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Cytokines --- Hematopoietic growth factors --- Monocyctes --- Hematopoietic Cell Growth Factors --- Phagocytes --- Congresses --- immunology --- physiology

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Enormous effort has been spent developing many new laboratory techniques for studying immune cells and the immune system, not only to increase fundamental understanding, but also to procure therapeutic success in a clinical setting. In Cytokines and Colony Stimulating Factors: Methods and Protocols, leading laboratory experts describe for the novice investigator a host of novel technologies and molecular techniques specifically designed to study cellular immunology and promote its gene therapy applications. Presented in step-by-step detail to ensure ready reproducibility, these protocols range from flow cytometric techniques to detect cytokines and growth factors in different specimens, to methods for generating and expanding dendritic cells and hematopoietic progenitors from different origins. Each proven method has been fine-tuned for experimental successs by the investigator who developed it, and includes notes on troubleshooting and avoiding potential pitfalls. Although the protocols require little previous experience, even highly skilled researchers will augment their experimental range with many novel timesaving techniques. Cutting-edge and highly practical, Cytokines and Colony Stimulating Factors: Methods and Protocols provides researchers a carefully evaluated set of powerful tools for successful experimental research on cytokines and their role in gene therapy.

Cytokines --- Colony-stimulating factors (Physiology) --- Glycoproteins --- Hematopoietic growth factors --- Cellular immunity --- Immune response --- Regulation --- Immunology. --- Immunobiology --- Life sciences --- Serology

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Cancer --- Drugs --- Hematopoietic growth factors --- Antineoplastic Agents --- Dose-Response Relationship, Drug --- Hematopoietic Cell Growth Factors --- Neoplasms --- Chemotherapy --- Complications --- Prevention --- Dosage --- Therapeutic use --- pharmacology --- therapeutic use --- drug therapy

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Erythropoietin and the Nervous System is the first book of its kind to bring together researchers from many different disciplines of neuroscience to present a current state-of-the-art review of multiple aspects of erythropoietin research as it relates to the nervous system. Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body. In addition to its traditional role as a hormone that stimulates red blood cell production, in recent years many laboratories have shown that EPO can act as a neuroprotective compound in a variety of injury paradigms in the nervous system. Past experience with the relatively safety profile of this FDA-approved drug makes it an ideal candidate to take into clinical trials for neuroprotection. We are on the verge of major clinical trials using this drug for neuroprotection in diseases ranging from stroke, to transverse myelitis to chemotherapy-induced peripheral neuropathy. This book should stimulate new research on erythropoietin and the nervous system and bring new investigators to the field. It will benefit scientists and clinicians interested in neuroprotection in the broadest sense.

Erythropoietin --- Physiological aspects. --- Colony-stimulating factors (Physiology) --- Hematopoietic growth factors --- Neurology. --- Neurosciences. --- Psychiatry. --- Neurosurgery. --- Nerves --- Neurosurgery --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Medicine --- Neuropsychiatry --- Surgery --- Diseases --- Neurology .

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No area of cancer supportive care better illustrates the advances in our understanding of cellular and molecular biology, genetic engineering and the development of more effective yet often more toxic cancer treatments than that of hematopoietic growth factors. Myelosuppressive agents, with their potential hematopoietic toxicities, remain the mainstay of systemic treatment for both metastatic and early stage cancer. Hematopoietic Growth Factors in Oncology reviews and integrates the major advances in our understanding of the underlying molecular biology and pharmacology of these agents along with the results of well designed and executed randomized controlled trials of the erythroid stimulating agents, the myeloid growth factors and the new thrombopoietic agents, each addressing a major threat associated with bone marrow suppression accompanying cancer treatment. "Hematopoietic growth factors have revolutionized the treatment of patients with a spectrum of cancers and benign bone marrow disorders. This text addresses the mechanism of action and clinical impact of these cytokines. Leading investigators in the field provide and update of current state of knowledge and future challenges." – Steven T. Rosen, M.D. Series Editor.

Cancer -- Chemotherapy. --- Electronic books. -- local. --- Hematopoietic growth factors -- Therapeutic use. --- Hematopoietic growth factors --- Oncology --- Hematopoietic Cell Growth Factors --- Diseases --- Glycoproteins --- Biological Science Disciplines --- Therapeutics --- Proteins --- Natural Science Disciplines --- Cytokines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Colony-Stimulating Factors --- Drug Therapy --- Neoplasms --- Pharmacology --- Amino Acids, Peptides, and Proteins --- Intercellular Signaling Peptides and Proteins --- Disciplines and Occupations --- Peptides --- Chemicals and Drugs --- Biological Factors --- Medicine --- Health & Biological Sciences --- Mechanism of action --- Cancer --- Therapeutic use. --- Chemotherapy. --- Hematopoietic cell growth factors --- Hematopoietins --- HGF (Growth factors) --- Medicine. --- Oncology. --- Medicine & Public Health. --- Antineoplastic agents --- Growth factors --- Treatment --- Oncology  . --- Tumors