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Asthma --- Bronchial hyperactivity --- Dendritic cells --- Intracellular signaling peptides and proteins --- immunology --- physiology

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Hirschsprung Disease --- Carrier Proteins --- Intracellular Signaling Peptides and Proteins --- genetics --- metabolism

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Signal Transduction --- Amino Acid Sequence --- Intercellular Signaling Peptides and Proteins --- Intracellular Signaling Peptides and Proteins --- Cellular signal transduction --- Transduction du signal cellulaire --- physiology --- 576 --- Cellular and subcellular biology. Cytology --- 576 Cellular and subcellular biology. Cytology --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- physiology. --- Signal Transduction - physiology --- Amino Acid Sequence - physiology --- Intercellular Signaling Peptides and Proteins - physiology --- Intracellular Signaling Peptides and Proteins - physiology

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This volume is an in-depth treatment of G-Protein Signaling, Part A, and will cover general methods of analysis of RGS protein analysis, including Expression and post-translational modification, Assays of GAP activity and allosteric control, Electrophysiological methods and RGS-insensitive Ga subunits, Mouse models of RGS protein action, Methods of RGS protein inhibition, and G-protein regulators of model organisms.Table of Contents-Expression and post-translational modification-Assays of GAP activity and allosteric control-Electrophysiological methods and RGS-insenstitive

Biochemistry -- Periodicals. --- Biochemistry -- Technique. --- Enzymes -- Periodicals. --- Enzymes. --- G proteins. --- RGS Proteins. --- Intracellular Signaling Peptides and Proteins --- RGS Proteins --- GTP-Binding Protein Regulators --- GTPase-Activating Proteins --- Proteins --- Peptides --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Polypeptides --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Regulating Factors, G-Protein --- Regulating Factors, GTP-Binding Protein --- G-Protein Regulating Factors --- G-Protein Signaling Regulators --- Regulators, G-Protein Signaling --- G Protein Regulating Factors --- G Protein Signaling Regulators --- GTP Binding Protein Regulators --- Regulating Factors, GTP Binding Protein --- Regulators, G Protein Signaling --- Regulators, GTP-Binding Protein --- Signaling Regulators, G-Protein --- Intracellular Signaling Peptides --- Intracellular Signaling Proteins --- Peptides, Intracellular Signaling --- Proteins, Intracellular Signaling --- Signaling Peptides, Intracellular --- Signaling Proteins, Intracellular --- GAP Protein --- GTPase-Activating Protein --- GAP Proteins --- GTPase Activating Protein --- GTPase Activating Proteins --- RGS Protein (G-Protein Signaling) --- Regulators of G-Protein Signaling Proteins --- Regulators of G Protein Signaling Proteins --- Cell physiology. --- Cellular control mechanisms. --- Proteins. --- Stress (Physiology). --- Molecular Mechanisms of Pharmacological Action --- Peptide --- Polypeptide --- Protein --- Membrane proteins.

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Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.  .

Genes. --- Human molecular genetics --- Protein-protein interactions --- Cellular signal transduction --- Peptides --- Proteins --- Biological Science Disciplines --- Metabolic Phenomena --- Physiological Processes --- Natural Science Disciplines --- Physiological Phenomena --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Chemicals and Drugs --- Disciplines and Occupations --- Stress, Physiological --- Cell Cycle Proteins --- Intracellular Signaling Peptides and Proteins --- Metabolism --- Physiology --- Medicine --- Biology --- Health & Biological Sciences --- Pathology --- Genetics --- Medicine. --- Human genetics. --- Medical genetics. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Clinical genetics --- Diseases --- Heredity of disease --- Clinical sciences --- Medical profession --- Composition --- Genetic aspects --- Biomedicine. --- Gene Function. --- Biochemistry, general. --- Human Genetics. --- Chemistry --- Medical sciences --- Human genetics --- Genetic disorders --- Heredity, Human --- Human biology --- Physical anthropology --- Life sciences --- Physicians