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This edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus. The chapters not only discuss genetics and molecular evolution of the virus, but also new structure-based knowledge on the functions of viral glycoproteins. Further, the authors illustrate how mechanisms from the virus are used to take over and remodel host cells during pathogeneis. These mechanisms also enable viral modulation of host cells and evasion of the host immune response. Part of these evasion and survival strategies, is the reaction to triggered host cell responses like autophagy, the stress response, modulation of apoptosis and other cell death pathways. This hands-on knowledge is crucial for students and clinicians in Virology, Immunology, and Infectious Diseases. Chapter "Common features between stroke following varicella in children and stroke following herpes zoster in adults" is available open access under a Creative Commons Attribution 4.0 International License via Springerlink.com.

Varicella-zoster virus. --- Chickenpox virus --- Herpes zoster virus --- Human herpesvirus-3 --- Varicella virus --- VZ virus --- Herpesviruses --- Virology. --- Immunology. --- Human physiology. --- Vaccines --- Biomaterials. --- Human Physiology. --- Biomaterials-Vaccines. --- Biotechnology. --- Vaccine biotechnology --- Biotechnology --- Human biology --- Medical sciences --- Physiology --- Human body --- Immunobiology --- Life sciences --- Serology --- Microbiology --- Biomedical materials.

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Herpes zoster ophthalmicus (HZO) is a common disease in the elderly and the immunosuppressed, with potentially devastating sequelae. Diagnosis of HZO is clinical but almost all its manifestations are non-specific and often indistinguishable from those due to other causes in general and herpes simplex virus in particular. The exception is varicella-zoster virus epithelial keratitis, which is frequently the only indicator of the true nature of the disease. This book is unique in presenting high-magnification images, obtained by non-contact in vivo photomicrography, that capture the distinctive features of varicella-zoster virus epithelial keratitis in HZO. Both the morphology and the dynamics of the corneal epithelial lesions are splendidly documented, including in patients with HZO sine herpete and recurrent disease. Three rare cases of ocular surface involvement in acute HZO are included, and the final chapter offers an illuminating comparison of varicella-zoster virus epithelial keratitis in HZO and the lesions of herpes simplex virus. This book will serve as an indispensable aid in the prompt diagnosis of HZO.

Diseases -- Elderly. --- Emerging infectious diseases. --- Eye -- Diseases -- Elderly. --- Eye -- Diseases. --- Geriatrics. --- Ophthalmology. --- Varicellovirus --- Herpes Simplex --- Eye Infections, Viral --- Herpes Zoster --- Keratitis --- Eye Infections --- Herpesviridae Infections --- Virus Diseases --- Alphaherpesvirinae --- Corneal Diseases --- Herpesviridae --- Eye Diseases --- DNA Virus Infections --- Diseases --- DNA Viruses --- Vertebrate Viruses --- Viruses --- Herpesvirus 3, Human --- Keratitis, Herpetic --- Herpes Zoster Ophthalmicus --- Organisms --- Medicine --- Health & Biological Sciences --- Ophthalmology & Optometry --- Ophthalmic zoster. --- Varicella-zoster virus. --- Keratitis. --- Cornea --- Virus diseases. --- Diseases. --- Keratomalacia --- Chickenpox virus --- Herpes zoster virus --- Human herpesvirus-3 --- Varicella virus --- VZ virus --- Ganglionitis, Gasserian --- Gasserian ganglionitis --- Herpes ophthalmicus --- Herpes zoster ophthalmicus --- Ocular herpes zoster --- Ocular zoster --- Medicine. --- Infectious diseases. --- Medicine & Public Health. --- Infectious Diseases. --- Viral diseases --- Viral infections --- Virus infections --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Eye --- Herpesviruses --- Shingles (Disease) --- Inflammation --- Infections --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases