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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Immunology --- immunological memory --- B cell memory --- T cell memory --- vaccination --- adjuvant --- infection

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The ability to remember an antigenic encounter for several decades, even for a life time, is one of the fundamental properties of the immune system. This phenomenon known as "immunological memory", is the foundation upon which the concept if vaccination rests. Therefore, understanding the mechanisms by which immunological memory is regulated is of paramount importance. Recent advances in immunology, particularly in the field of innate immunity, suggest that the innate immune system plays fundamental roles in influencing immunological memory. Indeed, emerging evidence suggests that events that occur early, within hours if not minutes of pathogen or vaccine entry profoundly shape the quantity, quality and duration of immunological memory. The present volume assembles a collection of essays from leading experts that span the entire spectrum research from understanding the molecular mechanisms of innate immune recognition, to dendritic cell function, to the generation and maintenance of antigen-specific B and T-cell responses.

Immunologic memory. --- Natural immunity. --- Immune response. --- Immunology --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Immunity --- Immune memory --- Immunological memory --- Memory, Immune --- Memory, Immunologic --- Immunology. --- Immunobiology --- Life sciences --- Serology

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Immunological memory has fascinated microbiologists and immunologists for decades as one of the new frontiers to conquer to better understand the response to pathogens, cancer and vaccination. Over the past decade, attention has turned to the intrinsic properties of the memory T cells themselves, as it has become clear that the eradication of both infected cells and tumors requires T cells. This book is an attempt to capture the wave of discoveries associated with these recent studies. Its chapters represent a wide collection of topics related to memory T cells by laboratories that have invested their skills and knowledge to understand the biology and the principles upon which memory T cells are generated, maintained and expanded upon re-encounter with antigen. Ultimately, these studies are all aimed at a better understanding of the function of memory T cells in protection against disease.

Immunologic memory. --- T cells. --- Immunologic memory --- T cells --- Lymphocytes --- Adaptive Immunity --- Immunity --- Leukocytes, Mononuclear --- Immune System Phenomena --- Leukocytes --- Phenomena and Processes --- Blood Cells --- Immune System --- Blood --- Cells --- Hemic and Immune Systems --- T-Lymphocytes --- Autoimmunity --- Immunologic Memory --- Immunity, Cellular --- Anatomy --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Biophysics --- T lymphocytes --- Thymus-dependent cells --- Thymus-dependent lymphocytes --- Thymus-derived cells --- Immune memory --- Immunological memory --- Memory, Immune --- Memory, Immunologic --- Medicine. --- Human physiology. --- Molecular biology. --- Neurochemistry. --- Neurology. --- Biomedicine. --- Human Physiology. --- Molecular Medicine. --- Medicine --- Nervous system --- Neuropsychiatry --- Biochemistry --- Neurosciences --- Molecular biochemistry --- Molecular biophysics --- Biomolecules --- Systems biology --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Diseases --- Health Workforce --- Neurology .