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"Hidradenitis suppurativa, or acne inversa, is a chronic inflammatory skin disorder clinically characterized by acne-like skin lesions, follicular occlusion and recurrent inflammation. The underlying cause of the disease is not clear, but effective treatment relies on resection of all involved skin and subcutaneous tissue. As such, Hidradenitis Suppurativa: From Diagnosis to Treatment details specific operative nuances of affected locations and surgical approaches to localized, regional, and more systemic disease. The surgical management of moderate to severe hidradenitis suppurativa affecting the axilla is explored in the context of the excision and reconstructive techniques available. In closing, the authors discuss evidence-based therapeutic approaches for the management and treatment of hidradenitis suppurativa and how, most commonly, a multimodal treatment plan is required for optimal response"--

Hidradenitis suppurativa.

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Dermatologie --- Huidziekten --- Acne Vulgaris. --- Acne --- Hidradenitis Suppurativa --- Theses --- Acne Vulgaris

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A concise but comprehensive pocket handbook that provides an accessible and up-to-date introductory overview of this debilitating skin disease. Written by highly recognizable leaders in the field, this book presents essential information on the pathophysiology, clinical presentation, diagnosis and management strategies and options for hidradenitis suppurativa, forming an ideal resource to increase awareness of this disease among healthcare professionals.

Medicine. --- Dermatology. --- Medicine & Public Health. --- Skin --- Diseases. --- Cutaneous diseases --- Dermatoses --- Dermatology --- Medicine --- Diseases --- Hidradenitis suppurativa. --- Acne inversa --- Hidradenitides, Suppurative --- Hidradenitis, Suppurative --- Suppurativa hidradenitis --- Suppurative hidradenitides --- Suppurative hidradenitis --- Bacterial diseases --- Sweat glands

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The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions.

Medicine --- Pharmaceutical industries --- COVID-19 --- drug repurposing --- topological data analysis --- persistent Betti function --- SARS-CoV-2 --- network-based pharmacology --- combination therapy --- nucleoside GS-441524 --- fluoxetine --- synergy --- antidepressant --- natural compounds --- QSAR --- molecular docking --- drug repositioning --- UK Biobank --- vaccine --- LC-2/ad cell line --- drug discovery --- docking --- MM-GBSA calculation --- molecular dynamics --- cytotoxicity assay --- GWAS --- multiple sclerosis --- oxidative stress --- repurposing --- ADME-Tox --- bioinformatics --- complex network analysis --- modularity clustering --- ATC code --- hidradenitis suppurativa --- acne inversa --- transcriptome --- proteome --- comorbid disorder --- biomarker --- signaling pathway --- druggable gene --- drug-repositioning --- MEK inhibitor --- MM/GBSA --- Glide docking --- MD simulation --- MM/PBSA --- single-cell RNA sequencing --- pulmonary fibrosis --- biological networks --- p38α MAPK --- allosteric inhibitors --- in silico screening --- computer-aided drug discovery --- network analysis --- psychiatric disorders --- medications --- psychiatry --- mental disorders --- toxoplasmosis --- Toxoplasma gondii --- in vitro screening --- drug targets --- drug-disease interaction --- target-disease interaction --- DPP4 inhibitors --- lipid rafts

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Sexuality is considered as a great human value related to happiness and satisfaction, but unfortunately, when affecting mental disorders, they tend to be associated with second level human functions. Nevertheless, sexual dysfunction often accompanies psychiatric disorder, intensely influencing compliance, quality of life and human relationships. Sexuality could be influenced either by a mental disorder itself, difficulties to get and maintain couple relationships or by the use of psychotropic treatments. Treatment-related adverse events are unfortunately under-recognized by clinicians, scarcely spontaneously communicated by patients, and rarely investigated in clinical trials. The most frequent psychotropic compounds that could deteriorate sexuality and quality of life include antidepressants, antipsychotics and mood regulators. There are important differences between them related to some variations in mechanisms of action including serotonin, dopamine and prolactin levels. Little is known about the relevance of sexuality and its dysfunctions in chronic and frequent mental and neurological disorders, such as psychosis, mood disorders, anxiety, phobias, eating disorders, alcohol or drug dependencies, epilepsy and childhood pathology. Poor sexual life, low satisfaction and more frequent risky sex behavior than in the general population are associated with severe mental diseases. There is a need for increasing research in this field, including epidemiological, psychological, neurophysiological, neuroanatomical and genetic variables related to sexual life to get a better understanding of the implicated mechanisms. To increase the sensibility of clinicians, the identification and management of sexual disturbances after the onset of any mental disorder should be highlighted. This would avoid unnecessary suffering and deterioration of quality of life.

Humanities --- Social interaction --- online pornography --- addiction --- cybersex --- internet --- compulsive sexual behavior --- hypersexuality --- dopaminergic system --- paroxetine --- agomelatine --- immunohistochemical study --- sexual dysfunction --- male rats --- sexual addiction --- sexual compulsivity --- phenomenology --- comorbidities --- opioid-related disorders --- methadone --- adverse effects --- erectile dysfunction --- medication adherence --- erotic stimulus processing --- serotonin --- noradrenaline --- dopamine --- fMRI --- healthy --- human --- sexual communication anxiety --- sexual perfectionism --- parent-child communication --- risky sexual behavior --- child sexual abuse --- female perpetrator --- mother-child incest --- gender stereotypes --- social taboo --- transgender --- anxiety --- depression --- social loneliness --- romantic loneliness --- autism --- sexual satisfaction --- Asperger syndrome --- sexual desire --- lubrication --- sexual intercourse --- sexual excitation --- sexual inhibition --- post-traumatic stress disorder --- veterans --- predictors --- sexuality --- mental health --- mental disorder --- hidradenitis suppurativa --- sexual abstinence --- partner status --- prison inmates --- eye tracking --- non-consensual image sharing --- intimate images --- objectification --- objectifying gaze --- rape myth acceptance --- sexting --- desvenlafaxine --- antidepressant --- treatment --- prsexdq-salsex questionnaire --- switching strategy --- female sexual dysfunction --- hormonal contraceptive --- libido --- desire --- sex life --- orgasm --- vaginal ring --- depot medroxyprogesterone acetate --- pornography --- delayed ejaculation --- NeMUP --- child sexual offending --- pedophilia --- SCID --- peyronie’s disease --- penile induration --- patient satisfaction --- research --- online pornography --- addiction --- cybersex --- internet --- compulsive sexual behavior --- hypersexuality --- dopaminergic system --- paroxetine --- agomelatine --- immunohistochemical study --- sexual dysfunction --- male rats --- sexual addiction --- sexual compulsivity --- phenomenology --- comorbidities --- opioid-related disorders --- methadone --- adverse effects --- erectile dysfunction --- medication adherence --- erotic stimulus processing --- serotonin --- noradrenaline --- dopamine --- fMRI --- healthy --- human --- sexual communication anxiety --- sexual perfectionism --- parent-child communication --- risky sexual behavior --- child sexual abuse --- female perpetrator --- mother-child incest --- gender stereotypes --- social taboo --- transgender --- anxiety --- depression --- social loneliness --- romantic loneliness --- autism --- sexual satisfaction --- Asperger syndrome --- sexual desire --- lubrication --- sexual intercourse --- sexual excitation --- sexual inhibition --- post-traumatic stress disorder --- veterans --- predictors --- sexuality --- mental health --- mental disorder --- hidradenitis suppurativa --- sexual abstinence --- partner status --- prison inmates --- eye tracking --- non-consensual image sharing --- intimate images --- objectification --- objectifying gaze --- rape myth acceptance --- sexting --- desvenlafaxine --- antidepressant --- treatment --- prsexdq-salsex questionnaire --- switching strategy --- female sexual dysfunction --- hormonal contraceptive --- libido --- desire --- sex life --- orgasm --- vaginal ring --- depot medroxyprogesterone acetate --- pornography --- delayed ejaculation --- NeMUP --- child sexual offending --- pedophilia --- SCID --- peyronie’s disease --- penile induration --- patient satisfaction --- research