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Astrocytes are key cellular partners to neurons in the brain. They play an important role in multiple processes such as neurotransmitter recycling, trophic support, antioxidant defense, ionic homeostasis, inflammatory modulation, neurovascular and neurometabolic coupling, neurogenesis, synapse formation and synaptic plasticity. In addition to their crucial involvement in normal brain physiology, it is well known that astrocytes adopt a reactive phenotype under most acute and chronic pathological conditions such as ischemia, trauma, brain cancer, epilepsy, demyelinating and neurodegenerative diseases. However, the functional impact of astrocyte reactivity is still unclear. During the last decades, the development of innovative approaches to study astrocytes has significantly improved our understanding of their prominent role in brain function and their contribution to disease states. In particular, new genetic tools, molecular probes, and imaging techniques that achieve high spatial and temporal resolution have revealed new insight into astrocyte functions in situ. This Research Topic provides a collection of cutting-edge techniques, approaches and models to study astrocytes in health and disease. It also suggests new directions to achieve discoveries on these fascinating cells.
Astrocytes. --- Neurons --- brain imaging --- transgenesis --- high-resolution imaging --- gene transfer --- Reactive astrocytes --- Electrophysiology --- neuron-astrocyte interactions --- In vivo analysis --- Physiology. --- brain imaging --- transgenesis --- high-resolution imaging --- gene transfer --- Reactive astrocytes --- Electrophysiology --- neuron-astrocyte interactions --- In vivo analysis
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Astrocytes are key cellular partners to neurons in the brain. They play an important role in multiple processes such as neurotransmitter recycling, trophic support, antioxidant defense, ionic homeostasis, inflammatory modulation, neurovascular and neurometabolic coupling, neurogenesis, synapse formation and synaptic plasticity. In addition to their crucial involvement in normal brain physiology, it is well known that astrocytes adopt a reactive phenotype under most acute and chronic pathological conditions such as ischemia, trauma, brain cancer, epilepsy, demyelinating and neurodegenerative diseases. However, the functional impact of astrocyte reactivity is still unclear. During the last decades, the development of innovative approaches to study astrocytes has significantly improved our understanding of their prominent role in brain function and their contribution to disease states. In particular, new genetic tools, molecular probes, and imaging techniques that achieve high spatial and temporal resolution have revealed new insight into astrocyte functions in situ. This Research Topic provides a collection of cutting-edge techniques, approaches and models to study astrocytes in health and disease. It also suggests new directions to achieve discoveries on these fascinating cells.
Astrocytes. --- Neurons --- Physiology. --- brain imaging --- transgenesis --- high-resolution imaging --- gene transfer --- Reactive astrocytes --- Electrophysiology --- neuron-astrocyte interactions --- In vivo analysis
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Astrocytes are key cellular partners to neurons in the brain. They play an important role in multiple processes such as neurotransmitter recycling, trophic support, antioxidant defense, ionic homeostasis, inflammatory modulation, neurovascular and neurometabolic coupling, neurogenesis, synapse formation and synaptic plasticity. In addition to their crucial involvement in normal brain physiology, it is well known that astrocytes adopt a reactive phenotype under most acute and chronic pathological conditions such as ischemia, trauma, brain cancer, epilepsy, demyelinating and neurodegenerative diseases. However, the functional impact of astrocyte reactivity is still unclear. During the last decades, the development of innovative approaches to study astrocytes has significantly improved our understanding of their prominent role in brain function and their contribution to disease states. In particular, new genetic tools, molecular probes, and imaging techniques that achieve high spatial and temporal resolution have revealed new insight into astrocyte functions in situ. This Research Topic provides a collection of cutting-edge techniques, approaches and models to study astrocytes in health and disease. It also suggests new directions to achieve discoveries on these fascinating cells.
Astrocytes. --- Neurons --- Physiology. --- brain imaging --- transgenesis --- high-resolution imaging --- gene transfer --- Reactive astrocytes --- Electrophysiology --- neuron-astrocyte interactions --- In vivo analysis
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Enzymology --- Enzymes --- Asymmetry --- Biotechnology --- Clinical medicine --- Concentrations --- Enzymes, immobilized --- Immobilized cells --- In vivo analysis --- Membranes --- Metabolic pathways --- Multienzyme systems --- Reaction kinetics
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SPORULATION --- ANTIMETABOLITES --- ACTINOMYCIN --- DEHYDROGENASES --- HISTOCHEMISTRY --- AUTORADIOGRAPHY --- SUCROSE --- IN VIVO ANALYSIS --- IN VITRO ANALYSIS --- GIBBERELLINS --- GROWTH REGULATORS --- PLANT HORMONES --- CARBON DIOXIDE CYCLE --- CHLOROPLASTS --- NUCLEIC ACIDS --- BUDS --- PROTEIN METABOLISM --- METABOLIC INHIBITORS --- FLOWERING --- PLANT METABOLISM --- MITOSIS --- MERISTEMS --- APICAL DOMINANCE --- VERNALISATION --- CHLOROPHYLLS --- METABOLISM --- NUCLEIC ACIDS --- SPORULATION --- ANTIMETABOLITES --- ACTINOMYCIN --- DEHYDROGENASES --- HISTOCHEMISTRY --- AUTORADIOGRAPHY --- SUCROSE --- IN VIVO ANALYSIS --- IN VITRO ANALYSIS --- GIBBERELLINS --- GROWTH REGULATORS --- PLANT HORMONES --- CARBON DIOXIDE CYCLE --- CHLOROPLASTS --- NUCLEIC ACIDS --- BUDS --- PROTEIN METABOLISM --- METABOLIC INHIBITORS --- FLOWERING --- PLANT METABOLISM --- MITOSIS --- MERISTEMS --- APICAL DOMINANCE --- VERNALISATION --- CHLOROPHYLLS --- METABOLISM --- NUCLEIC ACIDS
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This Special Issue provides an update on the state of the art and current trends in polymeric drug-delivery systems specifically designed for improving drug bioavailability. The multiple contributions received further strengthen the role of polymers in modern drug delivery and targeting, illustrating the different approaches possible and unveiling what the future may bring.
Medicine --- Pharmaceutical industries --- cystic fibrosis --- Pseudomonas aeruginosa --- liposomes --- efflux pump inhibitor --- PABN --- aminoglycosides --- macrolides --- poloxamer --- thiourea --- thiolation --- mucoadhesion --- drug release --- in vivo analysis --- in vitro dissolution studies --- S-propargyl-cysteine --- poly(lactic acid) --- endogenous hydrogen sulfide --- water-in-oil-in-water --- rheumatoid arthritis --- chitosan --- drug delivery --- drug absorption --- intestinal assimilation --- oral bioavailability --- nanoemulsions --- micelles --- SEDDS --- zeta potential --- sustained release --- albumin nanoparticle --- MPT0B291 --- high-pressure homogenizer --- histone deacetylase --- calix[8]arenes --- silibinin --- inclusion complexes --- PEGylation --- cytotoxicity --- oromucosal films --- sodium alginate --- nanoparticle drug carriers --- digoxin --- zein --- heart failure --- polymer–liposome complexes --- Pluronic®-poly(acrylic acid) --- Pluronic®-poly(N,N-dimethylaminoethyl methacrylate) --- stimuli-responsive --- intelligent drug delivery systems --- liposome --- polymer --- long circulation --- polymer–lipid conjugates --- targeting --- stimulus-responsive --- antibody --- affinity --- cyclodextrin --- protein therapeutics --- sustained drug delivery --- Nitric oxide --- hydrogel --- wound dressing --- chronic wounds --- glycyrrhetinic acid --- Soluplus® --- solid dispersions --- anti-inflammatory --- biosafety --- bioavailability --- n/a --- polymer-liposome complexes --- polymer-lipid conjugates
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The Special Issue of Separations, “Development of Alternative Green Sample Preparation Techniques”, provides an overview on recent trends in green sample preparation. This Special Issue of Separations collates 11 impressive contributions that describe the state-of-the-art in the development of green extraction technologies, from green materials for microextraction to the development of new sampling devices geometries for enhanced extraction efficiency and analysis throughput.
Research & information: general --- Gac --- seeds --- Momordica cochinchinensis --- extraction --- trypsin inhibitors --- optimisation --- freeze drying --- response surface methodology --- metal-organic frameworks --- analytical chemistry --- sorbent materials --- stationary phases --- sensors --- sample preparation --- green considerations --- biosorbents --- microextraction --- organic compounds --- green extraction phases --- TF-SPME --- thermal desorption --- environmental analysis --- flavor and fragrance --- onsite sampling --- in vivo analysis --- ultra-trace analysis --- bar adsorptive microextraction --- floating sampling technology --- high-performance liquid chromatography --- polar UV filters --- real matrices --- foodomics --- Brazilian yeast --- craft beer --- sensomics --- automation --- sample handling --- chemical warfare agent --- SPE --- LLE --- non-invasive sampling --- wearable devices --- extractive patches --- skin sampling --- passive sampling --- green sampling technologies --- microextraction techniques --- body fluids --- bioactive compounds --- clinical and forensic analysis --- metal extraction --- liquid–liquid extraction --- solid-phase extraction --- solid-phase microextraction --- green extraction methods --- SPME --- green chemistry --- air sampling --- complex matrices --- mass spectrometry --- n/a --- liquid-liquid extraction
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The Special Issue of Separations, “Development of Alternative Green Sample Preparation Techniques”, provides an overview on recent trends in green sample preparation. This Special Issue of Separations collates 11 impressive contributions that describe the state-of-the-art in the development of green extraction technologies, from green materials for microextraction to the development of new sampling devices geometries for enhanced extraction efficiency and analysis throughput.
Gac --- seeds --- Momordica cochinchinensis --- extraction --- trypsin inhibitors --- optimisation --- freeze drying --- response surface methodology --- metal-organic frameworks --- analytical chemistry --- sorbent materials --- stationary phases --- sensors --- sample preparation --- green considerations --- biosorbents --- microextraction --- organic compounds --- green extraction phases --- TF-SPME --- thermal desorption --- environmental analysis --- flavor and fragrance --- onsite sampling --- in vivo analysis --- ultra-trace analysis --- bar adsorptive microextraction --- floating sampling technology --- high-performance liquid chromatography --- polar UV filters --- real matrices --- foodomics --- Brazilian yeast --- craft beer --- sensomics --- automation --- sample handling --- chemical warfare agent --- SPE --- LLE --- non-invasive sampling --- wearable devices --- extractive patches --- skin sampling --- passive sampling --- green sampling technologies --- microextraction techniques --- body fluids --- bioactive compounds --- clinical and forensic analysis --- metal extraction --- liquid–liquid extraction --- solid-phase extraction --- solid-phase microextraction --- green extraction methods --- SPME --- green chemistry --- air sampling --- complex matrices --- mass spectrometry --- n/a --- liquid-liquid extraction
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The Special Issue of Separations, “Development of Alternative Green Sample Preparation Techniques”, provides an overview on recent trends in green sample preparation. This Special Issue of Separations collates 11 impressive contributions that describe the state-of-the-art in the development of green extraction technologies, from green materials for microextraction to the development of new sampling devices geometries for enhanced extraction efficiency and analysis throughput.
Research & information: general --- Gac --- seeds --- Momordica cochinchinensis --- extraction --- trypsin inhibitors --- optimisation --- freeze drying --- response surface methodology --- metal-organic frameworks --- analytical chemistry --- sorbent materials --- stationary phases --- sensors --- sample preparation --- green considerations --- biosorbents --- microextraction --- organic compounds --- green extraction phases --- TF-SPME --- thermal desorption --- environmental analysis --- flavor and fragrance --- onsite sampling --- in vivo analysis --- ultra-trace analysis --- bar adsorptive microextraction --- floating sampling technology --- high-performance liquid chromatography --- polar UV filters --- real matrices --- foodomics --- Brazilian yeast --- craft beer --- sensomics --- automation --- sample handling --- chemical warfare agent --- SPE --- LLE --- non-invasive sampling --- wearable devices --- extractive patches --- skin sampling --- passive sampling --- green sampling technologies --- microextraction techniques --- body fluids --- bioactive compounds --- clinical and forensic analysis --- metal extraction --- liquid-liquid extraction --- solid-phase extraction --- solid-phase microextraction --- green extraction methods --- SPME --- green chemistry --- air sampling --- complex matrices --- mass spectrometry --- Gac --- seeds --- Momordica cochinchinensis --- extraction --- trypsin inhibitors --- optimisation --- freeze drying --- response surface methodology --- metal-organic frameworks --- analytical chemistry --- sorbent materials --- stationary phases --- sensors --- sample preparation --- green considerations --- biosorbents --- microextraction --- organic compounds --- green extraction phases --- TF-SPME --- thermal desorption --- environmental analysis --- flavor and fragrance --- onsite sampling --- in vivo analysis --- ultra-trace analysis --- bar adsorptive microextraction --- floating sampling technology --- high-performance liquid chromatography --- polar UV filters --- real matrices --- foodomics --- Brazilian yeast --- craft beer --- sensomics --- automation --- sample handling --- chemical warfare agent --- SPE --- LLE --- non-invasive sampling --- wearable devices --- extractive patches --- skin sampling --- passive sampling --- green sampling technologies --- microextraction techniques --- body fluids --- bioactive compounds --- clinical and forensic analysis --- metal extraction --- liquid-liquid extraction --- solid-phase extraction --- solid-phase microextraction --- green extraction methods --- SPME --- green chemistry --- air sampling --- complex matrices --- mass spectrometry
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