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This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the impact of availability of generic imatinib. .

Oncology  . --- Hematology. --- Oncology. --- Haematology --- Internal medicine --- Blood --- Tumors --- Diseases --- Leukemia --- diagnosis. --- Chronic myeloid leukemia. --- Chronic granulocytic leukemia --- Chronic myelocytic leukemia --- Chronic myelogenous leukemia --- CML (Disease) --- Chronic leukemia --- Myeloid leukemia --- Leucèmia mieloide --- Leucèmia granulocítica --- Leucèmia mielocítica --- Leucèmia mielògena --- Leucèmia --- Trastorns mieloproliferatius

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This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.

Leucèmia --- Medul·la òssia --- Quimioteràpia del càncer --- Ciències de la salut --- Biomedicina --- Ciències biomèdiques --- Ciències mèdiques --- Ciències de la vida --- Fisiologia humana --- Microbiologia mèdica --- Neurociències --- Quimioteràpia anticancerosa --- Quimioteràpia antineoplàsica --- Quimioteràpia --- Medicaments antineoplàstics --- Sistema immunitari --- Trastorns mieloproliferatius --- Anèmia --- Càncer --- Leucèmia aguda --- Leucèmia en els infants --- Leucèmia mieloide --- Acute leukemia. --- Leukemia --- Leukemia. --- Leukemia, Myeloid, Acute. --- Myelodysplastic Syndromes. --- Bone Marrow Neoplasms. --- Neoplasms, Bone Marrow --- Bone Marrow Neoplasm --- Neoplasm, Bone Marrow --- Hematopoetic Myelodysplasia --- Dysmyelopoietic Syndromes --- Dysmyelopoietic Syndrome --- Hematopoetic Myelodysplasias --- Myelodysplasia, Hematopoetic --- Myelodysplasias, Hematopoetic --- Myelodysplastic Syndrome --- Syndrome, Dysmyelopoietic --- Syndrome, Myelodysplastic --- Syndromes, Dysmyelopoietic --- Syndromes, Myelodysplastic --- ANLL --- Acute Myelogenous Leukemia --- Acute Myeloid Leukemia --- Acute Myeloid Leukemia with Maturation --- Acute Myeloid Leukemia without Maturation --- Leukemia, Acute Myelogenous --- Leukemia, Acute Myeloid --- Leukemia, Myeloblastic, Acute --- Leukemia, Myelocytic, Acute --- Leukemia, Myeloid, Acute, M1 --- Leukemia, Myeloid, Acute, M2 --- Leukemia, Nonlymphoblastic, Acute --- Myeloblastic Leukemia, Acute --- Myelocytic Leukemia, Acute --- Myelogenous Leukemia, Acute --- Myeloid Leukemia, Acute, M1 --- Myeloid Leukemia, Acute, M2 --- Nonlymphoblastic Leukemia, Acute --- Leukemia, Myelogenous, Acute --- Leukemia, Nonlymphocytic, Acute --- Myeloid Leukemia, Acute --- Nonlymphocytic Leukemia, Acute --- Acute Myeloblastic Leukemia --- Acute Myeloblastic Leukemias --- Acute Myelocytic Leukemia --- Acute Myelocytic Leukemias --- Acute Myelogenous Leukemias --- Acute Myeloid Leukemias --- Acute Nonlymphoblastic Leukemia --- Acute Nonlymphoblastic Leukemias --- Acute Nonlymphocytic Leukemia --- Acute Nonlymphocytic Leukemias --- Leukemia, Acute Myeloblastic --- Leukemia, Acute Myelocytic --- Leukemia, Acute Nonlymphoblastic --- Leukemia, Acute Nonlymphocytic --- Leukemias, Acute Myeloblastic --- Leukemias, Acute Myelocytic --- Leukemias, Acute Myelogenous --- Leukemias, Acute Myeloid --- Leukemias, Acute Nonlymphoblastic --- Leukemias, Acute Nonlymphocytic --- Myeloblastic Leukemias, Acute --- Myelocytic Leukemias, Acute --- Myelogenous Leukemias, Acute --- Myeloid Leukemias, Acute --- Nonlymphoblastic Leukemias, Acute --- Nonlymphocytic Leukemias, Acute --- Leucocythaemia --- Leucocythemia --- Leucocythaemias --- Leucocythemias --- Leukemias --- Myeloproliferative Disorders --- Hematologic Neoplasms --- Terapèutica --- Teràpia --- Tractament (Medicina) --- Tractament de les malalties --- Medicina clínica --- Al·lopatia (Terapèutica) --- Antipirètics --- Cateterisme --- Dietoteràpia --- Fisioteràpia --- Fórmules magistrals --- Hormonoteràpia --- Immunoteràpia --- Injeccions intraarticulars --- Intubació --- Ioga --- Logopèdia --- Medicina alternativa --- Nutrició --- Radiologia intervencionista --- Terapèutica dental --- Terapèutica fisiològica --- Teràpia genètica --- Teràpia intravenosa --- Teràpia respiratòria --- Terapèutica veterinària --- Tractament pal·liatiu --- Ús terapèutic --- Leucèmia granulocítica --- Leucèmia mielocítica --- Leucèmia mielògena --- Hematology. --- Oncology. --- Medicine --- Biology --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Health Workforce --- Tumors --- Haematology --- Internal medicine --- Blood --- Diseases