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Cognition. --- Emotion. --- Emotionality. --- House mice. --- Mice. --- Social.
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House mice. --- Mice. --- Preference. --- Space. --- Territories. --- Territory.
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1442
Function. --- House mice. --- Marking. --- Mice. --- Population. --- Urine.
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Aggression. --- Agonistic. --- Agression. --- Dominance. --- Female. --- House mice. --- Male. --- Males. --- Mice.
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The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consi
Mice --- Nervous system. --- House mice --- House mouse --- Mouse --- Mus musculus --- Rodents
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Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development. Provides high-resolution images for best visualization of key developmental processes and structures; Offers in-depth anatomy and morphological views of organ systems; Written descriptions convey developmental origins of the organ systems.
Mice --- House mice --- House mouse --- Mouse --- Mus musculus --- Rodents --- Embryology. --- Development. --- Physiology.
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Mice --- Anatomy. --- Morphology. --- House mice --- House mouse --- Mouse --- Mus musculus --- Rodents
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Details the diversity, evolution and ecology of Australia's native rodents.
Mice --- Rats --- Rat --- Muridae --- House mice --- House mouse --- Mouse --- Mus musculus --- Rodents
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The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular dissection of quantitative traits, embryo biotechnology, ENU mutagenesis, and
Mice --- Mice as laboratory animals. --- Laboratory animals --- House mice --- House mouse --- Mouse --- Mus musculus --- Rodents --- Genetics.
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Neuroplasticity in the brain is dynamically controlled in space and time. Different permissive factors and molecular brakes establish and eventually stabilize optimal functional networks in such a way that they are still capable to adapt in response to experience. The visual cortex has been a valuable research model to study neocortical development, function and plasticity from mice to men. For instance, partial loss of vision by monocular enucleation (ME) early in life and in adulthood has been linked to widespread structural and functional reorganization in the visual cortex after short- and long-term survival times. However, the deprivation effects in ages that represent adolescence and cortical changes along the full extent of the visual and non-visual cortices are often overlooked. In that regard we initiated this doctoral project to fulfill these shortcomings. In adult mice, complete reactivation of deprived visual cortex involves an early visually driven recovery followed by multimodal plasticity 3 to 7 weeks post-ME and had been discovered at the beginning of this investigation. We have specifically investigated the age dependence of the onset and the exact timing of both ME-induced reactivation processes by comparing cortical activity patterns of mice enucleated at postnatal day 45 (adolescence) or 120 (adult). Radioactive in situ hybridization for the activity reporter gene zif268 in the visual cortex of adolescent and adult ME mice revealed striking differences. A swifter open-eye potentiated reactivation, between 3 and 5 days, characterized the binocular visual cortex of adolescent mice yet even after 7 weeks, the reactivation remained incomplete, especially in the medial monocular cortex. Consequently, we wondered to what extent monocular enucleation in mice of intermediate age group would induce enucleation-enabled plasticity. In comparison to adolescence, emergent cross-modal participation was demonstrated in P90 animals, although robust reactivation similar to enucleated adults was not achieved yet. Concomitantly, 7 weeks post-ME, somatosensory and auditory cortex shifted from a hypoactive state in adolescence to hyperactivity in adulthood. Thus, we provide evidence for a pre-sensitive period in which gradual recruitment of cross-modal recovery upon long-term monocular enucleation coincides with the transition from adolescence to adulthood in mice. In other words, the cross-modal recruitment of visual cortex following late onset vision loss, at least for monocular enucleation, is stronger in adults.Since the cellular and molecular players that regulate co-occurrence of uni- and cross-modal plasticity specifically in adulthood remain largely elusive, a second aim of this thesis was to apply dark exposure, a housing strategy known to shift the cortical excitation-inhibition balance, as a tool to study the role of the GABAergic system in the age-dependent aspect of ME-induced plasticity. We examined if dark exposure has an impact on the visual cortex reactivation by placing mice in total darkness for 10 days prior to monocular enucleation. Intriguingly, dark exposure converted the outcome of monocular enucleation in adult mice into a more adolescent-like response. A permanent deficit in neuronal activity was detected, most likely reflecting the absence of the cross-modal facet of reactivation due to dark exposure. At the molecular level, monocular enucleation preferentially decreased vGAT levels and induced more GABA production via increased GAD65 and GAD67 levels in the medial monocular cortex. Yet these changes at the presynaptic site were independent of age or dark exposure. However, at the postsynaptic site, elevated levels of the GABAA receptor alpha 1 subunit (mediating phasic inhibition) but not the delta subunit (mediating tonic inhibition), specifically characterized incomplete reactivation like in dark exposed and adolescent mice. Together, our molecular observations put the level of intracortical phasic inhibition forward as an important permissive factor for the age- and experience-dependent cross-modal response to long-term monocular enucleation.To conclude, monocular enucleation as well as dark exposure in the mouse will definitely be outstanding animal models to further decipher the cellular and molecular basis for the age- and experience-dependent response of the visual cortex to deprivation or lesions. In addition, they can enrich our understanding of cross-modal interactions and plasticity, in the emerging context of a high incidence of multimodal neurons and areas in the rodent and higher-order mammalian neocortex, including human.
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