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Recent major advances in our understanding of basic immunology have led to the development of powerful new adjuvants-substances that can stimulate the innate immune system and significantly improve the effectiveness of antigen-based vaccines. In Vaccine Adjuvants: Immunological and Clinical Principles, highly respected clinical immunologists and vaccine researchers detail the major research areas in this new era of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses. Among the highlights are an explanation of innate immune signaling-including Toll-like receptors-in vaccination, and a preview of emerging technologies in adjuvant research, such as microparticles and novel lipid and carbohydrate adjuvants. Authoritative and eminently practical, Vaccine Adjuvants: Immunological and Clinical Principles moves from the basic principles of the innate immune system, through the characteristics of specific adjuvants, to detailed methods for developing the safer and more effective adjuvants that will trigger these powerful immune responses, and finally to the combinations of immune responses needed for successful vaccination.

Immunological adjuvants. --- Vaccines. --- Biologicals --- Adjuvants (Immunology) --- Adjuvants, Immunologic --- Adjuvants, Immunological --- Immune adjuvants --- Immunoactivators --- Immunoadjuvants --- Immunologic adjuvants --- Immunomodulators --- Immunopotentiators --- Immunostimulants --- Biological response modifiers --- Adjuvants, Immunologic. --- Vaccines --- immunology.

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Tumors --- Immunological adjuvants --- Adjuvants, Immunologic --- Immunosuppression --- Neoplasms --- Immunological aspects --- Congresses --- immunology --- Tumours --- Pathology --- Cysts (Pathology) --- Oncology --- Adjuvants (Immunology) --- Adjuvants, Immunological --- Immune adjuvants --- Immunoactivators --- Immunoadjuvants --- Immunologic adjuvants --- Immunomodulators --- Immunopotentiators --- Immunostimulants --- Biological response modifiers --- Immunological aspects&delete&

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Eimeria --- Immunological adjuvants --- Avian coccidiosis --- Eimeria. --- Immunological adjuvants. --- Treatment --- Adjuvants, Immunologic --- Adjuvants, Immunological --- Adjuvants (Immunology) --- Immune adjuvants --- Immunoactivators --- Immunoadjuvants --- Immunologic adjuvants --- Immunomodulators --- Immunopotentiators --- Immunostimulants --- Biological response modifiers --- Eimeriidae --- Coccidiosis in poultry --- Coccidiosis in animals --- Poultry --- Diseases

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This book provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations.* Contributions from leading international authorities in the field* Well-illustrated, informative figures present the interactions between immunopotentiators and

Vaccines. --- Biologicals --- Immunological adjuvants. --- Immune response --- Immune modulation --- Immunity --- Immunomodulation --- Immunoregulation --- Regulation of immunity --- Regulation of the immune response --- Idiotypic networks --- Biological response modifiers --- Ir genes --- Adjuvants (Immunology) --- Adjuvants, Immunologic --- Adjuvants, Immunological --- Immune adjuvants --- Immunoactivators --- Immunoadjuvants --- Immunologic adjuvants --- Immunomodulators --- Immunopotentiators --- Immunostimulants --- Regulation. --- Regulation

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Immunomodulation in Domestic Food Animals

Immune response --- Regulation --- Adjuvants [Immunological ] --- Physiological effect --- Immunotherapy --- Animal food --- Composition --- Immunological adjuvants --- Veterinary immunology. --- Domestic animals --- Livestock --- Clinical immunology --- Immunologic diseases in animals --- Adjuvants (Immunology) --- Adjuvants, Immunologic --- Adjuvants, Immunological --- Immune adjuvants --- Immunoactivators --- Immunoadjuvants --- Immunologic adjuvants --- Immunomodulators --- Immunopotentiators --- Immunostimulants --- Biological response modifiers --- Therapeutic use. --- Immunology