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Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
human liver microsomes --- alcohol addiction --- UGT --- ultra-high-pressure liquid chromatography --- adalimumab --- procainamide --- LC-MS/MS --- DA-9805 --- paeonol --- LC-QTOF-MS/MS --- YRA-1909 --- chlorogenic acid --- immunoprecipitation --- Eurycoma longifolia --- CYP --- caffeic acid --- rat --- pharmaceutical excipient --- Korean red ginseng extract --- Stauntonia hexaphylla leaf extract --- bioanalysis --- HPLC-MS/MS --- B6 --- eurycomanone --- bioavailability --- drying technology --- GB3 --- diclofenac --- 129-Glatm1Kul/J --- aglycone --- caffeic acid O-glucuronides --- organic anion transporting polypeptide --- protein precipitation --- metabolic stability --- Fabry disease --- biopharmaceuticals --- imperatorin --- neochlorogenic acid --- gastric ulcer --- saikosaponin a --- hair --- anthraquinone --- acetyl tributyl citrate --- pharmacokinetics --- brain distribution --- mematine --- ethyl glucuronide --- pharmacokinetic --- loxoprofen --- liquid chromatography-quadrupole TOF MS --- glucuronidation --- esomeprazole --- metformin --- cytochrome P450 --- glycoside --- AUDIT score --- protein stability --- efficacy --- LC-HR/MS --- cryptochlorogenic acid --- aceclofenac --- drug interaction --- liquid chromatography-tandem mass spectrometry --- Osthenol --- plasma --- N-acetylprocainamide --- diabetes --- Drugs --- Metabolism. --- Drug metabolism --- Pharmacokinetics
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“Antioxidant Activity of Polyphenolic Plant Extracts” is a collection of scientific articles regarding polyphenols, that is, substances occurring naturally in plants and exhibiting many beneficial effects on human health. Among polyphenols’ interesting biological properties, their antioxidant activity is considered the most important. This book brings together experts from different research fields on topics related to polyphenols, such as their isolation and purification, assessment of their antioxidant activity, prevention from oxidative stress-induced diseases and use as food additives. The polyphenols used in the present studies are derived from a great variety of plants, ranging from well-known species to rare ones that are only found in specific regions. Moreover, some of the studies provide evidence that polyphenols may be used for the prevention and treatment of common diseases such as diabetes mellitus, Alzheimers’ disease, cardiovascular and intestinal diseases. Importantly, in several of the studies “green extraction methods” for the isolation of polyphenols were developed using modern technologies, where few or no organic solvents were used, in order to minimize environmental and health impacts.
Research & information: general --- Biology, life sciences --- green leafy vegetables --- effect of cooking --- polyphenols --- antioxidant activity --- Averrhoa bilimbi --- Oxalidaceae --- DPPH --- xanthine oxidase --- LC-QTOF-MS/MS --- molecular docking --- tentative bioactive constituents --- Dialium indum --- exocarp --- seed --- antioxidant --- phenolic acids --- amino acids --- GC-MS analysis --- AGN --- FIR --- phenolic --- flavonoid --- antioxidant capacity --- antimicrobial activity --- polyphenol compounds --- bixin --- rosemary extracts --- method validation --- HPLC --- food matrices --- fruit vinegar --- phenolics --- organic acid --- Ladastacho --- characterisation --- properties --- HPLC/ESI-MS --- HS-SPME/GC-MS --- beneficial use --- antimicrobial --- hydroxytyrosol --- rosemary --- pomegranate --- fish --- volatile compounds --- Rosa canina --- Rosa sempervivens --- Pyrocantha coccinea --- antioxidants --- endothelial cells --- glutathione --- almond skins --- bioavailability --- waste by-products --- flavonoids --- oxidative stress --- human --- reactive oxygen species --- proinflammatory cytokines --- Alzheimer’s disease --- cornelian cherry --- anthocyanins --- gastrointestinal digestion --- Opuntia ficus-indica cladode --- antibiofilm activity --- olive --- Olea europaea --- anthocyanin --- cyanidin 3-glucoside --- cyanidin 3-rutinoside --- oxygen radical absorbance capacity (ORAC) --- high performance liquid chromatography mass spectrometry (HPLC-MS). --- tea --- Camellia sinensis --- polyphenol --- catechin --- caffeine --- theaflavine --- insulin resistance --- diabetes --- olive oil --- phenols --- antidiabetic --- myrtle --- ultrasound-assisted extraction --- phenolic compounds --- liquid chromatography analysis --- mass spectrometry --- mulberry (Morus nigra --- Morus alba) --- simple sugars --- organic acids --- phenol compounds --- high performance liquid chromatography/diode array detector/mass spectrometry anthocyanins --- anti-inflammatory activity --- extraction --- central composite design --- optimization --- P. officinalis --- phytochemicals --- cytotoxicity --- α-amylase inhibition --- red-osier dogwood --- antioxidative effect --- H2O2 --- transepithelial resistance (TEER) --- Caco-2 cells --- Rubus idaeus L. --- HPLC-ESI-HR-qTOF-MS/MS --- antioxidant activities --- digestive enzymes inhibitors --- molecular docking analysis --- olive mill wastewater --- encapsulation --- maltodextrin --- whey protein --- gelatin --- spray drying --- diabetes mellitus --- Lamiaceae --- alpha-glucosidase --- alpha-amylase --- Salvia africana-lutea --- terpenoids --- cape floristic region --- n/a --- Alzheimer's disease --- Disaster Bay / Green Cape (NSW Far S Coast SJ55-08)
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“Antioxidant Activity of Polyphenolic Plant Extracts” is a collection of scientific articles regarding polyphenols, that is, substances occurring naturally in plants and exhibiting many beneficial effects on human health. Among polyphenols’ interesting biological properties, their antioxidant activity is considered the most important. This book brings together experts from different research fields on topics related to polyphenols, such as their isolation and purification, assessment of their antioxidant activity, prevention from oxidative stress-induced diseases and use as food additives. The polyphenols used in the present studies are derived from a great variety of plants, ranging from well-known species to rare ones that are only found in specific regions. Moreover, some of the studies provide evidence that polyphenols may be used for the prevention and treatment of common diseases such as diabetes mellitus, Alzheimers’ disease, cardiovascular and intestinal diseases. Importantly, in several of the studies “green extraction methods” for the isolation of polyphenols were developed using modern technologies, where few or no organic solvents were used, in order to minimize environmental and health impacts.
green leafy vegetables --- effect of cooking --- polyphenols --- antioxidant activity --- Averrhoa bilimbi --- Oxalidaceae --- DPPH --- xanthine oxidase --- LC-QTOF-MS/MS --- molecular docking --- tentative bioactive constituents --- Dialium indum --- exocarp --- seed --- antioxidant --- phenolic acids --- amino acids --- GC-MS analysis --- AGN --- FIR --- phenolic --- flavonoid --- antioxidant capacity --- antimicrobial activity --- polyphenol compounds --- bixin --- rosemary extracts --- method validation --- HPLC --- food matrices --- fruit vinegar --- phenolics --- organic acid --- Ladastacho --- characterisation --- properties --- HPLC/ESI-MS --- HS-SPME/GC-MS --- beneficial use --- antimicrobial --- hydroxytyrosol --- rosemary --- pomegranate --- fish --- volatile compounds --- Rosa canina --- Rosa sempervivens --- Pyrocantha coccinea --- antioxidants --- endothelial cells --- glutathione --- almond skins --- bioavailability --- waste by-products --- flavonoids --- oxidative stress --- human --- reactive oxygen species --- proinflammatory cytokines --- Alzheimer’s disease --- cornelian cherry --- anthocyanins --- gastrointestinal digestion --- Opuntia ficus-indica cladode --- antibiofilm activity --- olive --- Olea europaea --- anthocyanin --- cyanidin 3-glucoside --- cyanidin 3-rutinoside --- oxygen radical absorbance capacity (ORAC) --- high performance liquid chromatography mass spectrometry (HPLC-MS). --- tea --- Camellia sinensis --- polyphenol --- catechin --- caffeine --- theaflavine --- insulin resistance --- diabetes --- olive oil --- phenols --- antidiabetic --- myrtle --- ultrasound-assisted extraction --- phenolic compounds --- liquid chromatography analysis --- mass spectrometry --- mulberry (Morus nigra --- Morus alba) --- simple sugars --- organic acids --- phenol compounds --- high performance liquid chromatography/diode array detector/mass spectrometry anthocyanins --- anti-inflammatory activity --- extraction --- central composite design --- optimization --- P. officinalis --- phytochemicals --- cytotoxicity --- α-amylase inhibition --- red-osier dogwood --- antioxidative effect --- H2O2 --- transepithelial resistance (TEER) --- Caco-2 cells --- Rubus idaeus L. --- HPLC-ESI-HR-qTOF-MS/MS --- antioxidant activities --- digestive enzymes inhibitors --- molecular docking analysis --- olive mill wastewater --- encapsulation --- maltodextrin --- whey protein --- gelatin --- spray drying --- diabetes mellitus --- Lamiaceae --- alpha-glucosidase --- alpha-amylase --- Salvia africana-lutea --- terpenoids --- cape floristic region --- n/a --- Alzheimer's disease --- Disaster Bay / Green Cape (NSW Far S Coast SJ55-08)
Choose an application
“Antioxidant Activity of Polyphenolic Plant Extracts” is a collection of scientific articles regarding polyphenols, that is, substances occurring naturally in plants and exhibiting many beneficial effects on human health. Among polyphenols’ interesting biological properties, their antioxidant activity is considered the most important. This book brings together experts from different research fields on topics related to polyphenols, such as their isolation and purification, assessment of their antioxidant activity, prevention from oxidative stress-induced diseases and use as food additives. The polyphenols used in the present studies are derived from a great variety of plants, ranging from well-known species to rare ones that are only found in specific regions. Moreover, some of the studies provide evidence that polyphenols may be used for the prevention and treatment of common diseases such as diabetes mellitus, Alzheimers’ disease, cardiovascular and intestinal diseases. Importantly, in several of the studies “green extraction methods” for the isolation of polyphenols were developed using modern technologies, where few or no organic solvents were used, in order to minimize environmental and health impacts.
Research & information: general --- Biology, life sciences --- green leafy vegetables --- effect of cooking --- polyphenols --- antioxidant activity --- Averrhoa bilimbi --- Oxalidaceae --- DPPH --- xanthine oxidase --- LC-QTOF-MS/MS --- molecular docking --- tentative bioactive constituents --- Dialium indum --- exocarp --- seed --- antioxidant --- phenolic acids --- amino acids --- GC-MS analysis --- AGN --- FIR --- phenolic --- flavonoid --- antioxidant capacity --- antimicrobial activity --- polyphenol compounds --- bixin --- rosemary extracts --- method validation --- HPLC --- food matrices --- fruit vinegar --- phenolics --- organic acid --- Ladastacho --- characterisation --- properties --- HPLC/ESI-MS --- HS-SPME/GC-MS --- beneficial use --- antimicrobial --- hydroxytyrosol --- rosemary --- pomegranate --- fish --- volatile compounds --- Rosa canina --- Rosa sempervivens --- Pyrocantha coccinea --- antioxidants --- endothelial cells --- glutathione --- almond skins --- bioavailability --- waste by-products --- flavonoids --- oxidative stress --- human --- reactive oxygen species --- proinflammatory cytokines --- Alzheimer's disease --- cornelian cherry --- anthocyanins --- gastrointestinal digestion --- Opuntia ficus-indica cladode --- antibiofilm activity --- olive --- Olea europaea --- anthocyanin --- cyanidin 3-glucoside --- cyanidin 3-rutinoside --- oxygen radical absorbance capacity (ORAC) --- high performance liquid chromatography mass spectrometry (HPLC-MS). --- tea --- Camellia sinensis --- polyphenol --- catechin --- caffeine --- theaflavine --- insulin resistance --- diabetes --- olive oil --- phenols --- antidiabetic --- myrtle --- ultrasound-assisted extraction --- phenolic compounds --- liquid chromatography analysis --- mass spectrometry --- mulberry (Morus nigra --- Morus alba) --- simple sugars --- organic acids --- phenol compounds --- high performance liquid chromatography/diode array detector/mass spectrometry anthocyanins --- anti-inflammatory activity --- extraction --- central composite design --- optimization --- P. officinalis --- phytochemicals --- cytotoxicity --- α-amylase inhibition --- red-osier dogwood --- antioxidative effect --- H2O2 --- transepithelial resistance (TEER) --- Caco-2 cells --- Rubus idaeus L. --- HPLC-ESI-HR-qTOF-MS/MS --- antioxidant activities --- digestive enzymes inhibitors --- molecular docking analysis --- olive mill wastewater --- encapsulation --- maltodextrin --- whey protein --- gelatin --- spray drying --- diabetes mellitus --- Lamiaceae --- alpha-glucosidase --- alpha-amylase --- Salvia africana-lutea --- terpenoids --- cape floristic region --- Disaster Bay / Green Cape (NSW Far S Coast SJ55-08)
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