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This fully updated volume utilizes the expertise of scientists currently engaged in immunotoxicity testing to provide the reader with lab-ready procedures and the background information needed to identify effective testing approaches. Dedicated to identifying and describing exogenous agents that can modify immune function, uncovering modes and mechanisms of action for such agents, and translating data from the laboratory and from the clinic to better predict health risks as well as benefits to those who are exposed to immunomodulatory agents, immunotoxicity testing continues to be a vital field of study, and this collection highlights both the “tried and true” methods as well as alternative protocols that have been more recently developed. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immunotoxicity Testing: Methods and Protocols, Second Edition serves as a valuable contribution to the continued evolution and the application of immunotoxicity testing.

Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Immunotoxicologia --- Manuals de laboratori --- Protocols clínics --- Immunotoxicitat --- Toxicologia immunològica --- Immunopatologia --- Toxicologia --- Immunofarmacologia --- Plans d'actuació mèdica --- Protocols en medicina --- Protocols de diagnòstic clínic --- Protocols mèdics --- Protocols terapèutics --- Medicina clínica --- Històries clíniques --- Protocols d'infermeria --- Tècniques de laboratori

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Immunotoxicology --- Poisons --- Environmental health --- Immunology --- Chemistry --- Health Sciences --- Life Sciences --- Toxicology --- Chemicals --- Poisonous chemicals --- Poisonous substances --- Toxic chemicals --- Toxic substances --- Toxicants --- Toxics --- Immunologic toxicology --- Immunotoxicity --- immunology --- toxicology --- immunotoxicology --- environmental toxicology --- Environmental health. --- Immunotoxicology. --- Bioactive compounds --- Hazardous substances --- Immunopathology --- Immunopharmacology --- Environmental quality --- Health ecology --- Health --- Public health --- Environmental engineering --- Health risk assessment --- Health aspects --- Environmental aspects --- Allergy --- farmacologie --- toxicologie --- allergieën --- Allergy and Immunology. --- Immunity --- Toxicology. --- Environmental Exposure --- physiology. --- adverse effects. --- immunology. --- Evidence Based Toxicology --- Evidence-Based Toxicology --- Toxinology --- Based Toxicologies, Evidence --- Based Toxicology, Evidence --- Evidence Based Toxicologies --- Evidence-Based Toxicologies --- Toxicologies, Evidence Based --- Toxicologies, Evidence-Based --- Toxicology, Evidence Based --- Toxicology, Evidence-Based --- Pharmacogenetics --- Allergy Specialty --- Allergy, Immunology --- Immunology and Allergy --- Immunology, Allergy --- Specialty, Allergy --- Immunotoxicologia --- Higiene ambiental --- Toxicologia industrial --- Immunotoxicologia. --- Higiene ambiental. --- Toxicologia industrial. --- Immunotoxicologie --- Toxicologie. --- Immunologie --- toxicology.

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This volume explores techniques that are currently used to understand solid target-specific models in computational toxicology. The chapters are divided into four sections and discuss topics such as molecular descriptors, QSAR and read-across; molecular and data modeling techniques to comply both with scientific and regulatory sides; computational toxicology in drug discovery; and strategies on how to predict various human-health toxicology endpoints. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the methods and software tools used, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Computational Toxicology: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this expanding field.

Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Toxicologia --- Models matemàtics --- Models (Matemàtica) --- Models experimentals --- Models teòrics --- Mètodes de simulació --- Anàlisi de sistemes --- Mètode de Montecarlo --- Modelització multiescala --- Models economètrics --- Models lineals (Estadística) --- Models multinivell (Estadística) --- Models no lineals (Estadística) --- Programació (Ordinadors) --- Simulació per ordinador --- Teoria de màquines --- Models biològics --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins

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This book explores well-established and emerging conjugation strategies that are relevant for proteins used in the field of precision medicine, focusing on techniques that are suitable for antibodies, antibody-fragments such as Fabs, scFvs, or nanobodies, scaffold proteins such as FN3 or DARPin, peptides, or model proteins. Although centered on the development of bioconjugates rather than their application, most protocols also show the conjugation of the targeting vehicle to a diagnostic or therapeutic entity, with the end-product most often being an antibody-drug conjugate, an optical probe, a nanomedicine, or a radiopharmaceutical. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Bioconjugation: Methods and Protocols is an ideal guide for researchers looking toward precision medicine in order to expand the vital field of drug discovery.

Monoclonal antibodies. --- Biochemistry. --- Toxicology. --- Antibodies. --- Protein Science. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning --- Toxicology --- Composition --- Anticossos monoclonals --- Toxicologia --- Manuals de laboratori --- Tècniques de laboratori --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins --- Immunoglobulines monoclonals --- Clonatge molecular --- Immunoglobulines --- Rituximab

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Apoptosis, or programmed cell death, is a widespread cellular process that regulates numerous important biological events ranging from the metamorphosis of the tadpole tail to the elimination of surplus brain cells in the formation of proper synaptic connections. In Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification, Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful in toxicology and pharmacology research. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high-throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems. Presented by authors well-versed in the technical problems and challenges in analyzing apoptosis, each method explicates its successful use, describes its limitations, and shows how it may be applied in large-scale screening operations. Concise and eminently practical, Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification offers pharmacologists, toxicologists, pathologists, and many other biomedical scientists today's gold standard reference source for methods that definitively identify and accurately quantify apoptosis.

Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Apoptosi --- Farmacologia --- Toxicologia --- Manuals de laboratori --- Tècniques de laboratori --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Fotofarmacologia --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Medicaments --- Quimioteràpia --- Mort cel·lular