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In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-

Macrophage migration inhibitory factor. --- Macrophages. --- Histiocytes --- Mononuclear phagocytes --- Antigen presenting cells --- Connective tissue cells --- Killer cells --- Phagocytes --- Reticulo-endothelial system --- Inhibition factor, Macrophage migration --- Inhibitory factor, Macrophage migration --- Macrophage migration inhibition factor --- MIF (Macrophage migration inhibitory factor) --- Migration inhibition factor, Macrophage --- Migration inhibitory factor, Macrophage --- Lymphokines