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Psychiatry --- Human genetics --- Chorée de Huntington --- Huntington's chorea --- Huntington's disease --- Huntingtons chorea --- Maladie de Huntington --- Ziekte van Huntington --- Mental illness --- Genetic aspects

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Huntington's chorea. --- Brain --- Brain diseases --- Psychology, Pathological --- Chronic progressive chorea --- Chronic progressive hereditary chorea --- Degenerative chorea --- HC (Disease) --- HD (Disease) --- Hereditary chorea --- Huntington chorea --- Huntington chronic progressive hereditary chorea --- Huntington disease --- Huntington's chorea --- Lund-Huntington chorea --- Microcellular striatal syndrome --- Progressive hereditary chorea, Chronic --- Chorea --- Dementia --- Genetic disorders --- Nervous system --- Diseases. --- Degeneration --- Huntington's disease.

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It is now almost a decade since the identification of the Huntington's Disease gene and its mutation, during which time, major advances in our understanding of this disorder have been achieved. Since publication of the first two editions of this book, there have been considerable insights into how the mutation leads to the molecular pathology, neuropathology and clinical symptoms of Huntington's Disease, and experimental tools are now in place to take this research further towards new therapeutic approaches. As a result of these major advances, this well-established series of books has required radical updating. An international group of researchers and clinicians with specialist interests in HD has been commissioned to document the recent advances in our understanding of this disease. Developments in the fields of structural biology, cell biology, neurochemistry and neuropathology, with full coverage of transgenic animal models, are discussed in detail. The clinical sections cover genetic, neurological and psychiatric aspects as well as new developments in therapy.; This book will continue to provide an invaluable source of information for clinicians and scientists involved with Huntington's Disease, including geneticists, psychiatrists and neurologists, and basic science research workers in genetics and neurobiology.

Huntington's disease --- Huntington Disease. --- Medicine --- Health & Biological Sciences --- Neurology --- Akinetic-Rigid Variant of Huntington Disease --- Chorea, Chronic Progressive Hereditary (Huntington) --- Chronic Progressive Hereditary Chorea (Huntington) --- Huntington Chronic Progressive Hereditary Chorea --- Huntington Disease, Akinetic-Rigid Variant --- Huntington Disease, Juvenile --- Huntington Disease, Juvenile-Onset --- Huntington Disease, Late Onset --- Huntington's Chorea --- Huntington's Disease --- Juvenile-Onset Huntington Disease --- Late-Onset Huntington Disease --- Progressive Chorea, Chronic Hereditary (Huntington) --- Progressive Chorea, Hereditary, Chronic (Huntington) --- Huntington Chorea --- Juvenile Huntington Disease --- Akinetic Rigid Variant of Huntington Disease --- Chorea, Huntington --- Chorea, Huntington's --- Huntington Disease, Akinetic Rigid Variant --- Huntington Disease, Juvenile Onset --- Huntington Disease, Late-Onset --- Juvenile Onset Huntington Disease --- Late Onset Huntington Disease --- Chronic progressive chorea --- Chronic progressive hereditary chorea --- Degenerative chorea --- HC (Disease) --- HD (Disease) --- Hereditary chorea --- Huntington chorea --- Huntington chronic progressive hereditary chorea --- Huntington disease --- Huntington's chorea --- Lund-Huntington chorea --- Microcellular striatal syndrome --- Progressive hereditary chorea, Chronic --- Chorea --- Dementia --- Genetic disorders --- Nervous system --- Degeneration --- Huntington's chorea.

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Huntington's disease is a progressive neurodegenerative disorder of the brain. It is one of the quite devastating and currently incurable human conditions. Degeneration of specific types of neurons in the brain results in a triad of clinical features: serious behavioral disturbances, uncontrolled movements of body parts, and deterioration of intellectual capabilities. The underlying complex mechanisms and molecular players of the cellular cascades still need to be deciphered in detail despite considerable advances. Once solved, the related molecular mechanisms will not only enlighten the HD story but will also shed light on other polyglutamine diseases and similar brain disorders. This book, Huntington's Disease-Molecular Pathogenesis and Current Models, is planned to cover recent scientific achievements in understanding the cellular mechanisms of HD. The chapters provide comprehensive description of the key issues in HD research. In this regard, this book will serve as a source for clinicians and researchers in the field and also for life science readers in increasing their understanding and awareness of the clinical correlates, genetic aspects, neuropathological findings, and potential therapeutic interventions related to HD.

Huntington's disease. --- Chronic progressive chorea --- Chronic progressive hereditary chorea --- Degenerative chorea --- HC (Disease) --- HD (Disease) --- Hereditary chorea --- Huntington chorea --- Huntington chronic progressive hereditary chorea --- Huntington disease --- Huntington's chorea --- Lund-Huntington chorea --- Microcellular striatal syndrome --- Progressive hereditary chorea, Chronic --- Chorea --- Dementia --- Genetic disorders --- Nervous system --- Degeneration --- Medicine --- Neurology --- Mental and Behavioural Disorders and Diseases of the Nervous System --- Health Sciences

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Huntington's disease is a genetically inherited condition which results in severe nerve-cell damage in the brain. The hereditary and debilitative nature of the disease means that many people are involved either directly or indirectly by this condition. The recent identification of the faulty gene involved has made the diagnosis of this condition simpler. The majority of people develop the disease between the ages of 35 and 55 years, so for those aware of their genetic risk there aredilemmas to consider - should you have a test to see if you have the gene? Should you start a family?The new edit

Huntington's chorea --- Chorea. --- Saint Vitus's dance --- St. Vitus's dance --- Extrapyramidal disorders --- Chronic progressive chorea --- Chronic progressive hereditary chorea --- Degenerative chorea --- HC (Disease) --- HD (Disease) --- Hereditary chorea --- Huntington chorea --- Huntington chronic progressive hereditary chorea --- Huntington disease --- Lund-Huntington chorea --- Microcellular striatal syndrome --- Progressive hereditary chorea, Chronic --- Chorea --- Dementia --- Genetic disorders --- Nervous system --- Degeneration --- Ziekte van Huntington --- Ziekten --- Ziekte