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Proefschriften --- Thèses --- Lung diseases --- Cadnium poisoning --- Heat-shock response --- Heat-shock proteins --- Chemically induced --- Physiopathology
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HSP70 Heat-Shock Proteins --- Protein Folding --- Transcription Factors --- Heat-Shock Response --- metabolism --- metabolism --- physiology
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Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.
molecular chaperone --- therapeutics --- neurodegenerative disease --- heat-shock response --- protein misfolding --- neuroprotection --- neurodegeneration --- heat-shock protein --- proteostasis --- amyloid protein --- molecular chaperone --- therapeutics --- neurodegenerative disease --- heat-shock response --- protein misfolding --- neuroprotection --- neurodegeneration --- heat-shock protein --- proteostasis --- amyloid protein
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Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.
molecular chaperone --- therapeutics --- neurodegenerative disease --- heat-shock response --- protein misfolding --- neuroprotection --- neurodegeneration --- heat-shock protein --- proteostasis --- amyloid protein
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Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.
molecular chaperone --- therapeutics --- neurodegenerative disease --- heat-shock response --- protein misfolding --- neuroprotection --- neurodegeneration --- heat-shock protein --- proteostasis --- amyloid protein
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Multi-disciplinary peer-reviewed journal that captures the eclectic spirit of the cellular stress response field in a single, concentrated source of current information.
Histology. Cytology --- Drug Toxicity --- Heat-Shock Response --- Metals --- Molecular Chaperones --- Oxidative Stress --- Cytology --- Stress (Physiology) --- Oxidative stress --- Molecular chaperones --- Cytologie --- Stress --- Stress oxydatif --- Molécules chaperonnes --- toxicity --- Periodicals. --- Périodiques --- Cell Survival. --- Drug-Related Side Effects and Adverse Reactions. --- Heat-Shock Response. --- Molecular Chaperones. --- Oxidative Stress. --- Cytology. --- Molecular chaperones. --- toxicity. --- 576 --- 57 --- Cellular and subcellular biology. Cytology --- Biological sciences in general --- Periodicals --- Health Sciences --- Life Sciences --- Pathology --- Biology --- Cytology, Cell Biology --- Micro and Molecular Biology --- Toxicology --- 576 Cellular and subcellular biology. Cytology --- Proteins
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"Heat Exposure and Human Health in the Context of Climate Change introduces the effects of heat on human health, especially in the context of climate change. The book utilizes case studies in addition to foundational knowledge and theory to demonstrate the epidemiological impact of heat, also presenting solutions for addressing this important public health issue. It is clearly organized to aid in understanding key questions such as why and how heat exposure impacts health, who are most vulnerable to heat exposure, and how to reduce the impacts of heat exposure. Providing guidance on public policy development as well as individual protection, this book is an interdisciplinary resource for researchers and policymakers in both public health and environmental science fields."--
Climatic changes --- Heat --- Health aspects. --- Physiological effect. --- Heat stress (Biology) --- High temperatures --- Hyperthermia --- Changes, Climatic --- Changes in climate --- Climate change --- Climate change science --- Climate changes --- Climate variations --- Climatic change --- Climatic fluctuations --- Climatic variations --- Global climate changes --- Global climatic changes --- Climatology --- Climate change mitigation --- Global environmental change --- Teleconnections (Climatology) --- Physiological effect --- Environmental aspects --- Climate Change --- Hot Temperature --- Heat Stress Disorders --- Heat-Shock Response --- adverse effects
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Animals living in the Southern Ocean have evolved in a singular environment. It shares many of its attributes with the high Arctic, namely low, stable temperatures, the pervading effect of ice in its many forms and extreme seasonality of light and phytobiont productivity. Antarctica is, however, the most isolated continent on Earth and is the only one that lacks a continental shelf connection with another continent. This isolation, along with the many millions of years that these conditions have existed, has produced a fauna that is both diverse, with around 17,000 marine invertebrate species living there, and has the highest proportions of endemic species of any continent. The reasons for this are discussed. The isolation, history and unusual environmental conditions have resulted in the fauna producing a range and scale of adaptations to low temperature and seasonality that are unique. The best known such adaptations include channichthyid icefish that lack haemoglobin and transport oxygen around their bodies only in solution, or the absence, in some species, of what was only 20 years ago termed the universal heat shock response.
Marine biology. --- Oceanography. --- oceanography --- marine biology --- environment --- climate change --- climate change impacts --- Southern Ocean --- high Arctic --- ice --- seasonality --- phytobiont productivity --- Antarctica --- Antarctic fauna --- marine invertebrate species --- endemic species --- low temperature adaptations --- seasonality adaptions --- channichthyid icefish --- universal heat shock response --- gametogenic cycles --- vitellogenesis --- microtubule assembly --- locomotion --- metabolic rate --- whole-animal growth --- embryonic development --- limb regeneration --- echinoderms --- Southern Ocean fauna --- ecophysiological adaptations --- coldblooded marine species
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This book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects. This adaptive response to high temperature or protein misfolding is a fundamental mechanism to maintain the capacity of protein homeostasis, or proteostasis, and is evolutionally conserved among all living organisms, including bacteria and humans, on the earth. Furthermore, physiological and pathological roles of HSF have been extensively studied in fruit fly, worm, and mouse models. It has been revealed that HSF plays roles in development of the brain, reproductive and sensory organs, and in ageing, inflammation, and circadian rhythm. Analysis of the mechanisms have uncovered that HSF exerts a wide range of effects on gene expression and epigenetic status on the whole genome. Moreover, loss or gain of HSF function is also closely related to protein-misfolding diseases including neurodegenerative diseases, psychiatric diseases, heart diseases, and cancers. Therefore, HSF is now thought to be a promising therapeutic target for treatment of these refractory diseases. For undergraduate students, this is a highly understandable source of information on heart shock response and HSF, covering the basis of HSF biology, the physiological role of HSF, and disease associated with HSF function. This book not only serves as a guide to the heat shock response and HSF for students and young researchers in other fields, but also is a cornerstone for future work in the field related to the heat shock response and HSF.
Heat shock proteins --- Heat-Shock Response --- Heat-Shock Proteins --- Protein Folding --- Physiology --- Transcription Factors --- Biophysical Processes --- Proteins --- Biological Science Disciplines --- Stress, Physiological --- Molecular Chaperones --- Physiological Processes --- Natural Science Disciplines --- Biophysical Phenomena --- Amino Acids, Peptides, and Proteins --- Physical Phenomena --- Disciplines and Occupations --- Chemicals and Drugs --- Physiological Phenomena --- Phenomena and Processes --- Cytology --- Biology --- Health & Biological Sciences --- Heat shock proteins. --- Stress proteins --- Cytology. --- Biochemistry. --- Human physiology. --- Cell Biology. --- Protein Science. --- Human Physiology. --- Animal Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Human biology --- Human body --- Composition --- Cell biology. --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics
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Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease provides the most current review of the literature relating to the role and influence of heat shock (stress) proteins on the establishment, progression and resolution of infectious disease. Written by leaders in the field of heat shock proteins (HSP) and their biological and immunological properties, the contributors provide a fascinating insight into the complex relationship between, and the involvement of prokaryotic and eukaryotic HSP in disease states. It has been known for some considerable time that heat shock proteins from prokaryotic organisms are immunodominant molecules that are intimately involved in the induction of potential protective inflammatory responses, and this aspect of HSP biology is updated herein. In addition to regulating heat shock protein gene expression, the transcription factor HSF1 also appears to play an important role in regulating immune responses to infection. Heat shock proteins are now known to influence infectious disease processes in a number of diverse ways: they are involved in the propagation of prions, the replication and morphogenesis of viruses, and the resistance of parasites to chemotherapy. These proteins also appear to be important mediators of bacteria-host interactions and inflammation, the latter via interactions with cell surface molecules and structures such as Toll-like receptors and lipid rafts. Heat shock proteins can be expressed on the surface of infected cells, and this is likely to provide a target for the innate immune response. Elevated levels of circulating HSP are present in infectious diseases and these proteins might therefore regulate inflammatory responses to pathogenic challenge on a systemic basis. Heat shock proteins are also implicated in the impact of genital tract infections on the reproductive outcome, as well as in the local and systemic consequences of periodontal disease. Fever-range temperatures can induce the expression of heat shock proteins, and the final chapter in the book examines the influence of fever-range hyperthermia on a variety of cells and the organization of plasma membranes. This book is an essential read for graduates and postgraduates in Biology, pro- and eukaryotic Biochemistry, Immunology, Microbiology, Inflammatory and Infectious Disease, and Pathology.
Communicable diseases. --- Heat shock proteins. --- Prokaryotes --- Eukaryotic cells --- Heat shock proteins --- Communicable diseases --- Infection --- Molecular Chaperones --- Cells --- Stress, Physiological --- Eukaryotic Cells --- Communicable Diseases --- Prokaryotic Cells --- Heat-Shock Response --- Heat-Shock Proteins --- Physiological Processes --- Proteins --- Anatomy --- Bacterial Infections and Mycoses --- Diseases --- Amino Acids, Peptides, and Proteins --- Physiological Phenomena --- Phenomena and Processes --- Chemicals and Drugs --- Medicine --- Infectious Diseases --- Health & Biological Sciences --- Prokaryotes. --- Eukaryotic cells. --- Contagion and contagious diseases --- Contagious diseases --- Infectious diseases --- Microbial diseases in human beings --- Zymotic diseases --- Eucaryotic cells --- Monera --- Procaryotae --- Procaryotes --- Prokaryonta --- Prokaryotae --- Prokaryotic protists --- Stress proteins --- Medicine. --- Biomedicine. --- Biomedicine general. --- Epidemics --- Protista --- Microorganisms --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general. --- Biology --- Biomedical Research. --- Research. --- Biological research --- Biomedical research
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