from the paradigms of colorectal cancer metastases treatment strategies are used to point to new directions in the management of liver metastases from other cancers. This book overviews current understanding of the biology of liver metastases, and reviews current methods of detection and diagnosis. Chapters offer objective and systematic reviews of each of the current major treatment modalities: surgical resection; destructive therapies; chemotherapy (systemic and regional); whether there is a role for radiotherapy; biological therapies (including hormone treatment antibodies and gene therapy); and lastly the decision-making strategies that must be employed for successful multidisciplinary management. Featuring state-of-the-art reviews, key points, treatment algorithms and clear, concise illustrations this book provides the ultimate companion to anyone interested or working in the area of liver disease. This book will appeal to consultant and trainee surgeons in general surgery, hepatobiliary surgery, upper GI surgery, colorectal surgery; consultant and trainee medical and clinical oncologists with an interest in liver tumours; and consultant and trainee radiologists with an interest in liver disease.

Colorectal Neoplasms -- Pathology. --- Liver metastasis -- Treatment. --- Liver Neoplasms -- Secondary. --- Liver Neoplasms -- Therapy. --- Liver metastasis --- Colorectal Neoplasms --- Liver Neoplasms --- Pathology --- Intestinal Neoplasms --- Liver Diseases --- Rectal Diseases --- Digestive System Neoplasms --- Colonic Diseases --- Medicine --- Health Occupations --- Intestinal Diseases --- Gastrointestinal Neoplasms --- Digestive System Diseases --- Neoplasms by Site --- Diseases --- Neoplasms --- Gastrointestinal Diseases --- Disciplines and Occupations --- Oncology --- Health & Biological Sciences --- Treatment --- Liver --- Treatment. --- Cancer. --- Hepatocellular carcinoma --- Hepatic metastasis --- Medicine. --- Radiology. --- Oncology. --- Proctology. --- Surgery. --- Medicine & Public Health. --- Imaging / Radiology. --- Metastasis --- Cancer --- Oncology  . --- Endocrinology. --- Radiology, Medical. --- Internal medicine --- Hormones --- Tumors --- Surgery, Primitive --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Radiological physics --- Physics --- Radiation --- Gastroenterology