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Lanthanum --- Tight junctions (Cell biology) --- Junctions, Tight (Cell biology) --- Pentilaminar junctions (Cell biology) --- Zonula occludens --- Cell junctions --- Junctional complexes (Epithelium) --- Cerium group --- Physiological effect. --- Therapeutic use. --- Research --- Methodology.

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The Paracellular Channel: Biology, Physiology and Disease serves as the first volume to offer a cohesive and unifying picture of the critical functions of paracellular channels (tight junctions) in different tissues. This new class of ion channel utilizes a completely different mechanism to create ion passage pathways across the cell junction. This volume outlines common principles that govern the organization and regulation of these diverse cellular structures, describes the methodology of study, and highlights the pathophysiologic consequence of abnormal structure and functions of the paracellular channels in human diseases. Coverage includes biochemical, biophysical, structural, physiologic analyses of the paracellular channel, and new technologies for recording and characterization.--

Membranes (Biology) --- Tight junctions (Cell biology) --- Membrane proteins. --- Proteins --- Junctions, Tight (Cell biology) --- Pentilaminar junctions (Cell biology) --- Zonula occludens --- Cell junctions --- Junctional complexes (Epithelium) --- Biological membranes --- Biomembranes --- Biological interfaces --- Protoplasm

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There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.

Metastasis. --- Neoplasm Metastasis -- physiopathology. --- Neoplasm Metastasis -- therapy. --- Metastasis --- Neoplastic Processes --- Intercellular Junctions --- Neoplasms --- Cell Membrane Structures --- Diseases --- Cell Membrane --- Cellular Structures --- Cells --- Anatomy --- Neoplasm Metastasis --- Tight Junctions --- Tight junctions (Cell biology) --- Molecular aspects. --- Cancer --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Junctions, Tight (Cell biology) --- Pentilaminar junctions (Cell biology) --- Zonula occludens --- Dissemination --- Medicine. --- Cancer research. --- Oncology. --- Cell biology. --- Cell membranes. --- Biomedicine. --- Biomedicine general. --- Cancer Research. --- Cell Biology. --- Membrane Biology. --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Cell junctions --- Junctional complexes (Epithelium) --- Oncology  . --- Cytology. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Health Workforce --- Cell membranes . --- Biomedicine, general. --- Cancer research