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Xenotransplantation : comprehensive study
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ISBN: 1789856647 1789856639 Year: 2020 Publisher: London, United Kingdom : IntechOpen,

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Book
Xenotransplantation : scientific frontiers and public policy
Authors: --- --- ---
ISBN: 1573311871 1573311863 Year: 1998 Volume: 862


Book
Patient-Derived Mouse Models of Cancer : Patient-Derived Orthotopic Xenografts (PDOX)
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ISBN: 3319574248 331957423X Year: 2017 Publisher: Cham : Springer International Publishing : Imprint: Humana,

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This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems.


Book
Animal tissue into humans : a report by the advisory group on the ethics of xenotransplantation.
Authors: --- ---
ISBN: 0113218664 Year: 1996 Publisher: London Stationery office


Book
Clinical xenotransplantation : pathways and progress in the transplantation of organs and tissues between species
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ISBN: 3030491277 3030491269 Year: 2020 Publisher: Cham, Switzerland : Springer,

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This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.


Book
Xenotransplantation and risk : regulating a developing biotechnology
Author:
ISBN: 1107223474 1280484772 9786613579751 1139221817 1139216996 1139223526 113921392X 1139220098 1139026925 9781139223522 9781139026925 9780521195768 0521195764 9781139216999 9781107223479 9781280484773 6613579750 9781139221818 9781139220095 1139209108 Year: 2012 Publisher: Cambridge ; New York : Cambridge University Press,

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Some developing biotechnologies challenge accepted legal and ethical norms because of the risks they pose. Xenotransplantation (cross-species transplantation) may prolong life but may also harm the xeno-recipient and the public due to its potential to transmit infectious diseases. These trans-boundary diseases emphasise the global nature of advances in health care and highlight the difficulties of identifying, monitoring and regulating such risks and thereby protecting individual and public health. Xenotransplantation raises questions about how uncertainty and risk are understood and accepted, and exposes tensions between private benefit and public health. Where public health is at risk, a precautionary approach informed by the harm principle supports prioritising the latter, but the issues raised by genetically engineered solid organ xenotransplants have not, as yet, been sufficiently discussed. This must occur prior to their clinical introduction because of the necessary changes to accepted norms which are needed to appropriately safeguard individual and public health.

Your life or mine : how geoethics can resolve the conflict between public and private interests in xenotransplantation.
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ISBN: 0754623912 Year: 2004 Publisher: Aldershot Ashgate

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The issue of xenotransplantation is the subject of this monograph. The author demonstrates that problems regarding the introduction of zoonoses into the human gene pool can be overcome. The book also considers costs, and the perception by some that using animals to keep dying humans alive is inherently cruel.

Xenotransplantation : law and ethics.
Authors: ---
ISBN: 0754623793 9780754623793 Year: 2005 Publisher: Aldershot Ashgate

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Examines the legal and ethical issues surrounding xenotransplantation. This book points out that xenotransplantation, which represents a deviation from medical practice and the possibility of transplantation of large segments of tissue, or whole organs from animals into humans, poses a set of considerations necessary to evaluate and understand. One of the leading causes of death is organ failure, that is, when one or other of the organs that run the machine we call the body gives out. However, whereas with a machine, spare parts can usually replace faulty parts, in the case of humans the supply of these is limited as it is dependent on organs being obtained from living or dead donors. Due to the limitations of supply, increasing attention is being paid to alternative schemes for obtaining organs. One of these possibilities is xenotransplantation: using organs from animals. In this book, the authors examine the legal and ethical issues surrounding xenotransplantation and consider the implications for the future. As they point out, xenotransplantation represents a major deviation from standard medical practice and the possibility of transplantation of large segments of tissue, or whole organs, from animals into humans poses an entirely novel set of considerations - ethical, legal and scientific - which is necessary to evaluate and understand.


Periodical
Xenotransplantation.
Author:
ISSN: 13993089 0908665X Year: 1994 Publisher: [Oxford, England] : Hoboken, NJ : Danvers, MA : Blackwell Pub. Wiley-Blackwell John Wiley & Sons

Le brevet sur l'animal : xénotransplantation.
Authors: ---
ISBN: 2760511189 1435687027 2760522504 9782760511187 9781435687028 9782760522503 Year: 2001 Publisher: Sainte-Foy Presses de l'Université du Québec

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A une époque ou les progrès des biotechnologies connaissent une croissance fulgurante, les scientifiques préconisent une solution révolutionnaire au problème de la pénurie d'organes : la xénotransplantation, c'est-à-dire la transplantation d'organes animaux chez l'être humain. Cet ouvrage est consacré à l'analyse d'une question juridique qui en découle, soit le brevet sur l'animal qui s'inscrit dans le débat plus général du brevet sur le vivant. Cette question soulève de grands remous et provoque beaucoup d'appréhension, dans la mesure où le brevet fait craindre une " marchandisation " du vivant menant à celle de l'homme. Au Canada, la question n'est pas encore réglée. Après une dizaine d'années devant les tribunaux, elle se trouve actuellement entre les mains de la Cour suprême. L'impact de cette décision tant attendue pourrait être lourd de conséquences. Afin de circonscrire la problématique, l'auteur procède à une analyse comparative de l'état du droit canadien, européen et américain sur la question. Elle examine également les préoccupations éthiques inhérentes au débat, ainsi que les enjeux économiques qu'il soulève. A l'issue de son analyse, elle propose des solutions et des pistes de réflexion visant l'atteinte d'un équilibre. qui se révèle essentiel, entre ces divers enjeux.

Keywords

Transplantation of organs, tissues, etc. --- Xenografts --- Medical ethics. --- Law and legislation. --- Moral and ethical aspects. --- Law and legislation --- Government policy --- 342.721 --- 347.771 --- Medical ethics --- Transplantation of organs, tissues, etc --- -Xenografts --- -342.721 --- xenotransplantatie --- patent (octrooi, patentrecht, octrooirecht, biopatent) --- dieren --- Biomedical ethics --- Clinical ethics --- Ethics, Medical --- Health care ethics --- Medical care --- Medicine --- Bioethics --- Professional ethics --- Nursing ethics --- Social medicine --- 347.771 Octrooirecht. Brevet. Know-how --- Octrooirecht. Brevet. Know-how --- 342.721 Persoonlijke vrijheid. Privacy. Wetgeving i.v.m. transplantatie van organen --- Persoonlijke vrijheid. Privacy. Wetgeving i.v.m. transplantatie van organen --- Heterografts --- Heterologous transplants --- Heteroplastic grafts --- Xenotransplantation --- Medical transplantation --- Organ transplantation --- Organ transplants --- Organs (Anatomy) --- Surgical transplantation --- Tissue transplantation --- Tissues --- Transplants, Organ --- Surgery --- Preservation of organs, tissues, etc. --- Procurement of organs, tissues, etc. --- -Moral and ethical aspects --- xénotransplantation (xénogreffe) --- brevet (brevetabilité, brevetabilité biologique, droit de brevet, droit des brevets, brevetabilité du vivant) --- animaux --- Moral and ethical aspects --- Transplantation --- Medical laws and legislation --- Transplant surgery --- Transplantation surgery

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