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This book “Oxidative Stress Modulators and Functional Foods” is focused on the antioxidant role of natural products, involving their ability to modulate oxidative stress and/or reverse disease studied both in vitro and in animal models. Additionally, the molecular mechanisms of these actions and the modulation of signalling pathways related to inflammation, apoptosis, and survival response in the redox system by natural products are included.

Medicine --- Pharmaceutical industries --- high sugar-fat diet --- obesity --- β-adrenergic system --- cardiac dysfunction --- lycopene --- tomato-oleoresin --- coumarin --- pteryxin --- HO-1 --- Nrf2 --- oxidative stress --- Peucedanum japonicum Thunb --- RAW264.7 cells --- polysaccharide --- jujube pomace --- structural analysis --- antioxidant activity --- epigallocatechin-gallate --- liposomes --- diabetes mellitus --- antioxidant --- dendrimer --- electronic effect --- hydrogen atom transfer (HAT) --- single electron transfer-proton transfer (SET-PT) --- sequential proton loss electron transfer (SPLET) --- DPPH --- ultraviolet B --- gradient ethanol precipitation --- fucoidan --- HaCaT keratinocyte --- heme oxygenase-1 --- nutricosmetic --- folic acid --- nitric oxide --- neural tube defects --- NOR3 --- ESR --- LC/MS --- Benzo[a]pyrene --- myricetin --- BPDE-DNA adduct --- phase detoxifying enzyme --- Quamoclit angulata --- type 2 diabetes --- kidney damage --- inflammation --- apoptosis --- fibrosis --- Sargassum horneri --- (–)-loliolide --- fine dust --- HaCaT --- bilberry --- lingonberry --- polyphenols --- antioxidant compounds --- antimicrobial activity --- antimutagenicity --- altitude variations --- mitochondria --- neurodegeneration --- nutrient --- QM-ORSA --- antioxidative mechanisms --- reaction rate constants --- physiological conditions --- zebrafish embryo --- in vivo model --- antioxidant effect --- cudratrixanthone O --- reactive oxygen species --- nuclear transcription factor erythroid-2-like factor 2 --- hemeoxygenase-1 --- n/a --- (-)-loliolide

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This book “Oxidative Stress Modulators and Functional Foods” is focused on the antioxidant role of natural products, involving their ability to modulate oxidative stress and/or reverse disease studied both in vitro and in animal models. Additionally, the molecular mechanisms of these actions and the modulation of signalling pathways related to inflammation, apoptosis, and survival response in the redox system by natural products are included.

Medicine --- Pharmaceutical industries --- high sugar-fat diet --- obesity --- β-adrenergic system --- cardiac dysfunction --- lycopene --- tomato-oleoresin --- coumarin --- pteryxin --- HO-1 --- Nrf2 --- oxidative stress --- Peucedanum japonicum Thunb --- RAW264.7 cells --- polysaccharide --- jujube pomace --- structural analysis --- antioxidant activity --- epigallocatechin-gallate --- liposomes --- diabetes mellitus --- antioxidant --- dendrimer --- electronic effect --- hydrogen atom transfer (HAT) --- single electron transfer-proton transfer (SET-PT) --- sequential proton loss electron transfer (SPLET) --- DPPH --- ultraviolet B --- gradient ethanol precipitation --- fucoidan --- HaCaT keratinocyte --- heme oxygenase-1 --- nutricosmetic --- folic acid --- nitric oxide --- neural tube defects --- NOR3 --- ESR --- LC/MS --- Benzo[a]pyrene --- myricetin --- BPDE-DNA adduct --- phase detoxifying enzyme --- Quamoclit angulata --- type 2 diabetes --- kidney damage --- inflammation --- apoptosis --- fibrosis --- Sargassum horneri --- (-)-loliolide --- fine dust --- HaCaT --- bilberry --- lingonberry --- polyphenols --- antioxidant compounds --- antimicrobial activity --- antimutagenicity --- altitude variations --- mitochondria --- neurodegeneration --- nutrient --- QM-ORSA --- antioxidative mechanisms --- reaction rate constants --- physiological conditions --- zebrafish embryo --- in vivo model --- antioxidant effect --- cudratrixanthone O --- reactive oxygen species --- nuclear transcription factor erythroid-2-like factor 2 --- hemeoxygenase-1 --- high sugar-fat diet --- obesity --- β-adrenergic system --- cardiac dysfunction --- lycopene --- tomato-oleoresin --- coumarin --- pteryxin --- HO-1 --- Nrf2 --- oxidative stress --- Peucedanum japonicum Thunb --- RAW264.7 cells --- polysaccharide --- jujube pomace --- structural analysis --- antioxidant activity --- epigallocatechin-gallate --- liposomes --- diabetes mellitus --- antioxidant --- dendrimer --- electronic effect --- hydrogen atom transfer (HAT) --- single electron transfer-proton transfer (SET-PT) --- sequential proton loss electron transfer (SPLET) --- DPPH --- ultraviolet B --- gradient ethanol precipitation --- fucoidan --- HaCaT keratinocyte --- heme oxygenase-1 --- nutricosmetic --- folic acid --- nitric oxide --- neural tube defects --- NOR3 --- ESR --- LC/MS --- Benzo[a]pyrene --- myricetin --- BPDE-DNA adduct --- phase detoxifying enzyme --- Quamoclit angulata --- type 2 diabetes --- kidney damage --- inflammation --- apoptosis --- fibrosis --- Sargassum horneri --- (-)-loliolide --- fine dust --- HaCaT --- bilberry --- lingonberry --- polyphenols --- antioxidant compounds --- antimicrobial activity --- antimutagenicity --- altitude variations --- mitochondria --- neurodegeneration --- nutrient --- QM-ORSA --- antioxidative mechanisms --- reaction rate constants --- physiological conditions --- zebrafish embryo --- in vivo model --- antioxidant effect --- cudratrixanthone O --- reactive oxygen species --- nuclear transcription factor erythroid-2-like factor 2 --- hemeoxygenase-1

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Fucoidans are a group of fucose-containing sulfated polysaccharides found in many species of brown seaweeds, with numerous bioactive properties. As a highly bioactive seaweed substance with many promising physiological activities, fucoidans have attracted attention from many industries all over the world. Even though fucoidans are a rich source of bioactive properties, the structural properties and bioactive mechanisms of fucoidans are poorly understood. Therefore, novel studies that either characterize the physical properties or biological activities of fucoidans will fill the knowledge gap between industrial applications and the scientific background of those applications. Both purified and partially purified fucoidans isolated from brown seaweeds present high potential as preventative and therapeutic agents against number of chronic diseases, due to their anti-inflammatory, antioxidant, anticancer, neuroprotective, antiviral, antimicrobial, and anticoagulative properties. This Special Issue is aimed at presenting updated information on well-documented studies of the structural characterization and major biological actions relevant for medical, cosmeceutical, and pharmaceutical applications that fucoidans isolated from brown seaweed can offer.

fucoidan --- low-molecular-weight fucoidan --- adriamycin --- nephrotic syndrome --- psoriasis --- Traf3ip2 --- microbiota --- mucin --- IgA --- fucoidans --- extraction --- brown algae --- production --- bioactivities --- Sri Lankan algae --- anticancer --- sulfated polysaccharide --- Celluclast --- sargassum --- antioxidant --- Maldives --- Padina boryana --- zebrafish --- apoptosis --- DR4 --- mitochondrial pathway --- cancer --- metastasis --- epithelial mesenchymal transition --- nanoparticles --- Helicobacter pylori --- mozuku --- Cladosiphon okamuranus Tokida --- urinalysis --- fucose --- enzymatic purification --- age-related macular degeneration --- VEGF --- oxidative stress --- Laminaria digitata --- Fucus distichus subsp. evanescens --- Saccharina latissima --- retinal pigment epithelium --- ROS --- Phaeophyta --- carbohydrate --- UVB irradiation --- HaCaT cells --- sulfated heterosaccharide --- dopamine neurons apoptosis --- PI3K–Akt --- ascorbic acid --- anti-lung cancer --- human lung carcinoma A-549 cells --- hydrogen peroxide --- Sargassum crassifolium --- fucoidan from Ascophyllum nodosum --- postprandial hyperglycemia --- in vitro and in vivo evaluation --- SGLT1 --- chitosan --- fibroblast growth factor-2 --- polyelectrolyte multilayer --- infrared spectroscopy --- quartz crystal microbalance --- sulfated polysaccharides --- natural defenses --- phenolic metabolism --- phenylalanine ammonia-lyase --- n/a --- PI3K-Akt

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Cancer is the second leading cause of death worldwide, and was accountable for an estimated 9.6 million deaths in 2018. Nowadays, about 1 in 6 deaths in the world is due to cancer. Another major global public health issue is HIV. Over 70 million people have been infected with the HIV virus and about 35 million people have died of HIV-related illness, since the start of the epidemic. We have been fighting against these two serious diseases by finding successful treatments. The discovery of effective drugs is important for fighting cancer and HIV. Natural products, which are secondary metabolites produced by various living organisms, have been playing a principal role in drug discovery and developments, because of their structural and biological diversity. Many clinically used drugs have come from natural products; for example, more than 60% of anticancer drugs currently in clinical use are derived from natural sources. This Special Issue aims to collect original research and review articles focusing on notable and recent contributions to the discovery and development of novel anticancer and anti-HIV drug candidates from natural sources. Up-to-date knowledge from various research fields is welcome. This could be of great interest for scientists working in different research areas, such as natural product chemistry, including isolation and structural elucidation; phytochemistry; medicinal chemistry, including chemically modified natural compounds with improved biological activity; pharmacology; molecular biology; mechanisms of action study using natural products or related compounds; pharmacognosy, etc. Biological studies of natural extracts without an appropriate chemical characterization may not be considered.

Research & information: general --- natural phaeosphaeride A --- antitumor activity --- human tumor cell lines --- HEF cell line --- acute toxicity --- aspidosperma-type --- monoterpenoid indole alkaloids --- antiproliferative activity --- tubulin inhibitor --- Bousigonia mekongensis --- ursolic acid --- DOTA --- triterpenoids --- cytotoxicity --- diterpenoid alkaloids --- human tumor cells --- lipojesaconitine --- delcosine --- delpheline --- kobusine --- pseudokobusine --- BRAF inhibitor --- Mentha aquatica var. Kenting Water Mint --- essential oil --- chemoprevention --- two-stage skin carcinogenesis --- melanoma --- curcumin analog --- apoptosis --- oxidative stress --- drug–drug interaction --- tamoxifen --- taxol --- cisplatin --- Artemisia absinthium L. --- antioxidants --- total phenolic content --- melanoma and breast cancer cell line --- HaCaT cells --- inflammation --- breast cancer --- cell cycle --- flavonoids --- reactive oxygen species --- tumor suppression --- antiretroviral agents --- anti-HIV --- marine metabolites --- natural products --- drug development --- Ivalin --- Carpesium divaricatum --- hepatocellular carcinoma --- mitochondria-mediated apoptosis --- NF-κB --- Hernandia nymphaeifolia --- butanolides --- lignan glycosides --- coumarins --- antiangiogenic --- cancer --- natural agents --- chemistry --- medicine --- cancer stem cell --- cervical cancer --- pterostilbene --- resveratrol --- caffeic acid --- cancer multidrug resistance --- P-glycoprotein --- phenolic acid --- oxypeucedanin --- Angelica dahurica --- antiproliferation --- G2/M phase cell cycle arrest --- p53 --- SK-Hep-1 --- hepatoma cells --- allyl isothiocyanate --- benzyl isothiocyanate --- sulforaphane --- phenethyl isothiocyanate --- bladder cancer --- quercetin --- oral squamous cell carcinoma cells --- metastasis --- cell cycle arrest --- epithelial-to-mesenchymal transition --- matrix metalloproteinase --- transforming growth factor-β1 --- β-lapachone --- natural phaeosphaeride A --- antitumor activity --- human tumor cell lines --- HEF cell line --- acute toxicity --- aspidosperma-type --- monoterpenoid indole alkaloids --- antiproliferative activity --- tubulin inhibitor --- Bousigonia mekongensis --- ursolic acid --- DOTA --- triterpenoids --- cytotoxicity --- diterpenoid alkaloids --- human tumor cells --- lipojesaconitine --- delcosine --- delpheline --- kobusine --- pseudokobusine --- BRAF inhibitor --- Mentha aquatica var. Kenting Water Mint --- essential oil --- chemoprevention --- two-stage skin carcinogenesis --- melanoma --- curcumin analog --- apoptosis --- oxidative stress --- drug–drug interaction --- tamoxifen --- taxol --- cisplatin --- Artemisia absinthium L. --- antioxidants --- total phenolic content --- melanoma and breast cancer cell line --- HaCaT cells --- inflammation --- breast cancer --- cell cycle --- flavonoids --- reactive oxygen species --- tumor suppression --- antiretroviral agents --- anti-HIV --- marine metabolites --- natural products --- drug development --- Ivalin --- Carpesium divaricatum --- hepatocellular carcinoma --- mitochondria-mediated apoptosis --- NF-κB --- Hernandia nymphaeifolia --- butanolides --- lignan glycosides --- coumarins --- antiangiogenic --- cancer --- natural agents --- chemistry --- medicine --- cancer stem cell --- cervical cancer --- pterostilbene --- resveratrol --- caffeic acid --- cancer multidrug resistance --- P-glycoprotein --- phenolic acid --- oxypeucedanin --- Angelica dahurica --- antiproliferation --- G2/M phase cell cycle arrest --- p53 --- SK-Hep-1 --- hepatoma cells --- allyl isothiocyanate --- benzyl isothiocyanate --- sulforaphane --- phenethyl isothiocyanate --- bladder cancer --- quercetin --- oral squamous cell carcinoma cells --- metastasis --- cell cycle arrest --- epithelial-to-mesenchymal transition --- matrix metalloproteinase --- transforming growth factor-β1 --- β-lapachone

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• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cancer is the second leading cause of death worldwide, and was accountable for an estimated 9.6 million deaths in 2018. Nowadays, about 1 in 6 deaths in the world is due to cancer. Another major global public health issue is HIV. Over 70 million people have been infected with the HIV virus and about 35 million people have died of HIV-related illness, since the start of the epidemic. We have been fighting against these two serious diseases by finding successful treatments. The discovery of effective drugs is important for fighting cancer and HIV. Natural products, which are secondary metabolites produced by various living organisms, have been playing a principal role in drug discovery and developments, because of their structural and biological diversity. Many clinically used drugs have come from natural products; for example, more than 60% of anticancer drugs currently in clinical use are derived from natural sources. This Special Issue aims to collect original research and review articles focusing on notable and recent contributions to the discovery and development of novel anticancer and anti-HIV drug candidates from natural sources. Up-to-date knowledge from various research fields is welcome. This could be of great interest for scientists working in different research areas, such as natural product chemistry, including isolation and structural elucidation; phytochemistry; medicinal chemistry, including chemically modified natural compounds with improved biological activity; pharmacology; molecular biology; mechanisms of action study using natural products or related compounds; pharmacognosy, etc. Biological studies of natural extracts without an appropriate chemical characterization may not be considered.

Research & information: general --- natural phaeosphaeride A --- antitumor activity --- human tumor cell lines --- HEF cell line --- acute toxicity --- aspidosperma-type --- monoterpenoid indole alkaloids --- antiproliferative activity --- tubulin inhibitor --- Bousigonia mekongensis --- ursolic acid --- DOTA --- triterpenoids --- cytotoxicity --- diterpenoid alkaloids --- human tumor cells --- lipojesaconitine --- delcosine --- delpheline --- kobusine --- pseudokobusine --- BRAF inhibitor --- Mentha aquatica var. Kenting Water Mint --- essential oil --- chemoprevention --- two-stage skin carcinogenesis --- melanoma --- curcumin analog --- apoptosis --- oxidative stress --- drug–drug interaction --- tamoxifen --- taxol --- cisplatin --- Artemisia absinthium L. --- antioxidants --- total phenolic content --- melanoma and breast cancer cell line --- HaCaT cells --- inflammation --- breast cancer --- cell cycle --- flavonoids --- reactive oxygen species --- tumor suppression --- antiretroviral agents --- anti-HIV --- marine metabolites --- natural products --- drug development --- Ivalin --- Carpesium divaricatum --- hepatocellular carcinoma --- mitochondria-mediated apoptosis --- NF-κB --- Hernandia nymphaeifolia --- butanolides --- lignan glycosides --- coumarins --- antiangiogenic --- cancer --- natural agents --- chemistry --- medicine --- cancer stem cell --- cervical cancer --- pterostilbene --- resveratrol --- caffeic acid --- cancer multidrug resistance --- P-glycoprotein --- phenolic acid --- oxypeucedanin --- Angelica dahurica --- antiproliferation --- G2/M phase cell cycle arrest --- p53 --- SK-Hep-1 --- hepatoma cells --- allyl isothiocyanate --- benzyl isothiocyanate --- sulforaphane --- phenethyl isothiocyanate --- bladder cancer --- quercetin --- oral squamous cell carcinoma cells --- metastasis --- cell cycle arrest --- epithelial-to-mesenchymal transition --- matrix metalloproteinase --- transforming growth factor-β1 --- β-lapachone