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Chlorodibenzodioxins --- Dioxins --- Congresses --- Analysis --- Heterocyclic Compounds, 1-Ring --- Heterocyclic Compounds --- Chemicals and Drugs --- Chemistry --- Physical Sciences & Mathematics --- Chemistry - General --- Organic Chemistry --- Congresses. --- analysis --- Ecology. --- Herbicides --- Physical property --- Toxicity

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RNA Modification provides a useful examination of the science and its role in biological regulation, the current frontier of life science research, and includes various RNA modications and their role in gene expression. It represents the most up-to-date knowledge and protocols available today.

• Dynamic RNA modifications and their roles in biological regulation are the current frontier of life science research
• This volume of Methods in Enzymology represents up to date knowledge and protocols

RNA Processing, Post-Transcriptional --- Pseudouridine --- RNA, Transfer --- Gene Expression Regulation --- Uridine --- Biochemical Processes --- RNA --- Metabolism --- Genetic Processes --- Ribonucleosides --- Pyrimidine Nucleosides --- Biochemical Phenomena --- Chemical Processes --- Nucleic Acids --- Metabolic Phenomena --- Nucleosides --- Genetic Phenomena --- Nucleic Acids, Nucleotides, and Nucleosides --- Phenomena and Processes --- Chemical Phenomena --- Pyrimidines --- Chemicals and Drugs --- Heterocyclic Compounds, 1-Ring --- Heterocyclic Compounds --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- RNA editing. --- ARN --- pharmacokinetics --- Edition --- Editing, RNA --- Messenger RNA editing --- mRNA editing --- RNA Processing, Post-Transcriptional. --- pharmacokinetics. --- Genetic regulation

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th This volume contains articles presented at the X International Symposium on Purines and Pyrimidines in Man, held on May 14 19, 2000 in Tel Aviv, Israel. The first symposium in this series took place in Tel Aviv in 1973. Since then, the symposium has been held every three years in different parts of the world, including Europe, USA and Japan. The participants, in this series of symposia, are characterised by a wide interest in the various aspects of purines and pyrimidines in man, which include biochemistry, genetics, pharmacology, physiology, clinics, etc. Presentations in the symposia include clarification of metabolic pathways, characterisation of enzyme structure and kinetics and discoveries of new inborn errors of metabolism and suggestions for new therapeutic approaches for these inborn errors. In addition, development of new purine and pyrimidine derivatives for the treatment of cancer and viral diseases, and many more subjects of mutual interest were brought to the fore. With the development of therapeutic means and of new research tools, we have witnessed changes in the areas of interest. The interest in gout and uric acid urolithiasis has lessened, whereas molecular aspects, the role of purine and pyrimidine substances in neurotransmission and in purinergic signaling appear to gain greater interest. The articles, included in this volume, contain new data pertaining to the various aspects detailed above.

Electronic books. -- local. --- Purines -- Metabolism -- Congresses. --- Purines -- Metabolism -- Disorders -- Congresses. --- Pyrimidines -- Metabolism -- Congresses. --- Pyrimidines -- Metabolism -- Disorders -- Congresses. --- Purines --- Pyrimidines --- Metabolism, Inborn Errors --- Publication Formats --- Metabolic Phenomena --- Heterocyclic Compounds, 1-Ring --- Heterocyclic Compounds, 2-Ring --- Phenomena and Processes --- Publication Characteristics --- Heterocyclic Compounds --- Metabolic Diseases --- Genetic Diseases, Inborn --- Nutritional and Metabolic Diseases --- Chemicals and Drugs --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Diseases --- Purine-Pyrimidine Metabolism, Inborn Errors --- Congresses --- Metabolism --- Disorders --- Life sciences. --- Cancer research. --- Medical biochemistry. --- Biochemistry. --- Life Sciences. --- Biochemistry, general. --- Medical Biochemistry. --- Cancer Research. --- Oncology. --- Cancer research --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Heterocyclic compounds --- Uric acid

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"From 1962 to 1971, the US military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academy of Sciences (NAS) was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations are conducted every two years to review newly available literature and draw conclusions from the overall evidence.Veterans and Agent Orange: Update 2012 reviews peer-reviewed scientific reports concerning associations between health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published in October 2010--September 2012 and integrates this information wi650 th the previously established evidence database. This report considers whether a statistical association with herbicide exposure exists, taking into account the strength of the scientific evidence and the appropriateness of the statistical and epidemiological methods used to detect the association; the increased risk of disease among those exposed to herbicides during service in the Republic of Vietnam during the Vietnam era; and whether there exists a plausible biological mechanism or other evidence of a causal relationship between herbicide exposure and the disease"--Publisher's description.

Vietnam War, 1961-1975 -- Veterans -- Diseases. --- Vietnam War, 1961-1975 -- Veterans -- Health aspects. --- Agent Orange --- Vietnam War, 1961-1975 --- Herbicides --- Epidemiology --- Heterocyclic Compounds, 1-Ring --- Pesticides --- Environmental Pollution --- Health --- North America --- History, 20th Century --- Asia, Southeastern --- Asia --- Toxic Actions --- Agrochemicals --- Heterocyclic Compounds --- History, Modern 1601 --- -Population Characteristics --- Americas --- Public Health --- Specialty Uses of Chemicals --- Chemical Actions and Uses --- History --- Chemicals and Drugs --- Environment and Public Health --- Geographic Locations --- Health Care --- Geographicals --- Humanities --- Defoliants, Chemical --- Tetrachlorodibenzodioxin --- United States --- Vietnam --- Vietnam Conflict --- Occupational Exposure --- Dioxins --- Environmental Exposure --- Veterans Health --- Toxicology --- Health aspects --- Veterans --- Diseases --- Health aspects. --- Diseases. --- Toxicology.

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Around-the-clock tobacco talks, multibillion-dollar lawsuits against the major cigarette companies, and legislative wrangling over how much to tax a pack of cigarettes-these are some of the most recent episodes in the war against the tobacco companies. The Cigarette Papers shows what started it all: revelations that tobacco companies had long known the grave dangers of smoking, and did nothing about it.In May 1994 a box containing 4,000 pages of internal tobacco industry documents arrived at the office of Professor Stanton Glantz at the University of California, San Francisco. The anonymous source of these "cigarette papers" was identified only as "Mr. Butts." These documents provide a shocking inside account of the activities of one tobacco company, Brown & Williamson, over more than thirty years. Quoting extensively from the documents themselves and analyzing what they reveal, The Cigarette Papers shows what the tobacco companies have known and galvanizes us to take action.

Tobacco industry --- Tobacco use --- Nicotine --- Smoking. --- Tobacco. --- Cigarettes --- Habits --- Pyridines --- Solanaceae --- Solanaceous Alkaloids --- Heterocyclic Compounds, 1-Ring --- Heterocyclic Compounds --- Embryophyta --- Streptophyta --- Viridiplantae --- Additives --- Cigar Smoking --- Cigarette Smoking --- Hookah Smoking --- Smoking, Tobacco --- Waterpipe Smoking --- Pipe Smoking --- Tobacco Smoking --- Smoking, Cigar --- Smoking, Cigarette --- Smoking, Hookah --- Smoking, Pipe --- Smoking, Waterpipe --- Nicotiana tabacums --- Nicotianas --- Tobaccos --- tabacum, Nicotiana --- Nicotine Bitartrate --- Nicotine Tartrate --- Bitartrate, Nicotine --- Tartrate, Nicotine --- Eucarya --- Eukarya --- Eukaryotes --- Eukaryotas --- Eukaryote --- Plant --- Land Plants --- Land Plant --- Plant, Land --- Plants, Land --- Compounds, Heterocyclic --- Heterocyclic Cpds, 1-Ring --- 1-Ring Heterocyclic Compounds --- 1-Ring Heterocyclic Cpds --- Heterocyclic Compounds, 1 Ring --- Heterocyclic Cpds, 1 Ring --- Angiospermae --- Liliopsida --- Magnoliopsida --- Angiosperm --- Liliopsidas --- Magnoliopsidas --- Habit Disturbances --- Habit Disturbance --- Tobacco manufacture and trade --- Tobacco products industry --- Cigarets --- Cigarette habit --- Cigarette smoking --- Tobacco smoking --- Green Plants --- Green Plant --- Plant, Green --- Plants, Green --- Solanum Alkaloids --- Alkaloids, Solanaceous --- Alkaloids, Solanum --- Acnistus --- Brugmansia --- Dunalia --- Brugmansias --- Dunalias --- -Tobacco --- -Tobacco industry --- -Cigarettes --- Tobacco products --- Plant products industry --- Smoking --- Industry --- Technology, Industry, and Agriculture --- Technology, Industry, Agriculture --- Angiosperms --- Behavior --- Alkaloids --- Behavior and Behavior Mechanisms --- Chemicals and Drugs --- Psychiatry and Psychology --- Plants --- Eukaryota --- Organisms --- Tobacco --- Business & Economics --- Industries --- Smoking Behaviors --- Smoking Habit --- Behavior, Smoking --- Behaviors, Smoking --- Habit, Smoking --- Habits, Smoking --- Smoking Behavior --- Smoking Habits --- Tertiary Sector --- Sector, Tertiary --- Sectors, Tertiary --- Tertiary Sectors --- Commerce --- Ethics, Business --- Nicotiana tabacum --- Nicotiana --- Acceptance Process --- Acceptance Processes --- Behaviors --- Process, Acceptance --- Processes, Acceptance --- Botany --- Plant Proteins --- Ethnopharmacology --- Polycyclic Compounds --- Plant Alkaloids --- Alkaloids, Plant --- Angiosperma --- Arecidae --- Asteridae --- Caryophyllidae --- Commelinidae --- Dicotyledoneae --- Dilleniidae --- Flowering Plants --- Hamamelidae --- Hamamelididae --- Icacinales --- Liliatae --- Liliidae --- Magnoliatae --- Metteniusales --- Oncothecales --- Rosidae --- Vahliales --- Zingiberidae --- Flowering Plant --- Icacinale --- Metteniusale --- Oncothecale --- Plant, Flowering --- Plants, Flowering --- Vahliale --- Piperidines --- Habit --- Health aspects. --- legislation. --- adverse effects. --- Health aspects --- United States --- Additives. --- Tobacco industry - United States. --- Tobacco - Health aspects. --- #SBIB:002.IO --- #SBIB:316.334.3M20 --- #SBIB:35H411 --- #SBIB:35H436 --- Sociale epidemiologie en etiologie: sociale aspecten van ziekte en gezondheid --- Beleidscyclus: voorbereiding (inclusief planning) --- Beleidssectoren: welzijn, volksgezondheid en cultuur --- Behavior And Behavior Mechanism --- Heterocyclic Compound --- Compound, Heterocyclic --- Alkaloid --- Plant Alkaloid --- Alkaloid, Plant --- Technology --- Psychology --- Factors, Psychological --- Psychological Factors --- Psychological Side Effects --- Psychologists --- Psychosocial Factors --- Side Effects, Psychological --- Factor, Psychological --- Factor, Psychosocial --- Factors, Psychosocial --- Psychological Factor --- Psychological Side Effect --- Psychologist --- Psychosocial Factor --- Side Effect, Psychological --- Arts, Industrial --- Industrial Arts --- Cloud Computing --- Industry. --- Cigarettes. --- Habits. --- Technology, Industry, and Agriculture. --- Pyridines. --- Solanaceae. --- Solanaceous Alkaloids. --- Technology. --- Magnoliopsida. --- Behavior. --- Alkaloids. --- Heterocyclic Compounds, 1-Ring. --- Heterocyclic Compounds. --- Embryophyta. --- Behavior and Behavior Mechanisms. --- Psychology. --- Streptophyta. --- Viridiplantae. --- Plants. --- Eukaryota. --- Nicotine. --- United States.