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Quatrième de couverture : "Un guide de référence sur les principales drogues d'origine végétale, leurs usages dans l'histoire et dans le présent, les pays où elles sont cultivées, leurs effets et leurs dangers éventuels ainsi que les aspects légaux de leur production ou consommation. Au fil de son histoire, l'homme a appris à connaître les espèces végétales qui agissent sur son psychisme, lui permettant d'entrer dans des états modifiés de conscience et de perception, de s'élever au-dessus de sa condition, de planer, voire d'entrer en communication avec dieux ou esprits. Les chamans de diverses civilisations ont fait appel à ces plantes pour communiquer avec la Nature, poser un diagnostic et trouver le remède adapté à une maladie; les artistes y ont puisé créativité et inspiration; les curieux explorent des mondes intérieurs et les métamorphoses des sens. Les psychotropes provoquent des effets psychiques et physiques tels que des perturbations des perceptions, des hallucinations ou des modifications de l'humeur ou de la pensée. Sensation de bien-être, euphorie, sentiment de se surpasser : certaines sont addictives, d'où leur classement dans la liste des stupéfiants prohibés. Mais quelques psychotropes présentent aussi un immense potentiel thérapeutique encore peu exploité, suscitant un intérêt croissant dans les milieux scientifiques. Le cannabis et ses constituants (THC et CBD) sont par exemple efficaces contre les douleurs et les spasmes de la sclérose en plaques ; les composants des champignons hallucinogènes, contre la dépression et le stress post-traumatique; le LSD, pour apaiser les malades en fin de vie terrifiés par la mort. Depuis la première édition de cet ouvrage en 2002, beaucoup de choses se sont passées : l'interdiction de la sauge divinatoire en Suisse et en Belgique, du kratom en Suisse et de l'ayahuasca en France, mais aussi la possibilité d'avoir accès au cannabis thérapeutique en Suisse et en France. Il y a eu aussi l'arrivée de nouvelles drogues comme l'hortensia, phénomème éphémère, ou le changa, version fumée de l'ayahuasca d'Amérique du Sud, qui séduit toujours plus d'Occidentaux. L'histoire de ces drogues, le hasard de leur découverte, leurs effets et modes d'action, leurs dangers et leurs cadres légaux sont présentés dans cet ouvrage actualisé avec de nombreuses anecdotes étonnantes, des onguents aphrodisiaques des sorcières du Moyen Âge aux buveurs d'urine de consommateurs d'amanites tue-mouches, en passant par le culte qu'une secte moderne voue à des crapauds à la peau hallucinogène..."

Plants, Medicinal --- Hallucinogens --- Psychotropic Drugs --- Herb-Drug Interactions --- Herbal Medicine

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This book focuses on efficacy, toxicity, drug interactions, and abnormal clinical laboratory tests resulting from the use of herbal remedies. Although a few herbal remedies are safe and have efficacy (for example saw palmetto), many herbal remedies are toxic. This book guides in the interpretation of abnormal test results in otherwise healthy subjects due to use of herbal remedies. Chapters focus on interactions between herbals and pharmaceuticals, sources of contamination in herbal supplements, and analytical techniques used in the investigation of herbal remedies.

Herbs --- Drug-herb interactions. --- Toxicology. --- Therapeutic use. --- Herb-drug interactions --- Interactions, Drug-herb --- Drug interactions --- Herb remedies --- Herbal medicine --- Medicinal herbs --- Plants, Useful --- Forbs

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Drug interactions --- Geneesmiddelen -- Wisselwerking --- Interactions médicamenteuses --- Medicaments -- Interactions --- Drug Interactions --- Herb-drug interactions --- Food-drug interactions --- Antagonisme médicamenteux --- Interaction médicaments-plantes --- Médicaments --- Interaction --- Aliments --- Handbooks, manuals, etc. --- Guides, manuels, etc --- Interactions médicamenteuses --- Drug Interactions. --- Antagonisme médicamenteux. --- Interaction médicaments-plantes. --- Aliments. --- Herb-Drug Interactions. --- Food-Drug Interactions. --- Food-Drug Interactions

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Plant ecophysiology --- Plants. --- Toxicology. --- Plant ecophysiology. --- Life Sciences --- Botany --- Plants --- Toxins --- Plant --- Environmental plant physiology --- Physiological plant ecology --- Plant physiological ecology --- plant biology --- plant physiology --- ecology --- environmental engineering --- agronomy --- Plant Proteins --- Ethnopharmacology --- Ecophysiology --- Plant ecology --- Plant physiology --- Plant ecology. Plant sociology --- Plant husbandry --- Toxins. --- Toxins, Biological. --- Biological Toxins --- Toxoids --- Plant Physiological Phenomena. --- Herb-Drug Interactions. --- Drug-Herb Interactions --- Drug-Plant Interactions --- Herbal Drug Interactions --- Plant-Drug Interactions --- Adverse Herb-Drug Interactions --- Beneficial Herb-Drug Interactions --- Adverse Herb Drug Interactions --- Adverse Herb-Drug Interaction --- Beneficial Herb Drug Interactions --- Beneficial Herb-Drug Interaction --- Drug Herb Interactions --- Drug Interaction, Herbal --- Drug Interactions, Herbal --- Drug Plant Interactions --- Drug-Herb Interaction --- Drug-Plant Interaction --- Herb Drug Interactions --- Herb-Drug Interaction --- Herb-Drug Interaction, Adverse --- Herb-Drug Interaction, Beneficial --- Herb-Drug Interactions, Adverse --- Herb-Drug Interactions, Beneficial --- Herbal Drug Interaction --- Interaction, Adverse Herb-Drug --- Interaction, Beneficial Herb-Drug --- Interaction, Drug-Herb --- Interaction, Drug-Plant --- Interaction, Herb-Drug --- Interaction, Herbal Drug --- Interaction, Plant-Drug --- Interactions, Adverse Herb-Drug --- Interactions, Beneficial Herb-Drug --- Interactions, Drug-Herb --- Interactions, Drug-Plant --- Interactions, Herb-Drug --- Interactions, Herbal Drug --- Interactions, Plant-Drug --- Plant Drug Interactions --- Plant-Drug Interaction --- Metabolic Side Effects of Drugs and Substances --- Physiology, Plant --- Plant Physiologic Phenomena --- Plant Physiologic Phenomenon --- Plant Physiological Phenomenon --- Plant Physiological Process --- Plant Physiological Processes --- Plant Physiology --- Phenomena, Plant Physiologic --- Phenomena, Plant Physiological --- Phenomenon, Plant Physiologic --- Phenomenon, Plant Physiological --- Phenomenons, Plant Physiological --- Physiologic Phenomena, Plant --- Physiologic Phenomenon, Plant --- Physiological Phenomena, Plant --- Physiological Phenomenon, Plant --- Physiological Phenomenons, Plant --- Physiological Process, Plant --- Physiological Processes, Plant --- Plant Physiological Phenomenons --- Process, Plant Physiological --- Processes, Plant Physiological --- physiology --- Plants, Toxic. --- Plant Poisoning. --- Plantes --- Écophysiologie --- Plants, Toxic --- Plant Physiological Phenomena

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Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resurgence in interest and use of plant-based therapies and botanical products, and natural products remain an important and viable source of lead compounds in many drug discovery programs.This Special Issue on “Plant Natural Products for Human Health” compiles a series of scientific reports to demonstrate the medicinal potentials of plant natural products. It covers a range of disease targets, such as diabetes, inflammation, cancer, neurological disease, cardiovascular disease, liver damage, bacterial, and fungus infection and malarial. These papers provide important insights into the current state of research on drug discovery and new techniques. It is hoped that this Special Issue will serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.

PhGs --- bitter orange --- immunomodulator --- A549 cells --- bergapten --- triptolide --- BMP/Smad --- phytochemicals --- antioxidant enzymes --- kumquat --- MTT assay --- HepaRG cells --- human health --- nanoparticles --- dendritic cells --- drug discovery --- biofilm --- catechin --- antitubercular activity --- Panax notoginseng saponins --- animals --- mouse-hair growth --- A? --- curcumin --- WNT/?-catenin --- copaiba --- AD --- Plasmodium parasites --- traditional medicine --- procyanidin A2 --- PET inhibition --- rheumatoid arthritis --- cannabinoid type 1 receptor --- iridoids --- inflammatory bowel disease --- acute liver injury --- human-hair-follicle dermal papilla cells --- Neuroprotective --- dihydromyricetin --- AMPK --- thromboembolism --- ginseng --- drug design and development --- endoplasmic reticulum stress --- mitogen-activated protein kinase --- Nrf2 --- prenylated flavonoids --- inflammation --- preclinical studies --- plants --- dietary supplements --- Glycyrrhiza uralensis --- aspirin --- Tripterygium wilfordii --- P. eryngii --- reperfusion --- ethnopharmacology --- glucans --- innovation --- hpatoprotection --- hinokitiol --- phytocannabinoid --- antistaphylococcal activity --- Shh/Gli --- green tea --- sesquiterpenoids --- adjuvant-induced arthritis --- yuzu --- hepatotoxicity --- p53/Bax --- Keap1 --- nuclear factor-kappaB --- oxidative stress --- pharmacokinetic study --- cinnamamides --- toxicity --- APAP --- Astragali Radix --- computational softwares --- plant natural product --- onion --- anti-malaria activity --- lipogenesis --- bleeding time --- diterpenoids --- Penthorum chinense Pursh --- myocardial hypertrophy --- automation --- adjuvant --- grapefruit --- melanoma cell --- essential oil --- sweet orange --- Amadori rearrangement compounds --- heme oxygenase --- global health --- calorie restriction --- bergamot --- liposomes --- EGCG --- celastrol --- herb–drug interactions --- cannabigerol --- anti-inflammation --- OH· free radical --- molecular targets --- gluconeogenesis --- microbiome --- SIRT1 --- fucoidan --- heart --- PC12 cells --- acetaminophen --- omics --- time-kill assay --- arthritis --- lychee seed --- bioinformatics --- structure–activity relationship --- precision medicine --- orange petitgrain --- immune modulation --- antiproliferation --- flavonoids --- scoulerine --- oleoresin --- triterpenic acids --- Cannabis sativa --- NAFLD --- biological activity --- differentiation --- oxygen consumption rate --- mitochondrial bioenergetics --- neroli --- apoptosis --- targeted delivery --- platelet activation --- protein kinase --- heat-process --- hepatic steatosis --- hyperglycemia --- natural products --- lemon --- genistein --- neuroinflammation --- astragaloside IV --- cytoxicity --- flavonoid --- paracetamol --- medicinal plants --- insulin resistance --- resveratrol --- mandarin --- garlic --- TGF-? --- morin hydrate --- sirtuin 3 --- MMPs --- gomisin N --- lime --- Ziziphus jujuba --- antifungal activity --- ischemia --- migration --- caspases --- small molecules --- PhGs --- bitter orange --- immunomodulator --- A549 cells --- bergapten --- triptolide --- BMP/Smad --- phytochemicals --- antioxidant enzymes --- kumquat --- MTT assay --- HepaRG cells --- human health --- nanoparticles --- dendritic cells --- drug discovery --- biofilm --- catechin --- antitubercular activity --- Panax notoginseng saponins --- animals --- mouse-hair growth --- A? --- curcumin --- WNT/?-catenin --- copaiba --- AD --- Plasmodium parasites --- traditional medicine --- procyanidin A2 --- PET inhibition --- rheumatoid arthritis --- cannabinoid type 1 receptor --- iridoids --- inflammatory bowel disease --- acute liver injury --- human-hair-follicle dermal papilla cells --- Neuroprotective --- dihydromyricetin --- AMPK --- thromboembolism --- ginseng --- drug design and development --- endoplasmic reticulum stress --- mitogen-activated protein kinase --- Nrf2 --- prenylated flavonoids --- inflammation --- preclinical studies --- plants --- dietary supplements --- Glycyrrhiza uralensis --- aspirin --- Tripterygium wilfordii --- P. eryngii --- reperfusion --- ethnopharmacology --- glucans --- innovation --- hpatoprotection --- hinokitiol --- phytocannabinoid --- antistaphylococcal activity --- Shh/Gli --- green tea --- sesquiterpenoids --- adjuvant-induced arthritis --- yuzu --- hepatotoxicity --- p53/Bax --- Keap1 --- nuclear factor-kappaB --- oxidative stress --- pharmacokinetic study --- cinnamamides --- toxicity --- APAP --- Astragali Radix --- computational softwares --- plant natural product --- onion --- anti-malaria activity --- lipogenesis --- bleeding time --- diterpenoids --- Penthorum chinense Pursh --- myocardial hypertrophy --- automation --- adjuvant --- grapefruit --- melanoma cell --- essential oil --- sweet orange --- Amadori rearrangement compounds --- heme oxygenase --- global health --- calorie restriction --- bergamot --- liposomes --- EGCG --- celastrol --- herb–drug interactions --- cannabigerol --- anti-inflammation --- OH· free radical --- molecular targets --- gluconeogenesis --- microbiome --- SIRT1 --- fucoidan --- heart --- PC12 cells --- acetaminophen --- omics --- time-kill assay --- arthritis --- lychee seed --- bioinformatics --- structure–activity relationship --- precision medicine --- orange petitgrain --- immune modulation --- antiproliferation --- flavonoids --- scoulerine --- oleoresin --- triterpenic acids --- Cannabis sativa --- NAFLD --- biological activity --- differentiation --- oxygen consumption rate --- mitochondrial bioenergetics --- neroli --- apoptosis --- targeted delivery --- platelet activation --- protein kinase --- heat-process --- hepatic steatosis --- hyperglycemia --- natural products --- lemon --- genistein --- neuroinflammation --- astragaloside IV --- cytoxicity --- flavonoid --- paracetamol --- medicinal plants --- insulin resistance --- resveratrol --- mandarin --- garlic --- TGF-? --- morin hydrate --- sirtuin 3 --- MMPs --- gomisin N --- lime --- Ziziphus jujuba --- antifungal activity --- ischemia --- migration --- caspases --- small molecules