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Anti-social behaviors and social deficits induced mental disorders are critical problems in our society today. Social behaviors and interactions are shaped by experience, hereditary components (genes, hormones and neuropeptides) and environmental factors (photoperiods and metabolic signals). In addition to the classical gonadotropin-releasing hormone, RFamide peptides, kisspeptin and gonadotropin-inhibiting hormone are emerging as important regulators of the reproductive axis. These neuropeptides are evolutionarily conserved and are regulated by environmental factors. In this Research Topic, we advocate more recent advances in reproductive neuropeptides and sex steroids in the domains of social behavior including sexual and parental behavior, aggression, stress and anxiety. Using multiple species model, we also review how genes and the neuroendocrine system interact at the cell and organismic levels to contribute to social behavior in particular the epigenetic genomic changes caused by early life environment. We provide comprehensive insights of distinct neural networks and how cellular and molecular events in the brain regulate social behavior from a comparative perspective.

sex steroids --- HPG axis --- Reproduction --- Oxytocin --- Aggression --- vasopressin --- Behavior --- GnRH --- neurotransmitter --- social bonding

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This Special Issue highlights the most recent research on depression, anxiety and dementia, with attention to comorbidity in a range of diseases. The symptoms of depression, anxiety and dementia are the most common comorbid manifestations present in patients suffering from neurodegenerative and psychiatric diseases. Together, these illnesses constitute an extremely complex and challenging research field due to their inherent multifactorial causative factors, heterogeneous pathogenesis, and mental and behavioral manifestations. This Special Issue covers laboratory, clinical and statistical studies on the crosstalk between depression, anxiety, dementia, Alzheimer’s disease, multiple sclerosis, schizophrenia, diabetes mellitus, Down’s syndrome, and/or compulsive disorders. It contains contributions from 71 authors, has been reviewed by 25 referees, and edited by three academic editors and one managing editor.

Medicine --- Clinical & internal medicine --- dementia --- behavioral and psychological symptoms of dementia --- systematic review --- meta-analysis --- animal-assisted intervention --- pet-robot intervention --- G protein-coupled receptors --- GPR120 --- FFAR4 --- schizophrenia --- polyunsaturated fatty acids --- long-chain fatty acids --- omega-3 --- nutritional psychiatry --- Alzheimer’s disease --- psychiatric disease --- depression --- anxiety --- Down’s syndrome --- inositol --- nutraceutical --- insulin signaling --- antioxidant --- aging --- psilocybin --- clinical trials --- oxidative stress --- redox --- multiple sclerosis --- biomarker --- neurodegenerative disease --- personalized medicine --- major depressive disorder --- longitudinal study --- LC-MS/MS --- plasma protein biomarker --- drug response monitoring --- multiple reaction monitoring --- diabetes mellitus --- type 2 --- dyslipidemias --- hypertension --- post-stroke depression --- disability level --- mortality --- late-life depression --- neuroimaging --- resting-state functional magnetic resonance imaging --- default mode network --- executive control network --- salience network --- healthy life expectancy (HALE) --- morbidity/mortality paradox --- cognition --- systolic blood pressure --- cerebral blood flow --- arterial properties --- angiogenesis --- gender medicine --- neurodegenerative disorders --- kisspeptin --- locomotion --- Kiss1 receptor --- HPA axis --- HPG axis --- nucleus accumbens --- stroke --- lipid --- diabetes

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This Special Issue highlights the most recent research on depression, anxiety and dementia, with attention to comorbidity in a range of diseases. The symptoms of depression, anxiety and dementia are the most common comorbid manifestations present in patients suffering from neurodegenerative and psychiatric diseases. Together, these illnesses constitute an extremely complex and challenging research field due to their inherent multifactorial causative factors, heterogeneous pathogenesis, and mental and behavioral manifestations. This Special Issue covers laboratory, clinical and statistical studies on the crosstalk between depression, anxiety, dementia, Alzheimer’s disease, multiple sclerosis, schizophrenia, diabetes mellitus, Down’s syndrome, and/or compulsive disorders. It contains contributions from 71 authors, has been reviewed by 25 referees, and edited by three academic editors and one managing editor.

Medicine --- Clinical & internal medicine --- dementia --- behavioral and psychological symptoms of dementia --- systematic review --- meta-analysis --- animal-assisted intervention --- pet-robot intervention --- G protein-coupled receptors --- GPR120 --- FFAR4 --- schizophrenia --- polyunsaturated fatty acids --- long-chain fatty acids --- omega-3 --- nutritional psychiatry --- Alzheimer’s disease --- psychiatric disease --- depression --- anxiety --- Down’s syndrome --- inositol --- nutraceutical --- insulin signaling --- antioxidant --- aging --- psilocybin --- clinical trials --- oxidative stress --- redox --- multiple sclerosis --- biomarker --- neurodegenerative disease --- personalized medicine --- major depressive disorder --- longitudinal study --- LC-MS/MS --- plasma protein biomarker --- drug response monitoring --- multiple reaction monitoring --- diabetes mellitus --- type 2 --- dyslipidemias --- hypertension --- post-stroke depression --- disability level --- mortality --- late-life depression --- neuroimaging --- resting-state functional magnetic resonance imaging --- default mode network --- executive control network --- salience network --- healthy life expectancy (HALE) --- morbidity/mortality paradox --- cognition --- systolic blood pressure --- cerebral blood flow --- arterial properties --- angiogenesis --- gender medicine --- neurodegenerative disorders --- kisspeptin --- locomotion --- Kiss1 receptor --- HPA axis --- HPG axis --- nucleus accumbens --- stroke --- lipid --- diabetes