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This special issue of the International Journal of Molecular Sciences contains a collection of articles by colleagues of Antonius (Ton) Gerardus Rolink (19/04/1953-06/08/2017) and honors Ton's life and profound knowledge of and huge contribution to science. Ton participated in an FP7 Marie Curie Initial Training Network called DECIDE, and partners have submitted articles for this Special Issue. Scientists outside this network have also submitted articles. The articles examine various aspects of how the hematopoietic stem-cell gives rise to the different types of blood and immune cells. These include decision-making by the hematopoietic stem cell and the importance of controlling events within cells and the niches the cell resides in. New insights into these processes at the basic scientific level have given rise to an emerging new model for the development of blood cells. In turn, changes to our understanding of this process have led to new and exciting propositions regarding what goes wrong during the early stages of the development of leukemia.

Cell lines. --- Hematopoiesis. --- Blood formation --- Hemopoiesis --- Blood --- Cell culture

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Erythropoietin --- Erythropoietine --- Erytropoetine --- Facteurs de croissance hématopoïétiques --- Hematopoese --- Hematopoiese --- Hematopoiesis --- Hematopoietic growth factors --- Hematopoëtische groeifactoren --- Anemia --- Blood --- Hematopoietic Cell Growth Factors --- Hematopoietic cell growth factors --- Hematopoietins --- HGF (Growth factors) --- Growth factors --- Blood formation --- Hemopoiesis --- Colony-stimulating factors (Physiology) --- blood. --- drug effects. --- pharmacology. --- Erythropoietin. --- Hematopoiesis. --- Hematopoietic growth factors. --- ANEMIA --- BLOOD --- HEMATOPOIESIS --- HEMATOPOIETIC CELL GROWTH FACTORS --- blood --- drug effects --- pharmacology --- Blood. --- Drug effects. --- Pharmacology.

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"Manual of Hematopoietic Cell Transplantation and Cellular Therapies is a comprehensive, focused reference covering the latest clinical developments and applications of stem cell transplant and cellular therapies for hematologic malignancies and solid tumors. This cutting-edge title, with a majority contribution from the MD Anderson Cancer Center and leading faculty from other academic institutions, covers breakthrough cell-based therapies for various diseases including lymphoma, multiple myeloma, leukemia, and select solid tumor and autoimmune diseases. This unique, definitive resource is essential for hematologists, fellows in hematology and immunotherapy, mid-level providers, pharmacists, and oncologists who refer patients for cell-based therapies. Addresses hematologic conditions including leukemia, lymphoma, and myeloma"-- ǂc Publisher's description.

Blood --- Cell transplantation. --- Cellular therapy. --- Diseases. --- Cell therapy --- Cells --- Therapy, Cellular --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Cellular transplantation --- Cellular therapy --- Clinical hematology --- Hematologic diseases --- Hematology --- Therapeutic use --- Transplantation --- Hematopoiesis. --- Tumors. --- Hematopoietic Stem Cell Transplantation --- Cell- and Tissue-Based Therapy --- Hematologic Neoplasms --- Neoplasms --- methods --- therapy --- Cell- and Tissue-Based Therapies --- Tumours --- Pathology --- Cysts (Pathology) --- Oncology --- Blood formation --- Hemopoiesis --- Hematopoiesis --- Hematologic Diseases

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Although much is known with respect to blood cell formation and function many new concepts in regulation of hematopoietic stem cell commitment and subsequent survival, proliferation and differentiation of progenitors have been elucidated in the last five years. Our understanding of the microenvironment where stem cells reside (the niche) and commit to distinct blood types has grown significantly in recent years. Furthermore, blood cells have been used as the key model system to study microRNA function and the role of micro RNAs in transformation of normal cells into cancer cells. The current volume "Molecular Basis of Hematopoiesis," edited by Amittha Wickrema & Barbara Kee provides the most recent developments in the above mentioned areas in addition to a chapter on utilization of basic science knowledge for treatment of blood diseases. Each chapter in this book has been written and edited by faculty in major academic and research institutions around the world working directly in hematopoietic cell research who are pushing the frontiers of biology. .

Cytology. --- Oncology. --- Toxicology. --- Hematopoietic stem cells --- Hematopoiesis --- Hematopoietic Stem Cells --- Bone Marrow Cells --- Blood Physiological Processes --- Cell Differentiation --- Blood Physiological Phenomena --- Cells --- Cell Physiological Processes --- Circulatory and Respiratory Physiological Phenomena --- Cell Physiological Phenomena --- Anatomy --- Phenomena and Processes --- Physiology --- Oncology --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Hematopoietic stem cells. --- Hematopoiesis. --- Blood formation --- Hemopoiesis --- HSCs (Hematopoietic stem cells) --- Medicine. --- Cancer research. --- Pharmacology. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Pharmacology/Toxicology. --- Blood --- Blood cells --- Bone marrow cells --- Hematopoietic system --- Multipotent stem cells --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Tumors --- Toxicology --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Cell Differentiation --- Cell Transformation, Neoplastic --- Cells, Cultured --- Hematopoiesis --- Hematopoietic Stem Cells --- Leukemia --- Stem Cells --- cytology --- Cell Differentiation. --- Cell Transformation, Neoplastic. --- Cells, Cultured. --- Hematopoiesis. --- Leukemia. --- Blood formation --- Hemopoiesis --- Blood --- Leucocythaemia --- Leucocythemia --- Leucocythaemias --- Leucocythemias --- Leukemias --- Myeloproliferative Disorders --- Hematologic Neoplasms --- Cultured Cells --- Cell, Cultured --- Cultured Cell --- Organ Culture Techniques --- Coculture Techniques --- Cell Culture Techniques --- Culture Techniques --- Human Umbilical Vein Endothelial Cells --- Haematopoiesis --- Hematopoiesis, Medullary --- Medullary Hematopoiesis --- Neoplastic Cell Transformation --- Transformation, Neoplastic Cell --- Tumorigenic Transformation --- Neoplastic Transformation, Cell --- Cell Neoplastic Transformation --- Cell Neoplastic Transformations --- Cell Transformations, Neoplastic --- Neoplastic Cell Transformations --- Neoplastic Transformations, Cell --- Transformation, Cell Neoplastic --- Transformation, Tumorigenic --- Transformations, Cell Neoplastic --- Transformations, Neoplastic Cell --- Transformations, Tumorigenic --- Tumorigenic Transformations --- Cell Line, Transformed --- Differentiation, Cell --- Cell Differentiations --- Differentiations, Cell --- Embryo, Mammalian --- Gene Expression Regulation --- Cell Lineage --- cytology.