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This book, written by a team of leading experts, provides a comprehensive overview of acute myeloid leukemia (AML), the most frequent acute leukemia in adults. The opening chapters present current knowledge of epidemiology, etiologic factors, and the pathogenesis and molecular development of AML. Detailed guidance is offered on laboratory and clinical diagnostic workup and disease classification, and the patient- and disease-related factors that determine prognosis and treatment allocation are identified. On the basis of these general considerations, initial treatments in patients considered fit for intensive treatment and in older and co-morbid patients are reviewed, and the available relapse treatment strategies, explained. For all clinical scenarios, the most recent data on the optimal use of newly approved agents in different AML subgroups are presented. Separate chapters address the treatment of acute promyelocytic leukemia, current practice of allogeneic stem cell transplantation, and special clinical situations. Finally, promising approaches in drug development, current standards and challenges in assessment of measurable residual disease, immune approaches, and ideas for innovative trial designs are considered.
Hematology. --- Haematology --- Internal medicine --- Blood --- Diseases --- Acute myeloid leukemia. --- Acute myelogenous leukemia --- Acute myeloid granulocytic leukemia --- Acute myelocytic leukemia --- AML (Disease) --- Acute leukemia --- Myeloid leukemia --- Leukemia, Myeloid, Acute. --- ANLL --- Acute Myelogenous Leukemia --- Acute Myeloid Leukemia --- Acute Myeloid Leukemia with Maturation --- Acute Myeloid Leukemia without Maturation --- Leukemia, Acute Myelogenous --- Leukemia, Acute Myeloid --- Leukemia, Myeloblastic, Acute --- Leukemia, Myelocytic, Acute --- Leukemia, Myeloid, Acute, M1 --- Leukemia, Myeloid, Acute, M2 --- Leukemia, Nonlymphoblastic, Acute --- Myeloblastic Leukemia, Acute --- Myelocytic Leukemia, Acute --- Myelogenous Leukemia, Acute --- Myeloid Leukemia, Acute, M1 --- Myeloid Leukemia, Acute, M2 --- Nonlymphoblastic Leukemia, Acute --- Leukemia, Myelogenous, Acute --- Leukemia, Nonlymphocytic, Acute --- Myeloid Leukemia, Acute --- Nonlymphocytic Leukemia, Acute --- Acute Myeloblastic Leukemia --- Acute Myeloblastic Leukemias --- Acute Myelocytic Leukemia --- Acute Myelocytic Leukemias --- Acute Myelogenous Leukemias --- Acute Myeloid Leukemias --- Acute Nonlymphoblastic Leukemia --- Acute Nonlymphoblastic Leukemias --- Acute Nonlymphocytic Leukemia --- Acute Nonlymphocytic Leukemias --- Leukemia, Acute Myeloblastic --- Leukemia, Acute Myelocytic --- Leukemia, Acute Nonlymphoblastic --- Leukemia, Acute Nonlymphocytic --- Leukemias, Acute Myeloblastic --- Leukemias, Acute Myelocytic --- Leukemias, Acute Myelogenous --- Leukemias, Acute Myeloid --- Leukemias, Acute Nonlymphoblastic --- Leukemias, Acute Nonlymphocytic --- Myeloblastic Leukemias, Acute --- Myelocytic Leukemias, Acute --- Myelogenous Leukemias, Acute --- Myeloid Leukemias, Acute --- Nonlymphoblastic Leukemias, Acute --- Nonlymphocytic Leukemias, Acute --- Leucèmia mieloide --- Leucèmia granulocítica --- Leucèmia mielocítica --- Leucèmia mielògena --- Leucèmia --- Trastorns mieloproliferatius
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This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.
Leucèmia --- Medul·la òssia --- Quimioteràpia del càncer --- Ciències de la salut --- Biomedicina --- Ciències biomèdiques --- Ciències mèdiques --- Ciències de la vida --- Fisiologia humana --- Microbiologia mèdica --- Neurociències --- Quimioteràpia anticancerosa --- Quimioteràpia antineoplàsica --- Quimioteràpia --- Medicaments antineoplàstics --- Sistema immunitari --- Trastorns mieloproliferatius --- Anèmia --- Càncer --- Leucèmia aguda --- Leucèmia en els infants --- Leucèmia mieloide --- Acute leukemia. --- Leukemia --- Leukemia. --- Leukemia, Myeloid, Acute. --- Myelodysplastic Syndromes. --- Bone Marrow Neoplasms. --- Neoplasms, Bone Marrow --- Bone Marrow Neoplasm --- Neoplasm, Bone Marrow --- Hematopoetic Myelodysplasia --- Dysmyelopoietic Syndromes --- Dysmyelopoietic Syndrome --- Hematopoetic Myelodysplasias --- Myelodysplasia, Hematopoetic --- Myelodysplasias, Hematopoetic --- Myelodysplastic Syndrome --- Syndrome, Dysmyelopoietic --- Syndrome, Myelodysplastic --- Syndromes, Dysmyelopoietic --- Syndromes, Myelodysplastic --- ANLL --- Acute Myelogenous Leukemia --- Acute Myeloid Leukemia --- Acute Myeloid Leukemia with Maturation --- Acute Myeloid Leukemia without Maturation --- Leukemia, Acute Myelogenous --- Leukemia, Acute Myeloid --- Leukemia, Myeloblastic, Acute --- Leukemia, Myelocytic, Acute --- Leukemia, Myeloid, Acute, M1 --- Leukemia, Myeloid, Acute, M2 --- Leukemia, Nonlymphoblastic, Acute --- Myeloblastic Leukemia, Acute --- Myelocytic Leukemia, Acute --- Myelogenous Leukemia, Acute --- Myeloid Leukemia, Acute, M1 --- Myeloid Leukemia, Acute, M2 --- Nonlymphoblastic Leukemia, Acute --- Leukemia, Myelogenous, Acute --- Leukemia, Nonlymphocytic, Acute --- Myeloid Leukemia, Acute --- Nonlymphocytic Leukemia, Acute --- Acute Myeloblastic Leukemia --- Acute Myeloblastic Leukemias --- Acute Myelocytic Leukemia --- Acute Myelocytic Leukemias --- Acute Myelogenous Leukemias --- Acute Myeloid Leukemias --- Acute Nonlymphoblastic Leukemia --- Acute Nonlymphoblastic Leukemias --- Acute Nonlymphocytic Leukemia --- Acute Nonlymphocytic Leukemias --- Leukemia, Acute Myeloblastic --- Leukemia, Acute Myelocytic --- Leukemia, Acute Nonlymphoblastic --- Leukemia, Acute Nonlymphocytic --- Leukemias, Acute Myeloblastic --- Leukemias, Acute Myelocytic --- Leukemias, Acute Myelogenous --- Leukemias, Acute Myeloid --- Leukemias, Acute Nonlymphoblastic --- Leukemias, Acute Nonlymphocytic --- Myeloblastic Leukemias, Acute --- Myelocytic Leukemias, Acute --- Myelogenous Leukemias, Acute --- Myeloid Leukemias, Acute --- Nonlymphoblastic Leukemias, Acute --- Nonlymphocytic Leukemias, Acute --- Leucocythaemia --- Leucocythemia --- Leucocythaemias --- Leucocythemias --- Leukemias --- Myeloproliferative Disorders --- Hematologic Neoplasms --- Terapèutica --- Teràpia --- Tractament (Medicina) --- Tractament de les malalties --- Medicina clínica --- Al·lopatia (Terapèutica) --- Antipirètics --- Cateterisme --- Dietoteràpia --- Fisioteràpia --- Fórmules magistrals --- Hormonoteràpia --- Immunoteràpia --- Injeccions intraarticulars --- Intubació --- Ioga --- Logopèdia --- Medicina alternativa --- Nutrició --- Radiologia intervencionista --- Terapèutica dental --- Terapèutica fisiològica --- Teràpia genètica --- Teràpia intravenosa --- Teràpia respiratòria --- Terapèutica veterinària --- Tractament pal·liatiu --- Ús terapèutic --- Leucèmia granulocítica --- Leucèmia mielocítica --- Leucèmia mielògena --- Hematology. --- Oncology. --- Medicine --- Biology --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Health Workforce --- Tumors --- Haematology --- Internal medicine --- Blood --- Diseases
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Cancer --- Kanker --- Maladies --- Ziekten --- Leukemia. --- 616.1 --- Leukemie (bloedkanker) --- Leucocythaemia --- Leucocythemia --- Leucocythaemias --- Leucocythemias --- Leukemias --- Myeloproliferative Disorders --- Hematologic Neoplasms --- Leukemia
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Leukemia --- Leukemia. --- Leucaemia --- Leucemia --- Leucocythaemia --- Leucocythemia --- Leucosis --- Leukaemia --- Leukosis --- Leucocythaemias --- Leucocythemias --- Leukemias --- Anemia --- Cancer --- Leucocytosis --- Preleukemia --- Myeloproliferative Disorders --- Hematologic Neoplasms
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Hematology --- Hematología --- Haematology --- Internal medicine --- Blood --- Diseases --- lymphoid leukemias --- immunogenetics --- non neoplastic blood disorders --- transplantation --- target therapy --- immunobiology
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Provides a visual presentation of myeloproliferative neoplasms and myeloid leukaemia, meeting the needs of haematologists and clinical chemists. Covers clinical presentation, haematological and pathological features, immunophenotyping and cytogenetic and genetic abnormalities. Heavily illustrated throughout with colour photographs and diagrams, this resource fills a gap in the literature and is an essential reference for all haematologists.
Bone marrow -- Diseases -- Diagnosis. --- Bone marrow -- Diseases. --- Bone Marrow -- Pathology. --- Bone Marrow Diseases -- Diagnosis. --- Myeloid leukemia -- Atlases. --- Myeloproliferative disorders -- Atlases. --- Tumors -- Atlases. --- Leukemia --- Bone Marrow Diseases --- Hematologic Diseases --- Neoplasms by Histologic Type --- Myeloproliferative Disorders --- Leukemia, Myeloid --- Neoplasms --- Hemic and Lymphatic Diseases --- Diseases --- Medicine --- Health & Biological Sciences --- Hematological Diseases --- Blood Diseases --- Blood Disease --- Disease, Blood --- Disease, Hematologic --- Disease, Hematological --- Diseases, Blood --- Diseases, Hematologic --- Diseases, Hematological --- Hematologic Disease --- Hematological Disease --- Bone Marrow Disease --- Disease, Bone Marrow --- Diseases, Bone Marrow --- Marrow Disease, Bone --- Marrow Diseases, Bone --- Leucocythaemia --- Leucocythemia --- Leucocythaemias --- Leucocythemias --- Leukemias --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Leukemia, Monocytic, Chronic --- Monocytic Leukemia, Chronic --- Granulocytic Leukemia --- Leukemia, Granulocytic --- Leukemia, Myelocytic --- Leukemia, Myelogenous --- Myelocytic Leukemia --- Myelogenous Leukemia --- Myeloid Leukemia --- Chronic Monocytic Leukemia --- Chronic Monocytic Leukemias --- Granulocytic Leukemias --- Leukemia, Chronic Monocytic --- Leukemias, Chronic Monocytic --- Leukemias, Granulocytic --- Leukemias, Myelocytic --- Leukemias, Myelogenous --- Leukemias, Myeloid --- Monocytic Leukemias, Chronic --- Myelocytic Leukemias --- Myelogenous Leukemias --- Myeloid Leukemias --- Disorder, Myeloproliferative --- Disorders, Myeloproliferative --- Myeloproliferative Disorder --- Histological Type of Neoplasm --- Histological Types of Neoplasms --- Neoplasms by Histological Type --- Neoplasm Histological Type --- Neoplasm Histological Types --- Neoplasms Histological Type --- Neoplasms Histological Types --- Hematology --- Hematologic Neoplasms --- Malignant Neoplasms --- Malignant Neoplasm --- Neoplasm, Malignant --- Neoplasms, Malignant --- Medical Oncology --- Blood and Lymphatic System Disorders
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Leukemia --- Leukemia. --- Leucaemia --- Leucemia --- Leucocythaemia --- Leucocythemia --- Leucosis --- Leukaemia --- Leukosis --- Leucocythaemias --- Leucocythemias --- Leukemias --- Anemia --- Cancer --- Leucocytosis --- Preleukemia --- Myeloproliferative Disorders --- Hematologic Neoplasms --- Hematologic Diseases
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Leukemia Research is an international journal which brings comprehensive and current information to all health care professionals involved in basic and (or) applied clinical research in leukemias, lymphomas, multiple myeloma and other hematologic malignancies. The editors encourage the submission of articles relevant to normal and leukemic hemopoiesis, biochemistry, cell biology, immunology and molecular biology as well as epidemiologic and clinical studies.
Pathological haematology --- Leukemia --- Leucémie --- Periodicals --- Research --- Périodiques --- Recherche --- Leukemia. --- Leucocythaemia --- Leucocythemia --- Leucocythaemias --- Leucocythemias --- Leukemias --- Myeloproliferative Disorders --- Hematologic Neoplasms --- Chemistry --- Health Sciences --- Biochemistry --- Clinical Medicine --- Oncology --- Leucaemia --- Leucemia --- Leucosis --- Leukaemia --- Leukosis --- Anemia --- Cancer --- Leucocytosis --- Preleukemia --- leukemie --- Journal --- Leucémie. --- Man --- Blood
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Leukemia --- Leukemia. --- Treatment --- therapy. --- Treatment. --- Leucaemia --- Leucemia --- Leucocythaemia --- Leucocythemia --- Leucosis --- Leukaemia --- Leukosis --- Leucocythaemias --- Leucocythemias --- Leukemias --- Anemia --- Cancer --- Leucocytosis --- Preleukemia --- Myeloproliferative Disorders --- Hematologic Neoplasms --- therapy --- leukemie --- Hematologic Diseases --- Leucèmia. --- Anèmia --- Càncer --- Leucèmia aguda --- Leucèmia en els infants --- Leucèmia mieloide
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Leukemia. --- Leukemia, Lymphoid. --- Leucaemia --- Leucemia --- Leucocythaemia --- Leucocythemia --- Leucosis --- Leukaemia --- Leukosis --- Anemia --- Cancer --- Leucocytosis --- Preleukemia --- Leukemia, Lymphocytic --- Lymphocytic Leukemia --- Lymphoid Leukemia --- Leukemias, Lymphocytic --- Leukemias, Lymphoid --- Lymphocytic Leukemias --- Lymphoid Leukemias --- Lymphatic Diseases --- Lymphoblastic leukemia. --- Precursor Cell Lymphoblastic Leukemia-Lymphoma --- ALL, Childhood --- Acute Lymphoid Leukemia --- Leukemia, Acute Lymphoblastic --- Leukemia, Lymphoblastic, Acute --- Leukemia, Lymphoblastic, Acute, L1 --- Leukemia, Lymphoblastic, Acute, L2 --- Leukemia, Lymphoblastic, Acute, Philadelphia-Positive --- Leukemia, Lymphocytic, Acute --- Leukemia, Lymphocytic, Acute, L1 --- Leukemia, Lymphocytic, Acute, L2 --- Lymphoblastic Leukemia, Acute --- Lymphoblastic Leukemia, Acute, Adult --- Lymphoblastic Leukemia, Acute, Childhood --- Lymphoblastic Leukemia, Acute, L1 --- Lymphoblastic Leukemia, Acute, L2 --- Lymphocytic Leukemia, L1 --- Lymphocytic Leukemia, L2 --- Leukemia, Lymphoblastic --- Leukemia, Lymphoid, Acute --- Lymphoblastic Leukemia --- Lymphoblastic Lymphoma --- Lymphocytic Leukemia, Acute --- Lymphoma, Lymphoblastic --- Acute Lymphoblastic Leukemia --- Acute Lymphocytic Leukemia --- Childhood ALL --- L1 Lymphocytic Leukemia --- L2 Lymphocytic Leukemia --- Leukemia, Acute Lymphocytic --- Leukemia, Acute Lymphoid --- Leukemia, L1 Lymphocytic --- Leukemia, L2 Lymphocytic --- Lymphoid Leukemia, Acute --- Precursor Cell Lymphoblastic Leukemia Lymphoma --- Acute lymphocytic leukemia --- Lymphocytic leukemia
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