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Aging --- Hormesis. --- Epigenetics. --- Genetics --- Poisons --- Physiological aspects. --- Physiological effect

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While there is a tremendous literature on the topic of wine and health ranging back to the days of Hippocrates, it is considered that there is an unlimited variety of wine, allowing for the association of senses, nutrition, and hedonism. The history of vine and wine has lasted for at least 7000 years. Vitis represent adaptable plants, and thanks to the large variety of strains, wine is an alchemical mix with unique properties, a rich and original composition in terms of polyphenols, and well known antioxidants. This explains why wine and health are closely linked to nutrition.

polyphenols --- n/a --- red wine --- apigenin --- tyrosol --- neurotrophic effects --- neuronal differentiation --- Okinawa diet --- colorectal --- antioxidant capacity --- olive oil --- vine --- alcohol --- antioxidant --- electrochemical technology --- Mediterranean diet --- allergy --- cardiovascular protection --- N2a murine neuronal cells --- cancers --- dementia --- wine --- resveratrol derivatives --- RW --- substituents phenyl rings --- efficacy towards diseases --- grape pomace --- metabolic disease --- Alzheimer --- biological targets --- wine flavonoids --- metabolites characterization --- diet --- hydroxytyrosol --- hormesis --- resveratrol --- cardiovascular disease --- nrf2 --- health --- synthesis strategies --- EVOO --- cancer --- hypertension

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Dose-response relationship (Biochemistry) --- Drugs --- Dose-Response Relationship, Drug. --- Drug Therapy. --- Pharmacology. --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacology --- Pharmacy --- Dose-effect relationship (Biochemistry) --- Relationship, Dose-response (Biochemistry) --- Biochemistry --- Drug effects --- Pharmacodynamics --- Dose Response Relationship, Drug --- Dose-Response Relationships, Drug --- Drug Dose-Response Relationship --- Drug Dose-Response Relationships --- Relationship, Drug Dose-Response --- Relationships, Drug Dose-Response --- Dose-response relationship --- Physiological effect --- Dose-response relationship. --- Physiological effect. --- Dose-effect relationship --- Dosage --- Chemistry --- Health Sciences --- Life Sciences --- Toxicology --- Public health --- Pharmacology. Therapy --- farmacologie --- hormesis --- dose-response

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Nutritional deficiencies, and different nutritional and dietary lifestyles, whether poor or absent of essential nutrients, aside from excess intake, can lead to inflammatory complications and loss of function. Bioactive compounds are non-nutritional components derived from plants, foods, and beverages with a multitude of biological effects. The improvement of analytical techniques has allowed scientific community to state that the regular consumption of bioactive phytochemicals is related to the prevention of numerous pathologies, through mechanisms that involve oxidative stress reduction, gene expression modulation, and even enzymatic activation inhibition.

quercetin --- nervous system --- molecular signals --- pharmacological potential --- cognitive impairment. --- micronuclei --- radioprotectors --- radiation effects --- melanoma --- PNT2 --- B16F10 cells --- Ulmus parvifolia --- wound healing --- matrix metalloproteinase --- transforming growth factor --- skin rejuvenation --- kaempferol --- naringin --- orientin --- rutin --- vitexin --- chlorogenic acid --- citric acid --- malic acid --- quinic acid --- rosmarinic acid --- curcumin --- nanocurcumin --- neurological disorders --- nanocarriers --- liposomes --- cancer --- diet --- flavonoids --- food supplements --- hormesis --- phytoestrogens --- sulforaphane --- resveratrol --- cardiovascular disease --- nanomedicine --- liposome --- nanoformulation --- RNA-dependent RNA polymerase --- remdesivir --- chloroquine --- SARS-CoV-2 --- COVID-19 --- spike glycoproteins --- Acorus calamus --- ethnomedicinal --- phytochemistry --- toxicity --- pharmacological action --- clinical trial --- neuroprotective --- neurological --- metabolic application --- kurarinone --- coronavirus --- HCoV-OC43 --- autophagy --- infection --- MRC-5 cell --- LC3 --- p62/SQSTM1 protein --- n/a

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To celebrate its 10th anniversary, the prestigious journal Cells launched a series of Special Issues in 2021. The Special Issue entitled “10th Anniversary of Cells—Advances in Cell Cycle” was launched together with other sister Special Issues under the umbrella “10th Anniversary of Cells.” The cell cycle is a series of events that drives cells to divide and produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the following phases: G1, S, G2, and M phases. Cell cycle progression is mediated by cyclin-dependent kinases (CDKs) and their regulatory cyclin subunits. CDKs, such as CDK4/6, CDK2, and CDK1 (also known as CDC2), are serine/threonine kinases with a wide variety of substrates. CDKs are activated mainly by binding to their cyclin partners, whose expressions rise and fall throughout the cell cycle to mediate the temporal activation of each CDKs. Various cell cycle checkpoints exist to ensure that critical processes are engaged prior to progression to the next phase. These cell cycle checkpoints are the G1 (restriction) checkpoint, the G2/M DNA damage checkpoint, and the spindle assembly checkpoint (SAC).This Special Issue attracted the attention of many scientists in the cell cycle field and consists of 10 high quality papers, including four research articles and six scientific reviews: a great success. The four research articles focus on various important topics of the cell cycle using a broad range of model organisms, including yeast, sea urchins, green algae, and human cancer cell lines.

Research & information: general --- Biology, life sciences --- microalgae --- Desmodesmus quadricauda --- cell cycle --- starch --- lipids --- polyphosphate --- guanine --- confocal Raman microscopy --- prenatal life --- perinatal life --- 5-bromo-2′-deoxyuridine --- cerebellar neuroepithelium --- external granular layer --- neurogenetic timetables --- neurogenetic gradients --- apoptosis --- M2 muscarinic receptor --- glioblastoma --- aberrant mitosis --- mitotic spindle --- Leishmania spp. --- leishmaniases --- telomeres --- telomerase --- growth factors --- receptor tyrosine kinases --- G1 phase --- S phase --- G2 phase --- M phase --- Ras/Erk --- PI3K/Akt --- vitelline layer --- fertilization --- sea urchin eggs --- plasticity --- Ca2+ signaling --- actin --- DTT --- TCEP --- BPA-C8-Cy3 --- electron microscopy --- Nud1 --- Cdc15 --- MEN --- mitotic exit --- Dbf2 --- Mob1 --- spindle position checkpoint --- HSF1 --- HSF2 --- cell cycle arrest --- APC/C complex --- CDK --- CTD phosphatase --- RNA polymerase II --- CTD code --- transcription --- LDIR --- hormesis --- cancer --- p21Waf1(CDKN1A) --- n/a --- 5-bromo-2'-deoxyuridine