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Immunosuppressive agents. --- Immunosuppressant agents --- Immunosuppressants --- Immunosuppressive drugs --- Drugs --- Immunopharmacology

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Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients wi

Immunosuppressive agents. --- Immunosuppression. --- Transplantation immunology. --- Transplantation of organs, tissues, etc. --- Cellular immunity --- Immunology --- Histocompatibility --- Immunological tolerance --- Depression, Immune --- Immune depression --- Immune suppression --- Immunodepression --- Suppression, Immune --- Immune response --- Therapeutics --- Immunodeficiency --- Immunosuppressant agents --- Immunosuppressants --- Immunosuppressive drugs --- Drugs --- Immunopharmacology --- Immunological aspects --- Regulation

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Immunosuppressive Agents. --- Pharmacology. --- Pharmacologies --- Pharmaceutical Preparations --- Immunosuppressants --- Immunosuppressant --- Immunosuppressive Agent --- Agent, Immunosuppressive --- Agents, Immunosuppressive --- Antirheumatic Agents --- pharmacology --- Immunosuppression. --- Immunosuppressive agents. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Immunosuppressant agents --- Immunosuppressive drugs --- Immunopharmacology --- Depression, Immune --- Immune depression --- Immune suppression --- Immunodepression --- Suppression, Immune --- Immune response --- Immunological tolerance --- Therapeutics --- Immunodeficiency --- Physiological effect --- Regulation

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This book collects salient observational data, derived predominantly from human studies, regarding the mechanism(s) of rejection in various pathologic conditions; the premise is that immune rejection, better defined as “immune-mediated, tissue-specific destruction” (TSD), comprises a broad range of phenomena ranging from tumor regression, to clearance of pathogen through destruction of infected cells, autoimmunity, allograft rejection by the host and host versus graft reactions. Like different hands can turn on or off a switch, distinct mechanisms can trigger TSD; however, a convergent pathway is ultimately observed when TSD occurs consisting of a dramatic switch from chronic to acute inflammation leading to the activation of a restricted number of genes that we comprise in the immunologic constant of rejection (ICR) model. Although the ICR model does not address “why” rejection occurs but rather “how”, and it may not contribute an explanation for the determinism of rejection, it provides, if correct, a simplified road map about the convergent pathways leading to TSD. This offers the opportunity to identify a common target for immune manipulation with therapeutic purposes since ICR-related pathways are restricted in expression to the tissues in which TSD occurs while are shut off in the rest of a normal organism. The book includes chapters from outstanding basic and/or observational scientists that have contributed to this area either by defining mechanisms relevant to the understanding of the inflammatory switch or by describing how this occurs in human tissues under different pathological conditions. We would like to entice our reader(s) to test with us, through, the readings, whether our hypothesis is correct; we predict that common themes will emerge particularly if attention will be paid to the general phenomenon of TSD rather than the peculiarities of individual pathologies. With the hope of having contributed with this book something novel and important and we wish our reader a pleasant journey in the wondrous land of immune-mediated, tissue-specific destruction.

Immunology --- Immunosuppressive agents --- Neoplastic Processes --- Immune System Diseases --- Host vs Graft Reaction --- Hypersensitivity --- Remission, Spontaneous --- Models, Biological --- Transplantation Immunology --- Neoplasms --- Diseases --- Models, Theoretical --- Pathologic Processes --- Biological Processes --- Neoplasm Regression, Spontaneous --- Autoimmune Diseases --- Hypersensitivity, Delayed --- Graft Rejection --- Models, Immunological --- Investigative Techniques --- Immune System Processes --- Biological Phenomena --- Pathological Conditions, Signs and Symptoms --- Phenomena and Processes --- Immune System Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Medicine --- Biology --- Health & Biological Sciences --- Oncology --- Microbiology & Immunology --- Immunology. --- Immunosuppressive agents. --- Immunosuppressant agents --- Immunosuppressants --- Immunosuppressive drugs --- Immunobiology --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Drugs --- Immunopharmacology --- Life sciences --- Serology --- Oncology. --- Tumors --- Cancer research

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This book covers the most recent research trends and applications of Pharmaceutical Analytical Chemistry. The included topics range from the adulteration of dietary supplements, to the determination of drugs in biological samples with the aim to investigate their pharmacokinetic properties.

Research & information: general --- growth hormone --- long-acting Fc-fusion recombinant human growth hormone --- method validation --- cell-based bioassay --- reporter gene assay --- pharmacokinetics --- tissue distribution --- alnustone --- rats --- LC-MS/MS --- inflammatory bowel disease --- fixed-dose combination --- biomimetic chromatography --- thiopurine immunosuppressants --- folic acid --- doxorubicin --- hernandezine --- pharmacokinetic study --- drug-drug interaction --- gardneramine --- monoterpenoid indole alkaloid --- memantine --- rimantadine --- amantadine --- zone fluidics --- o-phthalaldehyde --- derivatization --- stopped-flow --- quality control --- anwuligan --- rat --- optode --- polyhexamethylene biguanide hydrochloride --- lactone-rhodamine B --- contact-lens detergent --- dietary supplement --- adulteration --- low-field NMR --- multivariate analysis --- steroids --- Partial Least Squares regression --- in vitro permeability --- predictive model --- ketamine --- norketamine --- high throughput bar adsorptive microextraction --- LVI-GC-MS(SIM) --- urine --- baricitinib --- UPLC-MS/MS --- irbersartan --- growth hormone --- long-acting Fc-fusion recombinant human growth hormone --- method validation --- cell-based bioassay --- reporter gene assay --- pharmacokinetics --- tissue distribution --- alnustone --- rats --- LC-MS/MS --- inflammatory bowel disease --- fixed-dose combination --- biomimetic chromatography --- thiopurine immunosuppressants --- folic acid --- doxorubicin --- hernandezine --- pharmacokinetic study --- drug-drug interaction --- gardneramine --- monoterpenoid indole alkaloid --- memantine --- rimantadine --- amantadine --- zone fluidics --- o-phthalaldehyde --- derivatization --- stopped-flow --- quality control --- anwuligan --- rat --- optode --- polyhexamethylene biguanide hydrochloride --- lactone-rhodamine B --- contact-lens detergent --- dietary supplement --- adulteration --- low-field NMR --- multivariate analysis --- steroids --- Partial Least Squares regression --- in vitro permeability --- predictive model --- ketamine --- norketamine --- high throughput bar adsorptive microextraction --- LVI-GC-MS(SIM) --- urine --- baricitinib --- UPLC-MS/MS --- irbersartan