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Protein interactions, which include interactions between proteins and other biomolecules, are essential to all aspects of biological processes, such as cell growth, differentiation, and apoptosis. Therefore, investigation and modulation of protein interactions are of significance as it not only reveals the mechanism governing cellular activity, but also leads to potential agents for the treatment of various diseases. The objective of this book is to highlight some of the latest approaches in the study of protein interactions, including modulation of protein interactions, development of analytical techniques, etc. Collectively they demonstrate the importance and the possibility for the further investigation and modulation of protein interactions as technology is evolving.

Protein-protein interactions. --- Interactions, Protein-protein --- PPIs (Protein-protein interactions) --- Protein interactions --- Interactomes --- Molecular association --- Biochemistry

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Protein-protein interactions --- Proteins --- Interactions, Protein-protein --- Protein interactions --- Molecular association --- metabolism --- General biophysics --- PPIs (Protein-protein interactions) --- Interactomes

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The chapters in this book are written by a team of well-reputed international researchers. The objective is to provide advanced and updated information related to protein-protein interactions. I hope the methods, resources and approaches described here will enhance the available knowledge of the reader significantly.

Protein-protein interactions. --- Interactions, Protein-protein --- PPIs (Protein-protein interactions) --- Protein interactions --- Interactomes --- Molecular association --- Life Sciences --- Immunology and Microbiology --- Structural Biology --- Proteomics

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Protein-protein interactions. --- Proteins. --- Carrier proteins. --- Binding proteins --- Transport proteins --- Biological transport --- Protein binding --- Proteins --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Interactions, Protein-protein --- Protein interactions --- Molecular association --- PPIs (Protein-protein interactions) --- Interactomes

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"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces, as well as including details of experimental and computational tools to tackle the subject, and highlighting the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces.

Chemistry. --- Chemistry, Organic. --- Crosslinked polymers. --- Polymer networks. --- Polymers. --- Protein-protein interactions --- Investigative Techniques --- Amino Acids, Peptides, and Proteins --- Biochemical Processes --- Biochemical Phenomena --- Chemicals and Drugs --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemical Phenomena --- Phenomena and Processes --- Protein Binding --- Proteins --- Drug Discovery --- Chemistry --- Physical Sciences & Mathematics --- Biochemistry --- Protein-protein interactions. --- Interactions, Protein-protein --- Protein interactions --- Organic chemistry. --- Organic Chemistry. --- Molecular association --- Organic chemistry