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Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable biological potency and the diversity of roles they play in the physiological and pathological changes of cells and tissues. This book is a comprehensive compendium of the latest research on the molecular mechanisms of KLFs, describing their roles in transcriptional regulation, cellular differentiation and development, the pathogenesis of the liver and cardiovascular systems and cancer, and generation of ES cells and iPS cells. As the only concise treatise written to date by leading experts in the field, it serves as an authoritative review of this family of molecules and is an essential reference for all who are interested in KLFs. The book also explores the potential of KLFs as targets for novel therapeutics and diagnostics, and will be invaluable in those fields.

DNA-binding proteins. --- Genetic regulation. --- Genomics. --- Medical genetics. --- Transcription factors. --- Genomics --- DNA-binding proteins --- Transcription factors --- Gene regulatory networks --- Medical genetics --- Kruppel-Like Transcription Factors --- Gene Regulatory Networks --- Physiology --- Genetics --- Zinc Fingers --- Biology --- Amino Acid Motifs --- Biological Science Disciplines --- DNA-Binding Proteins --- Regulatory Sequences, Nucleic Acid --- Transcription Factors --- Base Sequence --- Proteins --- Protein Structure, Secondary --- Natural Science Disciplines --- Disciplines and Occupations --- Protein Conformation --- Genetic Structures --- Amino Acids, Peptides, and Proteins --- Genetic Phenomena --- Molecular Conformation --- Chemicals and Drugs --- Phenomena and Processes --- Molecular Structure --- Biochemical Phenomena --- Chemical Phenomena --- Cytology --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Cells --- Cytology. --- Molecular biology. --- Growth. --- Molecular biochemistry --- Molecular biophysics --- Cell biology --- Cellular biology --- Cell growth --- Life sciences. --- Cancer research. --- Cell biology. --- Developmental biology. --- Animal genetics. --- Animal physiology. --- Life Sciences. --- Cell Biology. --- Animal Genetics and Genomics. --- Animal Physiology. --- Cancer Research. --- Developmental Biology. --- Molecular Medicine. --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cytologists --- Cell proliferation --- Oncology. --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Development (Biology) --- Growth --- Ontogeny --- Tumors --- Animal physiology --- Animals --- Anatomy --- Health Workforce --- Cancer research