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Disease Models, Animal. --- Retroviridae --- Retroviridae Infections --- Retroviruses --- -C-type RNA viruses --- Leukemogenic viruses --- Leukoviruses --- Oncornaviruses --- Oncoviruses --- RNA tumor viruses --- Oncogenic viruses --- RNA viruses --- Animal Disease Model --- Animal Disease Models --- Disease Model, Animal --- Animals, Laboratory --- Models, Biological --- pathogenicity. --- veterinary. --- Congresses --- -pathogenicity. --- Retrovirus infections --- Disease Models, Animal --- Retroviral infections --- Virus diseases --- C-type RNA viruses --- veterinary --- pathogenicity --- Animals --- Diseases --- Veterinary virology

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This book presents a collection of health risk assessments for known and emerging hazards that span a continuum. Case studies for existing health risks include psychoactive drug usage in delivery truck drivers and using look-back risk assessment for accidental syringe re-use in healthcare settings. Case studies for emerging risks include precautionary actions to safeguard blood supplies; nanoparticle deposition in the lung; and the epistemic issues surrounding genetically modified organism risk assessments. The final section of the book deals with advancing health risk assessment analyses through a post-genomics lens and provides case studies on personalized genomics, new data analyses and improving in silico models for risk assessment. These case studies provide much insight into the ongoing evolution of health risk assessments.

Health risk assessment. --- Mouse leukemia viruses. --- Retroviruses. --- C-type RNA viruses --- Leukemogenic viruses --- Leukoviruses --- Oncornaviruses --- Oncoviruses --- Retroviridae --- RNA tumor viruses --- Oncogenic viruses --- RNA viruses --- Murine leukemia viruses --- Retroviruses --- Assessment, Health risk --- Health hazard appraisal --- Health hazard assessment --- Health risk appraisal --- HRA (Public health) --- Human risk assessment --- Medicine, Preventive --- Public health --- Risk assessment --- Environmental health

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Retroviridae Infections --- Retroviridae --- Retrovirus infections --- Retroviruses --- Infections à rétrovirus --- Rétrovirus --- Retrovirus infections. --- Retroviruses. --- Retroviridae. --- Genome, Viral. --- RNA, Viral --- Retroviridae Infections. --- genetics. --- physiology. --- 578.828 --- 578.24 --- Retroviridae. Retroviruses (RNA tumor viruses) --- Cell reactions to viral infections --- 578.24 Cell reactions to viral infections --- 578.828 Retroviridae. Retroviruses (RNA tumor viruses) --- Infections à rétrovirus --- Rétrovirus --- Retroviral infections --- Virus diseases --- C-type RNA viruses --- Leukemogenic viruses --- Leukoviruses --- Oncornaviruses --- Oncoviruses --- RNA tumor viruses --- Oncogenic viruses --- RNA viruses

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AIDS (Disease) --- HIV infections --- Retroviruses --- Acquired Immunodeficiency Syndrome. --- HIV Infections. --- Retroviridae. --- HIV infections. --- Retroviruses. --- C-type RNA viruses --- Leukemogenic viruses --- Leukoviruses --- Oncornaviruses --- Oncoviruses --- Retroviridae --- RNA tumor viruses --- HIV (Viruses) infections --- HTLV-III infections --- HTLV-III-LAV infections --- Human T-lymphotropic virus III infections --- Acquired immune deficiency syndrome --- Acquired immunodeficiency syndrome --- Acquired immunological deficiency syndrome --- Leukemogenic Viruses --- Oncovirinae --- Oncoviruses, Type C --- RNA Tumor Viruses --- Type C Oncoviruses --- C Oncovirus, Type --- C Oncoviruses, Type --- Leukemogenic Virus --- Leukovirus --- Oncornavirus --- Oncovirus --- Oncovirus, Type C --- RNA Tumor Virus --- Retrovirus --- Tumor Virus, RNA --- Tumor Viruses, RNA --- Type C Oncovirus --- Virus, Leukemogenic --- Virus, RNA Tumor --- Viruses, Leukemogenic --- Viruses, RNA Tumor --- HTLV-III Infections --- HTLV-III-LAV Infections --- T-Lymphotropic Virus Type III Infections, Human --- HIV Infection --- HTLV III Infections --- HTLV III LAV Infections --- HTLV-III Infection --- HTLV-III-LAV Infection --- Infection, HIV --- Infection, HTLV-III --- Infection, HTLV-III-LAV --- Infections, HIV --- Infections, HTLV-III --- Infections, HTLV-III-LAV --- T Lymphotropic Virus Type III Infections, Human --- Acquired Immune Deficiency Syndrome --- Acquired Immuno-Deficiency Syndrome --- AIDS --- Immunodeficiency Syndrome, Acquired --- Immunologic Deficiency Syndrome, Acquired --- Acquired Immuno Deficiency Syndrome --- Acquired Immuno-Deficiency Syndromes --- Acquired Immunodeficiency Syndromes --- Immuno-Deficiency Syndrome, Acquired --- Immuno-Deficiency Syndromes, Acquired --- Immunodeficiency Syndromes, Acquired --- Syndrome, Acquired Immuno-Deficiency --- Syndrome, Acquired Immunodeficiency --- Syndromes, Acquired Immuno-Deficiency --- Syndromes, Acquired Immunodeficiency --- Oncogenic viruses --- RNA viruses --- Lentivirus infections --- Sexually transmitted diseases --- Immunological deficiency syndromes --- Virus-induced immunosuppression --- HIV Coinfection --- Coinfection, HIV --- Coinfections, HIV --- HIV Coinfections --- CD4-Positive T-Lymphocytes --- HIV-1 --- AIDS Arteritis, Central Nervous System

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Retroviruses cause chronic infections and insertion mutations in their hosts, often leading to the appearance of tumors. Studies of retrovirus-induced tumors have led to our understanding of many crucial concepts in cell and cancer biology, including the discoveries of reverse transcriptase, viral oncogenes, cellular proto-oncogenes and signal transduction pathways. This monograph provides an intriguing set of chapters on the many facets of retroviral involvement in cancers arising in a variety of organisms from fish to humans. Each chapter is written by experts in the field and relates recent work to previous experimental data. Retroviruses use many different mechanisms to induce cancers, ranging from activation of microRNAs, inactivation of tumor suppressor genes, activation or modifications of proto-oncogenes, as well as expression of viral proteins that manipulate cell signaling and the immune system. In recent years, retroviruses have been used as tools, not only for the characterization of cellular pathways, but also as vectors to deliver therapeutic or engineered genes. This knowledge is all the more startling due to the revelation that nearly 10% of the human genome consists of endogenous retroviruses, including many that are transcriptionally active. The emergence of new endogenous retroviruses causing lethal leukemias in koalas and, potentially, prostate cancer in humans ensures that the unique interactions of these viruses with their hosts will continue to fascinate and illuminate us.

Carcinogenesis. --- Foreign workers --Germany (West). --- German language --Social aspects. --- German language --Syntax --Study and teaching --Foreign speakers. --- Grammar, Comparative and general. --- Language and languages --Variation. --- Retrovirus infections. --- Viral carcinogenesis. --- Retroviruses --- Oncogenic viruses --- Viral carcinogenesis --- RNA Viruses --- Vertebrate Viruses --- Genes --- Diseases --- Viruses --- Genome Components --- Genome --- Organisms --- Genetic Structures --- Genetic Phenomena --- Phenomena and Processes --- Retroviridae --- Oncogenic Viruses --- Genes, Neoplasm --- Neoplasms --- Biology --- Medicine --- Health & Biological Sciences --- Microbiology & Immunology --- Oncology --- Language and languages --- Grammar, Comparative and general --- German language --- Foreign workers --- Languages & Literatures --- Philology & Linguistics --- Variation --- Study and teaching --- Syntax --- Foreign speakers --- Social aspects --- Retroviruses. --- Oncogenic viruses. --- C-type RNA viruses --- Leukemogenic viruses --- Leukoviruses --- Oncornaviruses --- Oncoviruses --- RNA tumor viruses --- Cancer-causing viruses --- Cancer viruses --- Oncoviruses (Oncogenic viruses) --- Tumor viruses --- Tumorigenic viruses --- Medicine. --- Cancer research. --- Medical microbiology. --- Virology. --- Biomedicine. --- Cancer Research. --- Medical Microbiology. --- RNA viruses --- Microbial carcinogenesis --- Oncology. --- Medical virology. --- Microbiology. --- Medical microbiology --- Virology --- Virus diseases --- Tumors --- Microbial biology --- Microorganisms --- Microbiology --- Cancer research