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Primary Immunodeficiency Disorders: A Historic and Scientific Perspective provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can miss important points about a disease, or miss out on how to approach new diseases. This historical knowledge of research can assist greatly by showing how it was done in the past, demonstrating the successes and failures, so that it can be done better in the future. This book provides an understanding of the process going from clinical problem to lab and back to the clinic, based on historical experiences. Its chapters proceed from the discovery of the T and B cell lineages through the first BMT for immunodeficiency disorder; lab investigation and gene therapy for PID; the discovery of the gene for AT and its function; understanding cytokine defects; and many other stops along the way. Facilitates communication among physicians and other investigators concerned with immunological and inflammatory diseases Summarizes for the first time all the known facts from 60 years of primary immunodeficiency research, and teaches how an important field in medicine was established Provides stimulating discussions on developing new medical therapies Highlights the importance of studying humans to understand mechanisms of disease that affect humans.

Autoimmune diseases. --- Immunological deficiency syndromes. --- Immune deficiency syndromes --- Immunodeficiency syndromes --- Immunologic deficiency syndromes --- Immunodeficiency --- Immunologic diseases --- Syndromes --- Autoimmunologic diseases --- Autoimmunity

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Immunologic diseases. --- Immunodeficiency. --- Immunological deficiency syndromes. --- Immune System Diseases. --- Immune deficiency syndromes --- Immunodeficiency syndromes --- Immunologic deficiency syndromes --- Immunodeficiency --- Immunologic diseases --- Syndromes

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Immunology. Immunopathology --- Sociology of health --- Infectious diseases. Communicable diseases --- Klinische psychologie --- AIDS (Disease) --- specifieke problemen --- specifieke problemen. --- Immunological deficiency syndromes. --- Specifieke problemen. --- Immune deficiency syndromes --- Immunodeficiency syndromes --- Immunologic deficiency syndromes --- Immunodeficiency --- Immunologic diseases --- Syndromes --- United States --- AIDS (Disease) - United States.

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Over the past twenty-five years, the number of patients with compromised immune systems has grown astronomically. High-risk patients such as these require a unique set of healthcare solutions that take into consideration everything from the etiology and degree of immune suppression to the individual patient's nutritional status. This comprehensive volume examines a wide range of approaches and challenges to infectious disease diagnostics for immunocompromised patients.

Diagnostic microbiology --- Immunological deficiency syndromes --- Opportunistic infections. --- Infection --- Immune deficiency syndromes --- Immunodeficiency syndromes --- Immunologic deficiency syndromes --- Immunodeficiency --- Immunologic diseases --- Syndromes --- Clinical microbiology --- Microbiology, Clinical --- Microbiology, Diagnostic --- Diagnosis, Laboratory --- Medical microbiology --- Communicable diseases --- Pathogenic microorganisms --- Serology --- Technique. --- Diagnosis. --- Diagnosis --- Infections. --- Bacterial Infections. --- Immunocompromised Host. --- Microbiological Techniques. --- Mycoses. --- Virus Diseases. --- Microbiologie clinique --- Syndromes de déficit immunitaire --- Infections opportunistes --- Technique --- Diagnostic

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World Health Organization data documents that infectious diseases and immunodeficiencies are the leading causes of morbidity and mortality in the world's children. In The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes, an authoritative, international panel of experts provide a succinct, up-to-date, evidence-based reference to the neurological consequences of infectious diseases and immunodeficiency syndromes in children in one readily accessible volume. Within each of its conveniently structured chapters, readers will find a general description of the disease or disorder, its epidemiology, etiology, clinical synopsis, neurological manifestations, diagnosis, differential diagnosis and therapy. Comprehensive yet concise, The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes is an ideal guide for pediatricians, primary care physicians and subspecialists to the complex relationships between infectious diseases, immunodeficiency syndromes and the neurological process.

Communicable diseases in children. --- Neurologic manifestations of general diseases. --- Immunological deficiency syndromes. --- Immune deficiency syndromes --- Immunodeficiency syndromes --- Immunologic deficiency syndromes --- Immunodeficiency --- Immunologic diseases --- Syndromes --- Neurologic symptoms of general diseases --- Neurological manifestations of general diseases --- Nervous system --- Symptoms --- Children --- Infection in children --- Diseases --- Pediatrics. --- Neurology. --- Emerging infectious diseases. --- Immunology. --- Infectious Diseases. --- Immunobiology --- Life sciences --- Serology --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Medicine --- Neuropsychiatry --- Paediatrics --- Pediatric medicine --- Health and hygiene --- Neurology . --- Infectious diseases.