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Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.

Insulin-like growth factor-binding proteins. --- Laron dwarfism. --- Somatomedin. --- Somatotropin. --- Laron dwarfism --- Laron dwarfism $x Treatment --- Phenotype --- Somatomedins --- Dwarfism --- Investigative Techniques --- Murinae --- Muridae --- Bone Diseases, Developmental --- Blood Proteins --- Intercellular Signaling Peptides and Proteins --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genetic Diseases, Inborn --- Endocrine System Diseases --- Laron Syndrome --- Models, Animal --- Mice --- Insulin-Like Growth Factor I --- Rodentia --- Bone Diseases --- Biological Factors --- Diseases --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Proteins --- Peptides --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Mammals --- Musculoskeletal Diseases --- Vertebrates --- Chordata --- Animals --- Eukaryota --- Organisms --- Medicine --- Health & Biological Sciences --- Pediatrics --- Dwarfism, Pituitary. --- Growth hormone deficiency --- Hypophyseal dwarfism --- Levi-Lorian dwarfism --- Paltauf's dwarfism --- Pituitary dwarfism --- Somatotropin deficiency --- Laron syndrome --- Laron-type dwarfism --- Somatomedin deficiency --- Medicine. --- Human genetics. --- Human physiology. --- Molecular biology. --- Internal medicine. --- Endocrinology. --- Pediatrics. --- Medicine & Public Health. --- Internal Medicine. --- Human Genetics. --- Molecular Medicine. --- Human Physiology. --- Child development deviations --- Pediatric endocrinology --- Pituitary gland --- Dwarfism, Pituitary --- Internal medicine --- Hormones --- Paediatrics --- Pediatric medicine --- Children --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Genetics --- Heredity, Human --- Physical anthropology --- Medicine, Internal --- Health and hygiene --- Health Workforce --- Endocrinology . --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology