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Hypertension, Renovascular --- Family Practice

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Le maintien du volume et de la composition des liquides du milieu intérieur nécessite une action intégrée du système rénine-angiotensine-aldostérone (RAS), du système nerveux sympathique, de l’hormone antidiurétique (ADH) et du facteur natriurétique auriculaire (ANF). A côté de ces fonctions neuro-humorales, l’endothélium vasculaire joue aussi un rôle important (Donckier et al. 1992). Un endothélium normal est beaucoup plus qu’une barrière passive. C’est un tissu actif, réagissant à des nombreux signaux humoraux, hormonaux ou physiques. L’endothélium sécrète un nombre de substances avec des effets opposés : des facteurs vasodilatateurs (endothélium-derived-relaxing-factor ou EDRF ; prostaglandine-I2 ou PGI2) et des facteurs constricteurs (thromboxane-A2 ; endothéline-1 ou ET-1 ; angiotensine-II ou AG-II).
Il existe des interactions entre les facteurs vasodilatateurs et vasoconstricteurs ce qui donne à l’endothélium la capacité de répondre de manière intégrée aux changements de son environnement. L’endothélium contribue ainsi à l’homéostase cardio-vasculaire par l’ajustement du calibre des vaisseaux sanguins.
Un déséquilibre entre les facteurs vasodilatateurs et vasoconstricteurs contribuent à plusieurs maladies cardiovasculaires : athérosclérose, problèmes de réperfusion, insuffisance cardiaque, hypertension,…(Rubanyi, 1993).
Dans ce mémoire, 2 facteurs vasoconstricteurs sont étudiés dans un modèle d’hypertension réno-vasculaire : l’angiotensine-II et l’endothéline-1.

Endothelin-1 --- Angiotensin-2 --- Hypertension Renovascular --- Dogs --- Medical Laboratory Science

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Kidney Diseases --- Vascular Diseases --- Diagnostic Imaging --- Renal Artery --- Hypertension, Renovascular --- methods

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Angiotensin-Converting Enzyme Inhibitors --- Hypertension, Renovascular --- Kidney --- Radioisotope Renography --- pharmacokinetics --- physiopathology --- physiology --- methods

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Arrhythmia --- Heart surgery --- HEART DEFECTS, CONGENITAL --- HEART --- SURGERY --- RECTAL PROLAPSE --- RECTUM --- BACTERIAL INFECTIONS --- SPLEEN --- SPLENECTOMY --- ETIOLOGY --- INJURIES --- HYPOPHYSECTOMY --- PITUITARY GLAND --- NEOPLASMS --- OMENTUM --- CATHETERIZATION, CENTRAL VENOUS --- CATHETERIZATION, PERIPHERAL --- ADVERSE EFFECTS --- ABDOMEN --- SUTURE TECHNICS --- Diverticulosis, colonic --- Esophageal neoplasms --- BIOPSY, NEEDLE --- PATHOLOGY --- HYPERPARATHYROIDISM --- THYROID GLAND --- CROSS INFECTION --- DISINFECTION --- ENVIRONMENT, CONTROLLED --- PATIENT ISOLATORS --- STERILIZATION --- ULTRAVIOLET RAYS --- PREVENTION AND CONTROL --- METHODS --- THORACIC NEOPLASMS --- THORACIC SURGERY --- Esophageal and gastric varices --- Hemorrhage, gastrointestinal --- Hypertension, portal --- POSITIVE PRESSURE RESPIRATION --- RESPIRATION --- RESPIRATION, ARTIFICIAL --- ANUS --- COLON AND RECTAL SURGERY (SPECIALITY) --- ABNORMALITIES --- HISTORY --- Adrenal gland neoplasms --- Carcinoma --- Neoplasms, multiple endocrine --- AMPUTATION, TRAUMATIC --- ARM --- ARM INJURIES --- HAND --- HAND INJURIES --- REPLANTATION --- BLOOD TRANSFUSION, AUTOLOGOUS --- BILIARY TRACT --- CHOLESTASIS --- BILE DUCT NEOPLASMS --- CHOLANGIOMA --- COMPLICATIONS --- ANUS DISEASES --- RECTAL DISEASES --- THYROID NEOPLASMS --- LUNG --- TRACHEA --- HEART VALVES --- TRANSPLANTATION --- Nutrition --- Surgery, operative --- ABDOMINAL WALL --- GASTROINTESTINAL SYSTEM --- HERNIA, UMBILICAL --- Heart transplantation --- CARCINOMA --- SALIVARY GLANDS --- SALIVARY GLAND NEOPLASMS --- BLADDER NEOPLASMS --- Common bile duct calculi --- ANTIBIOTICS --- PREMEDICATION --- SURGERY, OPERATIVE --- THERAPEUTIC USE --- PEPTIC ULCER --- DRUG THERAPY --- ESOPHAGEAL STENOSIS --- ESOPHAGUS --- GASTROINTESTINAL HEMORRHAGE --- PELVIC NEOPLASMS --- PELVIS --- BILE DUCTS --- BILE DUCT DISEASES --- HEPATECTOMY --- LIVER --- TRENDS --- Diabetes Mellitus. --- LUNG NEOPLASMS --- Fibroma --- Neoplasms, multiple primary --- ABDOMINAL NEOPLASMS --- TOMOGRAPHY, X-RAY COMPUTED --- RADIOGRAPHY --- MEDIASTINAL CYST --- MEDIASTINAL NEOPLASMS --- MEDIASTINUM --- ADRENAL GLAND NEOPLASMS --- NEUROBLASTOMA --- PHEOCHROMOCYTOMA --- THERAPY --- BURNS --- VASCULAR DISEASES --- DIAGNOSIS --- Apudoma --- INTESTINAL ABSORPTION --- OBESITY --- STOMACH --- MUSCLE SPASTICITY --- UROGENITAL SYSTEM --- SPINAL CORD INJURIES --- SPINAL INJURIES --- PHYSIOPATHOLOGY --- IMMUNITY --- IMMUNITY, CELLULAR --- IMMUNOLOGY --- COLITIS, ULCERATIVE --- COLON --- CROHN DISEASE --- INTESTINAL DISEASES --- INTESTINES --- Stomach ulcer --- GASTROINTESTINAL HORMONES --- METABOLISM --- BLOOD VESSELS --- HEART INJURIES --- HEART SURGERY --- INTESTINAL POLYPS --- URINARY DIVERSION --- LYMPHOPROLIFERATIVE DISORDERS --- TRANSPLANTATION, HOMOLOGOUS --- ANESTHESIA --- ANESTHESIOLOGY --- ANESTHETICS --- CAROTID ARTERIES --- ENDARTERECTOMY --- BREAST --- MASTECTOMY --- PROSTHESIS --- SURGERY, PLASTIC --- DUODENAL ULCER --- DUODENUM --- LYMPHATIC METASTASIS --- LYMPHATIC SYSTEM --- NEOPLASM METASTASIS --- Hypertension, renovascular --- IN INFANCY AND CHILDHOOD --- BRONCHI --- ABDOMINAL INJURIES --- THORACIC INJURIES --- BILE DUCT OBSTRUCTION, EXTRAHEPATIC --- DRAINAGE --- INTUBATION --- Gastrostomy --- ANTINEOPLASTIC AGENTS --- ARTERIAL OCCLUSIVE DISEASES --- BLOOD SUPPLY --- PANCREAS --- ENDOSCOPY --- GASTROINTESTINAL DISEASES --- LIVER NEOPLASMS --- DIABETES MELLITUS --- FOOT DISEASES