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Accelerated cardiovascular disease is a frequent complication of chronic kidney disease. Individuals with evidence of renal functional impairment are more likely to die of cardiovascular events than to progress to end stage renal disease. This relationship, which has been termed the cardiorenal syndrome, exists whether impairment of renal function is a consequence of primary renal parenchymal or primary heart disease. The mechanisms underlying the cardiorenal syndrome result from a complex interaction of traditional and uremia related cardiovascular risk factors. Prevention and management of cardiovascular disease include aggressive control of traditional risk factors as well novel approach to prevent or reverse uremia related processes. Chronic kidney disease with a worldwide prevalence of 10% in the general population is emerging as a major public health priority. Renal dysfunction is associated with a high risk for cardiovascular complications. The relationship between renal insufficiency and cardiovascular disease, termed the cardiorenal syndrome exists whether impairment of renal function is a consequence of primary renal parenchymal disease or primary heart disease. This book provides a comprehensive update analysis of our current understanding of the cardiorenal syndrome, including epidemiology, pathophysiologic mechanisms, and therapeutic approaches.
Cardiovascular system -- Diseases -- Risk factors. --- Cardiovascular system -- Diseases -- Treatment. --- Kidneys -- Diseases -- Risk factors. --- Kidneys -- Diseases -- Treatment. --- Cardiovascular system --- Kidneys --- Diseases --- Renal Insufficiency, Chronic --- Renal Insufficiency --- Kidney Failure, Chronic --- Cardiovascular Diseases --- Kidney Diseases --- Urologic Diseases --- Male Urogenital Diseases --- Female Urogenital Diseases --- Female Urogenital Diseases and Pregnancy Complications --- Medicine --- Health & Biological Sciences --- Risk factors --- Treatment --- Risk factors. --- Treatment. --- Medicine. --- Cardiology. --- Nephrology. --- Medicine & Public Health. --- Abdomen --- Urinary organs --- Nephrology --- Internal medicine --- Heart
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Conditions such as oxidative stress and hypoxia, which have a generalized impact on the oxygen metabolism, have been implicated in the genesis of kidney disease. This means that deepening our understanding of the pathobiology of oxygen metabolism in such diseases could be a fruitful path towards tangible clinical benefits. Studies in Renal Disorder collects reviews from leading researchers and clinical scientists working in exactly this field, providing an overview of the latest advances. The causal role of impaired oxygen metabolism in kidney disease has numerous clinical implications. It affects our understanding of the therapeutic benefits accruing from anti-hypertensive agents; the way we control hyperglycemia/hyperinsulinemia and hyperlipidemia; and our use of dietary approaches to the correction of obesity. The defensive mechanisms against oxidative stress, such as the Nrf2-Keap1 system, and hypoxia, such as the PHD-HIF system, have recently been explored in various cells, including kidney cells. These mechanisms include intracellular sensors for oxidative stress and hypoxia. This means that novel approaches targeting these sensors may offer clinical benefits in kidney disease in which oxidative stress and/or hypoxia is a final, common pathway.
Kidneys -- Diseases -- Treatment. --- Kidneys -- Diseases. --- Kidneys. --- Kidneys --- Oxidative stress --- Anoxemia --- Signs and Symptoms, Respiratory --- Stress, Physiological --- Urologic Diseases --- Metabolic Phenomena --- Phenomena and Processes --- Female Urogenital Diseases --- Physiological Processes --- Signs and Symptoms --- Male Urogenital Diseases --- Pathological Conditions, Signs and Symptoms --- Female Urogenital Diseases and Pregnancy Complications --- Diseases --- Physiological Phenomena --- Kidney Diseases --- Anoxia --- Oxidative Stress --- Metabolism --- Biology --- Medicine --- Health & Biological Sciences --- Urology & Nephrology --- Cytology --- Pathophysiology --- Research. --- Treatment. --- Life sciences. --- Nephrology. --- Cell biology. --- Oxidative stress. --- Life Sciences. --- Oxidative Stress. --- Cell Biology. --- Abdomen --- Urinary organs --- Nephrology --- Cytology. --- Internal medicine --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Anoxemi --- Oxidation-reduction reaction --- Stress (Physiology)
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Competency based critical care: Renal Increased recognition of the overlap between critical care and renal medicine, and recent advances in the understanding of acute renal failure and the application of renal replacement therapies, have brought increased attention to the nephrologist's role in the intensive care unit. This book covers all aspects of the renal system as seen from this perspective, including causes and management of acute kidney injury, end-stage kidney disease and renal replacement therapies. The volume is written to provide an approach for the resident in nephrology, and recent advances are highlighted in the text, also making this text a useful reference to those already established within the field of critical care. Key features include: - Concise and complete book for the learning resident. - Multidisciplinary relevance, offering clear explanations of each department and discipline’s role in the overall treatment process, making focused and contextual reading easier. - Accessible format making the process of self-directed learning as user friendly as possible. - Up-to-date chapters written and edited by expert practitioners in the field, to complete a contemporary text that will be of use to trainees and specialists alike.
Medicine & Public Health. --- Nephrology. --- Transplant Surgery. --- Intensive / Critical Care Medicine. --- Emergency Medicine. --- Medicine. --- Emergency medicine. --- Critical care medicine. --- Transplantation of organs, tissues, etc. --- Médecine --- Médecine d'urgence --- Soins intensifs --- Néphrologie --- Greffe (Chirurgie) --- Acute renal failure -- Treatment. --- Acute renal failure. --- Kidneys -- Diseases -- Treatment. --- Kidneys -- Diseases. --- Kidneys --- Acute renal failure --- Renal Insufficiency --- Acute Kidney Injury --- Kidney Diseases --- Urologic Diseases --- Male Urogenital Diseases --- Female Urogenital Diseases --- Diseases --- Female Urogenital Diseases and Pregnancy Complications --- Medicine --- Urology & Nephrology --- Health & Biological Sciences --- Treatment --- Diseases. --- Treatment. --- Acute kidney failure --- Acute renal insufficiency --- Kidney failure, Acute --- Renal failure, Acute --- Renal insufficiency, Acute --- Kidney diseases --- Nephritis --- Nephropathy --- Renal diseases --- Surgical transplantation. --- Transplantation of organs, tissu. --- Medical transplantation --- Organ transplantation --- Organ transplants --- Organs (Anatomy) --- Surgical transplantation --- Tissue transplantation --- Tissues --- Transplants, Organ --- Surgery --- Preservation of organs, tissues, etc. --- Procurement of organs, tissues, etc. --- Medicine, Emergency --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Intensive care --- Intensive medicine --- Emergency medicine --- Intensive care units --- Internal medicine --- Transplantation --- Transplant surgery --- Transplantation surgery
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