Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Rapamycin. --- Immunosuppressive agents. --- Immunosuppressant agents --- Immunosuppressants --- Immunosuppressive drugs --- Drugs --- Immunopharmacology --- Sirolimus --- Immunosuppressive agents --- Macrolide antibiotics

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Reperfusion injury --- Ischemia. --- Immunosuppressive agents. --- Pathophysiology. --- Myocardial Reperfusion Injury --- Fingolimod Hydrochloride --- Myocardial Ischemia. --- physiopathology. --- therapeutic use. --- Heart Disease, Ischemic --- Ischemia, Myocardial --- Ischemic Heart Disease --- Disease, Ischemic Heart --- Diseases, Ischemic Heart --- Heart Diseases, Ischemic --- Ischemias, Myocardial --- Ischemic Heart Diseases --- Myocardial Ischemias --- Immunosuppressant agents --- Immunosuppressants --- Immunosuppressive drugs --- Drugs --- Immunopharmacology --- Ischaemia --- Blood circulation disorders --- Injury, Reperfusion --- Ischemia --- Coronary heart disease. --- Immunosuppressive Agents.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book collects salient observational data, derived predominantly from human studies, regarding the mechanism(s) of rejection in various pathologic conditions; the premise is that immune rejection, better defined as “immune-mediated, tissue-specific destruction” (TSD), comprises a broad range of phenomena ranging from tumor regression, to clearance of pathogen through destruction of infected cells, autoimmunity, allograft rejection by the host and host versus graft reactions. Like different hands can turn on or off a switch, distinct mechanisms can trigger TSD; however, a convergent pathway is ultimately observed when TSD occurs consisting of a dramatic switch from chronic to acute inflammation leading to the activation of a restricted number of genes that we comprise in the immunologic constant of rejection (ICR) model. Although the ICR model does not address “why” rejection occurs but rather “how”, and it may not contribute an explanation for the determinism of rejection, it provides, if correct, a simplified road map about the convergent pathways leading to TSD. This offers the opportunity to identify a common target for immune manipulation with therapeutic purposes since ICR-related pathways are restricted in expression to the tissues in which TSD occurs while are shut off in the rest of a normal organism. The book includes chapters from outstanding basic and/or observational scientists that have contributed to this area either by defining mechanisms relevant to the understanding of the inflammatory switch or by describing how this occurs in human tissues under different pathological conditions. We would like to entice our reader(s) to test with us, through, the readings, whether our hypothesis is correct; we predict that common themes will emerge particularly if attention will be paid to the general phenomenon of TSD rather than the peculiarities of individual pathologies. With the hope of having contributed with this book something novel and important and we wish our reader a pleasant journey in the wondrous land of immune-mediated, tissue-specific destruction.

Immunology --- Immunosuppressive agents --- Neoplastic Processes --- Immune System Diseases --- Host vs Graft Reaction --- Hypersensitivity --- Remission, Spontaneous --- Models, Biological --- Transplantation Immunology --- Neoplasms --- Diseases --- Models, Theoretical --- Pathologic Processes --- Biological Processes --- Neoplasm Regression, Spontaneous --- Autoimmune Diseases --- Hypersensitivity, Delayed --- Graft Rejection --- Models, Immunological --- Investigative Techniques --- Immune System Processes --- Biological Phenomena --- Pathological Conditions, Signs and Symptoms --- Phenomena and Processes --- Immune System Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Medicine --- Biology --- Health & Biological Sciences --- Oncology --- Microbiology & Immunology --- Immunology. --- Immunosuppressive agents. --- Immunosuppressant agents --- Immunosuppressants --- Immunosuppressive drugs --- Immunobiology --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Drugs --- Immunopharmacology --- Life sciences --- Serology --- Oncology. --- Tumors --- Cancer research

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book covers the most recent research trends and applications of Pharmaceutical Analytical Chemistry. The included topics range from the adulteration of dietary supplements, to the determination of drugs in biological samples with the aim to investigate their pharmacokinetic properties.

Research & information: general --- growth hormone --- long-acting Fc-fusion recombinant human growth hormone --- method validation --- cell-based bioassay --- reporter gene assay --- pharmacokinetics --- tissue distribution --- alnustone --- rats --- LC-MS/MS --- inflammatory bowel disease --- fixed-dose combination --- biomimetic chromatography --- thiopurine immunosuppressants --- folic acid --- doxorubicin --- hernandezine --- pharmacokinetic study --- drug-drug interaction --- gardneramine --- monoterpenoid indole alkaloid --- memantine --- rimantadine --- amantadine --- zone fluidics --- o-phthalaldehyde --- derivatization --- stopped-flow --- quality control --- anwuligan --- rat --- optode --- polyhexamethylene biguanide hydrochloride --- lactone-rhodamine B --- contact-lens detergent --- dietary supplement --- adulteration --- low-field NMR --- multivariate analysis --- steroids --- Partial Least Squares regression --- in vitro permeability --- predictive model --- ketamine --- norketamine --- high throughput bar adsorptive microextraction --- LVI-GC-MS(SIM) --- urine --- baricitinib --- UPLC-MS/MS --- irbersartan

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The current application of antibody-meditated targeted therapy against cancer has resulted in significant objective clinical responses, prolongation of survival and even cures. More than 20 mAbs have been approved for human use targeting a range of different cancers. However, a major drawback of mAb therapeutics is that a subset of patients does not initially respond and another initially responding subset develops resistance to further treatments. At the present time, there are no effective therapies for these subsets of cancer patients. The analyses of underlying mechanisms responsible for resistance are necessary to develop and generate new targeted therapies that overcome the resistance. Resistance to Immunotherapeutic Antibodies in Cancer: Strategies to Overcome Resistance is a timely volume that deals with various mechanisms of resistance to anti-cancer mAbs therapeutics as well as it deals with novel approaches to overcome resistance. The reviews in this volume are written by highly qualified, established and experienced leaders in the field of resistance to anti-cancer mAbs.

Cancer -- Treatment. --- Immunomodulation --- Drug Resistance --- Diseases --- Pharmacological Phenomena --- Biological Therapy --- Therapeutics --- Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Phenomena and Processes --- Neoplasms --- Drug Resistance, Neoplasm --- Immunosuppression --- Immunotherapy --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Drug resistance in cancer cells. --- Monoclonal antibodies. --- Immunosuppressive agents. --- Immunotherapy. --- Immunosuppressant agents --- Immunosuppressants --- Immunosuppressive drugs --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Antitumor drug resistance --- Cancer drug resistance --- Drug resistance in cancer --- Drug resistance in tumor cells --- Medicine. --- Cancer research. --- Immunology. --- Antibodies. --- Molecular biology. --- Biomedicine. --- Cancer Research. --- Molecular Medicine. --- Drugs --- Immunopharmacology --- Immunoglobulins --- Molecular cloning --- Cancer cells --- Immunological aspects --- Treatment --- Oncology. --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Tumors --- Health Workforce --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research