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Human embryo --- Miscarriage. --- Reproduction --- Transplantation. --- Immunological aspects. --- Immunoreproduction --- Abortion, Spontaneous --- Spontaneous abortion --- Fetal death --- Human embryo implantation --- Human embryo transfer --- Implantation of human embryo --- Embryo transplantation --- Human reproductive technology
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Recurrent Miscarriages (RM) & Implantation Failure (IF) have remained an enigma to clinicians and researchers. Even after ruling out all possible causative factors, 50-60% cases still remain “Unexplained’. A majority of these so called “Unexplained” cases are now found to have immunological basis. This book is going into the Immunological aspects of these clinical dilemmas, demystifying the role of Immunology and Immunotherapy in RM and IF. The authors have been working in the field of Reproductive Immunology and Immunotherapy for the last 25 years and they have come out with this book combining the international studies with their own experience. The purpose of writing this book is to provide a comprehensive treatise about Immunotherapy, so that it can become an acceptable modality of treatment in cases where it is needed and is effective. The book discusses the basics in Reproductive Immunology. The immunological changes occurring during pregnancy, the role of Cell mediated Immunity (T cells), Humoral Immunity including cytokines is explained. The normal immunological mechanisms protecting the embryo are highlighted and how these mechanisms are disturbed leading to RM and IF, is also explained. The first and the most discussed method of Immunotherapy is Lymphocyte Immunization Therapy (LIT). The book has given a complete overview of LIT, describing how it created euphoria when it was first introduced, how it gradually went into disrepute and how it is now making a comeback. As the authors have personal experience of LIT, the book gives a detailed and complete information about this active form of immunotherapy. The book has a special section on case studies where the authors have given some clinical case reports (including some of their own), who were treated for immunological factor in RM/IF and were treated with Immunotherapy. These cases can be a useful guide to the readers. The book will be useful not only for undergraduate and postgraduate students but also for clinicians in their practice and for researchers for review of developments in the field.
Human embryo --- Miscarriage. --- Reproduction --- Transplantation. --- Immunological aspects. --- Immunoreproduction --- Abortion, Spontaneous --- Spontaneous abortion --- Fetal death --- Human embryo implantation --- Human embryo transfer --- Implantation of human embryo --- Embryo transplantation --- Human reproductive technology --- Immunology. --- Medicine --- Biology --- Gynecology. --- Human physiology. --- Biomedical Research. --- Human Physiology. --- Research. --- Human biology --- Medical sciences --- Physiology --- Human body --- Gynaecology --- Generative organs, Female --- Biological research --- Biomedical research --- Health Workforce --- Immunobiology --- Life sciences --- Serology --- Diseases --- Ginecologia. --- Immunologia
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This concise work on embryo transfer is yet another contribution to the persevering effort to disseminate latest information on the science and skill of performing a traumatic and successful embryo transfer. It is the most critical culmination of the assisted reproductive technology (ART) stimulation cycle, and a rate-limiting step in dictating the success of treatment. The well-worded chapters draw the reader’s attention to significant aspects before initiating the actual embryo transfer, such as possible causes of failure at the embryo transfer stage, uterine evaluation, mock embryo transfer (ET), experience of the physician, and the use of ultrasound-guidance to monitor ET. The protocol for difficult transfers, variables that affect the success of ET, and the influence of the catheter used for ET have also been dealt with. The unique feature of this book is its pragmatic approach that can translate into solutions to the numerous frustrating ART failures that more often than not, may be attributed to an inefficient ET procedure. It helps the reader understand the integrity of embryo transfer, unravel its obvious simplicity and bridge the success between the several steps of ART. By highlighting the impeding problems associated with ET procedure and providing valid, scientific solutions, this stimulating edition will help the readers improve the ART success rates in their clinical practice. .
Medicine & Public Health. --- Reproductive Medicine. --- Gynecology. --- Obstetrics/Perinatology. --- Medicine. --- Obstetrics. --- Médecine --- Gynécologie --- Obstétrique --- Human embryo -- Transplantation. --- Medicine --- Health & Biological Sciences --- Gynecology & Obstetrics --- Human embryo --- Transplantation. --- Human embryo implantation --- Human embryo transfer --- Implantation of human embryo --- Reproductive medicine. --- Embryo transplantation --- Human reproductive technology --- Obstetrics/Perinatology/Midwifery. --- Maternal-fetal medicine --- Gynaecology --- Generative organs, Female --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Diseases --- Health aspects --- Gynecology .
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The versatility of oocyte and embryo donation has proven to be extremely valuable to both patients and doctors engaged in reproductive medicine. Originally thought to be applicable only to a rather small subset of infertile women, today busy practices commonly recommend the procedure and it is estimated that nearly all of the 400 or more IVF programs in the United States provide these services. Oocyte and embryo donation has established itself as a mainstay procedure within assisted reproductive care, and the breadth, depth and complexity of practice is deserving of focused attention. Much has changed within the field of oocyte and embryo donation since the publication of the first edition of Principles of Oocyte and Embryo Donation in 1998, thus the need for a completely updated and more expansive text. The second edition of this book provides an overview of the major issues affecting men and women engaged in the practice of oocyte and embryo donation. A primary emphasis has been placed on defining the standards of practice that have evolved over the past 30 years, clearly stating the outcomes expected from adhering to these established protocols. Details of both the basic science and the clinical medicine are presented together and attention is also focused on the non-reproductive aspects inherent to this unique method of assisted reproduction that involves opinions from lawyers, ethicists, mental health care professionals and theologians. Oocyte and embryo donation requires a working knowledge of the medicine, the law and the ethics that underlies its foundation. This book is intended to serve as a complete and comprehensive reference for all health care professionals that provide services related to egg donation, reproductive endocrinologists, obstetrician- gynecologists, and fellows and residents entering the fertility field.
Embryo transfer. --- Human embryo -- Transplantation. --- Oocyte donation. --- Ovum -- Transplantation. --- Medicine --- Health & Biological Sciences --- Gynecology & Obstetrics --- Human embryo --- Ovum --- Transplantation. --- Egg (Cytology) --- Egg cell --- Female gamete --- Oocyte --- Ovocyte --- Secondary oocyte --- Human embryo implantation --- Human embryo transfer --- Implantation of human embryo --- Medicine. --- Gynecology. --- Obstetrics. --- Endocrinology. --- Reproductive medicine. --- Medicine & Public Health. --- Reproductive Medicine. --- Obstetrics/Perinatology. --- Gametes --- Embryo transplantation --- Human reproductive technology --- Obstetrics/Perinatology/Midwifery. --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Maternal-fetal medicine --- Gynaecology --- Generative organs, Female --- Internal medicine --- Hormones --- Health aspects --- Diseases --- Endocrinology . --- Gynecology .
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This unique text discusses the wide range of causes and pathophysiologic conditions contributing to recurrent implantation failure (RIF) and the current treatment approaches to best approach this challenging patient population. Beginning with a presentation of the mechanism of normal implantation, the physiologic synchrony between embryo and endometrium, and the roles of both gametes and embryos in RIF, the book then examines the various genetic, immune and environmental factors involved. Abnormalities of the hematologic and endocrine system, as well as those of the anatomy and microbiome, are described in detail. Last but no less important, the psychological stress and treatment of patients experiencing RIF is discussed. Assisted reproductive technology (ART) success has increased substantially over the past three decades. However, despite these advances, recurrent implantation failure is still a common issue confronting patients and clinicians, and RIF represents one of the greatest challenges in ART and remains a source of frustration and disappointment for patients, clinicians, and researchers involved in the process. Providing an in-depth investigation into the pathophysiology and biological mechanisms of RIF and its clinical management, this will be an excellent resource for reproductive endocrinologists and infertility specialists. .
Human embryo --- Infertility, Female. --- Human reproductive technology. --- Transplantation. --- Medicine. --- Endocrinology. --- Reproductive medicine. --- Medicine & Public Health. --- Reproductive Medicine. --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Internal medicine --- Hormones --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health aspects --- Assisted human reproduction --- Assisted conception --- Conception --- Human assisted reproduction --- Medical technology --- Reproductive technology --- Female infertility --- Female sterility --- Sterility, Female --- Generative organs, Female --- Infertility --- Sterilization of women --- Human embryo implantation --- Human embryo transfer --- Implantation of human embryo --- Embryo transplantation --- Human reproductive technology --- Technological innovations --- Diseases --- Endocrinology .
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At last, a comprehensive collection of essays that examines and advances ethical evaluations of the controversial and increasingly popular practice of embryo adoption. In the United States alone, 400,000 frozen embryos created for in vitro fertilization exist but are no longer desired for that purpose. What are we morally obliged or permitted to do about these "spare" embryos? More of their genetic parents are considering donating these embryos to others to gestate and raise. This practice is politically volatile (figuring in debates about embryonic stem cells) and medically and morally complex. At the present time within the Roman Catholic Church there is no official teaching on embryo adoption. Catholic ethical analyses grapple with the way embryo adoption comports with respect for embryonic human life yet challenges Catholic moral critiques of assisted reproductive technologies. This volume brings together leading philosophers and theologians to engage Catholic debates about embryo adoption in an interactive format. The editors, a philosopher bioethicist and a moral theologian, provide a helpful overview of the practice and the arguments surrounding embryo adoption. They engage neglected Catholic ethical resources and issues to advance the current debate and chart new directions in Catholic moral thinking about this intriguing practice. The volume also includes a description of embryo adoption from a physician practitioner along with reflections from a couple who successfully adopted an embryo.
Human embryo --- Human reproductive technology --- Adoption --- Assisted human reproduction --- Assisted conception --- Conception --- Human assisted reproduction --- Human reproduction --- Human embryo implantation --- Human embryo transfer --- Implantation of human embryo --- Transplantation. --- Ethics. --- Religious aspects. --- Technological innovations --- Medicine. --- Religion. --- Religion --- Gynecology. --- Reproductive medicine. --- Medical ethics. --- Medicine & Public Health. --- Philosophy of Religion. --- Theory of Medicine/Bioethics. --- Reproductive Medicine. --- Religious Studies, general. --- Philosophy. --- Medical technology --- Reproductive technology --- Embryo transplantation --- Gynaecology --- Medicine --- Generative organs, Female --- Religion, Primitive --- Atheism --- God --- Irreligion --- Religions --- Theology --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Biomedical ethics --- Clinical ethics --- Ethics, Medical --- Health care ethics --- Medical care --- Bioethics --- Professional ethics --- Nursing ethics --- Social medicine --- Mental philosophy --- Humanities --- Deontology --- Ethics, Primitive --- Ethology --- Moral philosophy --- Morality --- Morals --- Philosophy, Moral --- Science, Moral --- Philosophy --- Values --- Diseases --- Health aspects --- Moral and ethical aspects --- Gynecology . --- Religion—Philosophy.
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Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.
Life Sciences. --- Embryology. --- Reproductive Medicine. --- Cytogenetics. --- Life sciences. --- Human genetics. --- Sciences de la vie --- Génétique humaine --- Embryologie --- Human embryo -- Transplantation. --- Human reproduction -- Immunological aspects. --- Spermatozoa -- Motility -- Disorders. --- Biology --- Health & Biological Sciences --- Biophysics --- Spermatozoa --- Human embryo --- Human reproduction --- Motility --- Disorders. --- Transplantation. --- Immunological aspects. --- Reproductive immunology --- Human embryo implantation --- Human embryo transfer --- Implantation of human embryo --- Motility disorders, Spermatozoal --- Spermatozoal motility disorders --- Reproductive medicine. --- Animal embryology --- Animals --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Embryos --- Reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Cytology --- Genetics --- Biosciences --- Sciences, Life --- Science --- Embryology --- Development --- Health aspects --- Embryo transplantation --- Human reproductive technology --- Infertility, Male --- Heredity, Human --- Human biology --- Physical anthropology --- Semen --- Embryo Implantation --- Aneuploidy. --- Infertility, Male. --- immunology. --- abnormalities. --- Aneuploid --- Aneuploid Cell --- Aneuploid Cells --- Aneuploidies --- Aneuploids --- Cell, Aneuploid --- Cells, Aneuploid --- Aneugens --- Sub-Fertility, Male --- Subfertility, Male --- Sterility, Male --- Male Infertility --- Male Sterility --- Male Sub-Fertility --- Male Subfertility --- Sub Fertility, Male --- Sperm Injections, Intracytoplasmic
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Human reproductive technology --- Reproductive technology --- Human chromosome abnormalities --- Embryo Transfer --- Fertilization in Vitro --- Genetics --- Reproductive Techniques --- Fecondation in vitro --- Embryon humain --- Procreation medicalement assistee --- Diagnostics preimplantatoires --- Diagnosis --- Transplantation --- Procréation médicalement assistée --- Fécondation in vitro --- Diagnostics préimplantatoires --- Human reproductive technology. --- Reproductive technology. --- Reproductive Techniques. --- Genetic Techniques. --- Diagnosis. --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- Reproduction Technics --- Reproduction Techniques --- Reproductive Technologies --- Technology, Reproductive --- Reproductive Technology --- Reproduction Technic --- Reproduction Technique --- Reproductive Technique --- Technic, Reproduction --- Technics, Reproduction --- Technique, Reproduction --- Technique, Reproductive --- Techniques, Reproduction --- Techniques, Reproductive --- Technologies, Reproductive --- Assisted reproduction --- Reproduction --- Assisted human reproduction --- Assisted conception --- Conception --- Human assisted reproduction --- Human reproduction --- Genetic diagnosis --- Genetic testing --- Human chromosomes --- methods --- Technological innovations --- Abnormalities --- Genetic Techniques --- Fertilizations in Vitro --- In Vitro Fertilization --- Test-Tube Babies --- Test-Tube Fertilization --- Babies, Test-Tube --- Baby, Test-Tube --- Fertilization, Test-Tube --- Fertilizations, Test-Tube --- In Vitro Fertilizations --- Test Tube Babies --- Test Tube Fertilization --- Test-Tube Baby --- Test-Tube Fertilizations --- Tubal Embryo Stage Transfer --- Blastocyst Transfer --- Tubal Embryo Transfer --- Embryo Transfers --- Transfer, Embryo --- Transfers, Embryo --- Blastocyst --- Embryo, Mammalian --- transplantation --- Selective Breeding --- Reproductive Medicine --- Reproductive Health Services --- Ectogenesis --- Genetic Engineering --- Insemination, Artificial --- Genetic Structures --- Genetic Phenomena --- Biotechnology --- Medical technology --- Chromosome abnormalities --- Genetic disorders --- Genetic Counseling --- Procréation médicalement assistée --- Fécondation in vitro --- Diagnostics préimplantatoires --- Infertility. --- Embryo Transfer. --- Fertilization in Vitro. --- Genetics. --- Reproduction Techniques. --- Reproductive Sterility --- Sterility, Reproductive --- Sub-Fertility --- Subfertility --- Sterility --- Fertility --- ART (Assisted reproductive technology) --- Assisted reproductive technology --- Reproductive techniques --- Assisted human reproductive technology --- Human assisted reproductive technology --- Human embryo --- Preimplantation genetic diagnosis --- Embryo transplantation. --- Chromosomes humains --- Embryons --- Fécondation in vitro. --- Génétique --- Technique. --- Innovations --- Anomalies --- Diagnostic --- Transplantation. --- Innovations. --- Embryo transfer --- Transfer of embryo --- Transplantation of organs, tissues, etc. --- Preembryo diagnosis --- Preimplantation diagnosis --- Prenatal diagnosis --- Embryo, Human --- Embryology, Human --- Preimplantation genetic diagnosis. --- Human embryo implantation --- Human embryo transfer --- Implantation of human embryo --- Embryo transplantation
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