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Influenza vaccines --- Nervous system --- Influenza virus vaccines --- Viral vaccines --- Neuroimmunology --- Side effects. --- Diseases --- Immunological aspects.
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The threat constituted by the multiple outbreaks of avian influenza during the last few years is urgently calling for the development of new influenza vaccines. Fortunately, a quantum leap in technology has revolutionized the study of influenza and the engineering of new vaccine strains by reverse genetics. This volume provides a historical background and state-of-the-art information about the recent advances in the biology of influenza and the design of new influenza vaccines.
Influenza vaccines. --- Influenza. --- Influenza viruses. --- Orthomyxoviruses --- Flu --- Flu, Respiratory --- Grippe --- Respiratory flu --- Respiratory infections --- Virus diseases --- Influenza virus vaccines --- Viral vaccines --- Medical virology. --- Life sciences. --- Virology. --- Life Sciences, general. --- Biosciences --- Sciences, Life --- Science --- Medical microbiology --- Virology --- Microbiology
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Influenza vaccines. --- Influenza viruses. --- Influenza. --- Influenza --- Influenza vaccines --- Influenza viruses --- Orthomyxoviruses --- Influenza virus vaccines --- Viral vaccines --- Flu --- Flu, Respiratory --- Grippe --- Respiratory flu --- Respiratory infections --- Virus diseases --- INFLUENZAVIRUS A --- RNA VIRUSES --- INFLUENZA, HUMAN --- INFLUENZA VACCINES --- METABOLISM --- IMMUNOLOGY --- PATHOGENICITY --- HISTORY
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Influenza vaccines. --- Influenza viruses. --- Influenza. --- Influenza, Human --- Orthomyxoviridae. --- Viral Nonstructural Proteins. --- virology. --- Influenza --- Influenza vaccines --- Influenza viruses --- Orthomyxoviruses --- Influenza virus vaccines --- Viral vaccines --- Flu --- Flu, Respiratory --- Grippe --- Respiratory flu --- Respiratory infections --- Virus diseases --- Influenza, human
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Chickens cannot be bought in Vietnam restaurants for love or money. New reports are emerging every week of the global reach of avian influenza in birds. Africa and Europe are now affected by what was thought to be an Asian poultry disease. Governments worldwide are stockpiling antiviral drugs and forming rationing plans. Citizens are concerned that they will not be in "the list" of those who will receive these wonder drugs. Reports are emerging of antiviral drug resistance as the influenza virus mutates.What is the influenza virus? Why are people so worried about pandemic influenza? What is a
Avian influenza. --- SARS (Disease) --- Influenza --- Influenza vaccines. --- Influenza virus vaccines --- Viral vaccines --- Flu --- Flu, Respiratory --- Grippe --- Respiratory flu --- Respiratory infections --- Virus diseases --- Acute respiratory syndrome, Severe --- Respiratory syndrome, Severe acute --- Severe acute respiratory syndrome --- Coronavirus infections --- Syndromes --- Avian flu --- Bird flu --- Fowl pest --- Fowl plague --- Influenza in birds --- Birds --- Poultry --- Prevention.
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The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.
Influenza A virus -- Immunology. --- Influenza B virus -- Immunology. --- Influenza Vaccines -- Therapeutic use. --- Influenza vaccines. --- Influenza viruses. --- Influenza, Human. --- Influenza vaccines --- Influenza --- Influenza viruses --- Orthomyxoviridae Infections --- Influenza A virus --- Respiratory Tract Infections --- Viral Vaccines --- Respiratory Tract Diseases --- Vaccines --- RNA Virus Infections --- Influenzavirus A --- Influenza A Virus, H1N1 Subtype --- Influenza Vaccines --- Influenza, Human --- Orthomyxoviridae --- Virus Diseases --- Diseases --- Biological Products --- RNA Viruses --- Complex Mixtures --- Chemicals and Drugs --- Vertebrate Viruses --- Viruses --- Organisms --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Influenza. --- Flu --- Flu, Respiratory --- Grippe --- Respiratory flu --- Influenza virus vaccines --- Medicine. --- Virology. --- Life sciences. --- Biomedicine. --- Life Sciences, general. --- Orthomyxoviruses --- Respiratory infections --- Virus diseases --- Viral vaccines --- Medical virology. --- Biosciences --- Sciences, Life --- Science --- Medical microbiology --- Virology --- Microbiology
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Recent years have seen unprecedented outbreaks of avian influenza A viruses. In particular, highly pathogenic H5N1 viruses have not only resulted in widespread outbreaks in domestic poultry, but have been transmitted to humans resulting in numerous fatalities. The rapid expansion in their geographic distribution and the possibility that these viruses could acquire the ability to spread from person to person raise the risk that such a virus could cause a global pandemic with high morbidity and mortality. An effective influenza vaccine represents the best approach to prevent and control such an emerging pandemic. However, current influenza vaccines are directed at existing seasonal influenza viruses, which have limited antigenic relationships to the highly pathogenic H5N1 strains. Concerns about pandemic preparedness have greatly stimulated research activities to develop effective vaccines for pandemic influenza viruses, and to overcome the limitations inherent in current approaches to vaccine production and distribution. These limitations include the use of embryonated chicken eggs as the substrate for vaccine production; which is time-consuming and could involve potential biohazards in growth of new virus strains. Other limitations include the requirement that the current inactivated influenza vaccines be administered using needles and syringes, requiring trained personnel, which could be a bottleneck when attempting to vaccinate large populations in mass campaigns. In addition, the current inactivated vaccines which are delivered by injection elicit limited protective immunity in the upper respiratory tract where the infection process is initiated. Most of these limitations of the current vaccines are being addressed by research on novel approaches to vaccine development and delivery that are described in many of the chapters in this volume.
Disease Outbreaks. --- Influenza vaccines. --- Influenza Vaccines -- therapeutic use. --- Influenza, Human. --- Influenzavirus A. --- Influenza Vaccines --- Influenzavirus A --- Influenza, Human --- Disease Outbreaks --- Orthomyxoviridae --- Viral Vaccines --- Public Health --- Orthomyxoviridae Infections --- Respiratory Tract Infections --- Environment and Public Health --- RNA Viruses --- Vaccines --- Respiratory Tract Diseases --- RNA Virus Infections --- Diseases --- Biological Products --- Virus Diseases --- Viruses --- Health Care --- Vertebrate Viruses --- Complex Mixtures --- Organisms --- Chemicals and Drugs --- Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Viral vaccines. --- Virus vaccines --- Influenza virus vaccines --- Medicine. --- Immunology. --- Pharmacology. --- Virology. --- Public health. --- Biomedicine. --- Pharmacology/Toxicology. --- Public Health. --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Sanitary affairs --- Social hygiene --- Health --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation --- Microbiology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Physiological effect --- Viral vaccines --- Medical virology. --- Toxicology. --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Medical microbiology --- Virology --- Virus diseases --- Toxicology
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Reports of influenza-like illnesses date back to the Middle Ages, and outbreaks of influenza likely afflicted humans long before that. Over the last half century, influenza virus research has led to the development of two classes of antivirals – ion channel and neuraminidase inhibitors. Recently, a method of the artificial generation of an influenza virus was established. This system has been instrumental in the development of novel influenza vaccines and in the understanding of viral pathogenicity and the functions of viral proteins. Influenza Virus: Methods and Protocols summarizes the current techniques that have made this progress possible, ranging from protocols for virus isolation, growth, and subtyping to procedures for the efficient generation of any influenza virus. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Influenza Virus: Methods and Protocols seeks to serve both professionals and novices with the techniques used in numerous laboratories around the world that are, thus, the building blocks that underpin almost all influenza virus research.
Influenza --- Influenza viruses --- Influenza vaccines --- Investigative Techniques --- Physiological Processes --- Publication Formats --- Microbiology --- RNA Virus Infections --- RNA Viruses --- Respiratory Tract Infections --- Viral Vaccines --- Publication Characteristics --- Respiratory Tract Diseases --- Vaccines --- Physiological Phenomena --- Vertebrate Viruses --- Viruses --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biology --- Virus Diseases --- Biological Products --- Diseases --- Biological Science Disciplines --- Phenomena and Processes --- Organisms --- Natural Science Disciplines --- Complex Mixtures --- Disciplines and Occupations --- Chemicals and Drugs --- Methods --- Influenza Vaccines --- Orthomyxoviridae Infections --- Laboratory Manuals --- Virology --- Orthomyxoviridae --- Growth and Development --- Influenza, Human --- Medicine --- Health & Biological Sciences --- Microbiology & Immunology --- Infectious Diseases --- Influenza. --- Grippe --- Influenzavirus --- Vaccins antigrippaux --- growth & development --- Laboratory manuals. --- isolation & purification --- methods --- Complex Extracts --- Crude Extracts --- Extracts, Complex --- Extracts, Crude --- Mixtures, Complex --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Biologic Products --- Products, Biological --- Biologics --- Natural Products --- Products, Biologic --- Products, Natural --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Animal Viruses --- Zoophaginae --- Animal Virus --- Virus --- Virus, Animal --- Viruses, Animal --- Physiological Concepts --- Physiological Phenomenon --- Physiological Process --- Concept, Physiological --- Concepts, Physiological --- Phenomena, Physiological --- Phenomenas, Physiological --- Phenomenon, Physiological --- Physiological Concept --- Process, Physiological --- Processes, Physiological --- Disease, Respiratory Tract --- Diseases, Respiratory Tract --- Respiratory Tract Disease --- Tract Disease, Respiratory --- Tract Diseases, Respiratory --- Vaccines, Viral --- Infections, Respiratory --- Infections, Respiratory Tract --- Infections, Upper Respiratory --- Infections, Upper Respiratory Tract --- Respiratory Infections --- Upper Respiratory Infections --- Upper Respiratory Tract Infections --- Infection, Respiratory Tract --- Respiratory Infection, Upper --- Respiratory Tract Infection --- RNA Rodent Viruses --- RNA Rodent Virus --- RNA Virus --- Rodent Virus, RNA --- Rodent Viruses, RNA --- Virus, RNA --- Virus, RNA Rodent --- Viruses, RNA --- Viruses, RNA Rodent --- Infections, RNA Virus --- Infection, RNA Virus --- RNA Virus Infection --- Virus Infection, RNA --- Virus Infections, RNA --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Influenza virus vaccines --- Flu --- Flu, Respiratory --- Respiratory flu --- Human Flu --- Human Influenza --- Influenza in Humans --- Flu, Human --- Human Influenzas --- Influenza in Human --- Influenzas --- Influenzas, Human --- Development and Growth --- Orthomyxoviruses --- Influenza Viruses --- Myxoviruses --- Influenza Virus --- Myxovirus --- Orthomyxovirus --- Infections, Orthomyxoviridae --- Infections, Orthomyxovirus --- Orthomyxovirus Infections --- Infection, Orthomyxoviridae --- Infection, Orthomyxovirus --- Orthomyxoviridae Infection --- Orthomyxovirus Infection --- Afluria --- CAIV-T vaccine --- Flu Vaccines --- FluMist --- Influenza Vaccine --- Influenza Virus Vaccines --- Influenzavirus Vaccines --- LAIV vaccine --- Trivalent Live Attenuated Influenza Vaccine --- Vaccine, Influenza --- Vaccines, Flu --- Vaccines, Influenza --- Vaccines, Influenza Virus --- Vaccines, Influenzavirus --- Virus Vaccines, Influenza --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Medicine. --- Virology. --- Infectious diseases. --- Medicine & Public Health. --- Infectious Diseases. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Emerging infectious diseases. --- Medical virology. --- Medical microbiology --- Virus diseases --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases
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