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HSP70 Heat-Shock Proteins --- Protein Folding --- Transcription Factors --- Heat-Shock Response --- metabolism --- physiology

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This book presents the latest advances in assisted reproductive technologies applied to ruminants, such as multiovulation, artificial insemination, embryo transfer, and in vitro fertilization (IVF), which have been useful tools to accelerate the genetic progress in these species. The reader will find detailed studies on bisons, bovines, and goats

sperm viability --- embryo production --- fertilization --- blastocyst --- caprine --- COC --- IVF --- IVP --- IVEP --- oocyte competence --- photoperiod --- reproductive efficiency --- season --- seasonal breeder --- HSP70 --- heat stress --- in vitro embryos --- gene expression --- cattle --- Holstein --- Mediterranean Water Buffalo --- in vitro embryo production --- laparoscopic ovum pickup --- accelerated genetic gain --- prepubertal --- embryo development --- wisent --- European bison --- oocytes --- sperm --- embryos --- embryo transfer --- germplasm bank --- threatened species

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This book presents the latest advances in assisted reproductive technologies applied to ruminants, such as multiovulation, artificial insemination, embryo transfer, and in vitro fertilization (IVF), which have been useful tools to accelerate the genetic progress in these species. The reader will find detailed studies on bisons, bovines, and goats

Research & information: general --- Biology, life sciences --- Animals & society --- sperm viability --- embryo production --- fertilization --- blastocyst --- caprine --- COC --- IVF --- IVP --- IVEP --- oocyte competence --- photoperiod --- reproductive efficiency --- season --- seasonal breeder --- HSP70 --- heat stress --- in vitro embryos --- gene expression --- cattle --- Holstein --- Mediterranean Water Buffalo --- in vitro embryo production --- laparoscopic ovum pickup --- accelerated genetic gain --- prepubertal --- embryo development --- wisent --- European bison --- oocytes --- sperm --- embryos --- embryo transfer --- germplasm bank --- threatened species

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Immunohistochemistry (IHC) is an ancillary method, widely used in pathologists’ practice, that allows identifying diagnostic and prognostic/predictive of therapeutic response protein markers on tissue samples by the use of specific monoclonal antibodies and chromogenic substances that guarantee the visualization of an antibody–antigene binding complex under a light microscope [1]. Coon et al., in 1941 [2], first introduced the use of fluorochrome-conjugated antibodies in clinical practice. Since then, IHC has gone from being a useful tool for identifying the differentiation line of otherwise undifferentiated cells to a technique capable of providing not only diagnostic but also prognostic and predictive indications of responses to specific therapeutic options [1,3]. The abovementioned peculiarities have made IHC one of the most used ancillary methods in the histopathological approach to human neoplastic and non-neoplastic diseases [3-5]. This Special Issue contains 11 accepted papers that provide readers with a comprehensive update on current and future applications of IHC in medical practice.

training exercise --- NGAL --- VDR --- kidney --- heart --- immunohistochemistry --- ABCB5 --- uveal melanoma --- prognosis --- metastasis --- pericardium --- cytokeratin --- c-kit --- PDGFR --- initial lymphatics --- macroH2A --- prognostic factor --- SLC22A12 --- URAT1 --- hypouricemia --- uric acid transporters --- excretion fraction of uric acid --- Hsp27 --- Hsp60 --- Hsp70 --- Hsp90 --- molecular chaperone --- chaperonopathies --- thyroid --- follicular adenoma --- follicular carcinoma --- differential diagnosis --- carcinogenesis --- matrix metalloproteinases --- temporomandibular joint disorder --- temporomandibular joint --- DEN --- liver --- inflammation --- ultra-structural changes --- oxidative stress --- EGCG --- Vitamin D --- prostate cancer --- urinary tract malformations --- megacystis --- enteric nervous system --- outcome and prognosis --- WT1 --- human embryonal/fetal tissues --- neoplastic tissue --- n/a

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Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for "canonical", TRPA with A for "ankyrin", TRPM with M for "melastatin", TRPML with ML for "mucolipidin", TRPP with P for "polycystin", and TRPV with V for "vanilloid". Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in "Cells" summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options.

n/a --- transient receptor potential channels --- photochromic ligands --- elementary immunology --- Purkinje cell --- EPSC --- substance P --- chemicals --- organ toxicity --- lymphocytes --- HSP70 --- physiology --- bioavailable --- inflammatory bowel disease --- platelets --- pollutants --- yeast --- regulatory T cells --- kinase --- Saccharomyces cerevisiae --- manganese --- cerebellum --- TRP channel --- NHERF --- inflammation --- nanoHPLC-ESI MS/MS --- TRPM7 --- chemical probes --- TRPM8 --- dorsal column nuclei --- TRPV2 --- TRPV3 --- calcitonin gene-related peptide --- TRPV1 --- ion channels --- transient receptor potential --- 2D gel electrophoresis --- MALDI-TOF MS(/MS) --- TRPV4 --- overproduction --- sulfur mustard --- oxidative stress --- graft versus host disease --- menthol --- topical --- chemosensor --- AP18 --- calcium signalling --- mucosal epithelium --- cuneate nucleus --- production platform --- TRPC channels --- ulcerative colitis --- channel structure --- xerostomia --- neutrophils --- cardiovascular system --- TRPC5 --- TRPC6 --- TRPC3 --- TRPC4 --- calcium signaling --- protein purification --- adipose tissue --- transient receptor potential (TRP) channels --- sodium --- TH17 --- diacylglycerol --- hypersensitivity --- TRPY1 --- GABAB --- HEK293 --- thrombosis --- ion channel --- TRPC --- pathophysiology --- SMAD --- toxicology --- endothelium --- calcium --- proteomics --- TRPA1 --- salivary glands --- TRP channels --- lipid mediators --- sensors --- radiation --- TRPM4 channel --- human medulla oblongata --- mGluR1 --- small molecules --- TRPC3 pharmacology