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This third volume of "Uveitis and Immunological Disorders" in Essentials in Ophthalmology provides up-to-date, relevant information for the reader. Our knowledge and understanding of immune mechanisms has increased exponentially over the past few years and has expanded to disorders such as diabetic retinopathy and macular degeneration. This volume will provide the ophthalmologist with practical information on how to diagnose and treat these difficult, and in some cases, blinding disorders. In addition, there are important discussions of the mechanisms underlying these conditions, which incorporate the most recent, up-to-date research material available. "Summary for the Clinician" and "Core Messages" sections enhance the value of each chapter. This volume was written by authors who are leaders in their field. Important and provocative questions dealing with recent developments are raised. Topics covered include: To do or not to do? HLA typing in keratoplasty Acute anterior uveitis and HLA-B27: what is new? Keratouveitis: new aspects on diagnosis and management Steroid sensitivity in uveitis Is Behcet’s retinal vasculitis different from idiopathic retinal vasculitis? Is the diagnosis important in sight-threatening non-infectious uveitis? Uveitis and multiple sclerosis: is there a real link? Inflammation and AMD: what is the evidence? Diabetic retinopathy: an inflammatory disorder? Pathophysiology and its consequences. This highly practical and clinically relevant volume is valuable to all those involved in the handling and treatment of patients with ocular inflammation. In addition, it provides fresh perspectives and insights into our current understanding of common disorders such as diabetic retinopathy and macular degeneration.

Eye -- Diseases -- Immunological aspects. --- Eye -- Immunology. --- Eye Diseases -- immunology. --- Eye Diseases -- physiopathology. --- Eye Diseases -- therapy. --- Uveitis -- immunology. --- Uveitis. --- HLA-B27 Antigen --- Eye Diseases --- Uveitis --- HLA-B Antigens --- Uveal Diseases --- Diseases --- HLA Antigens --- Histocompatibility Antigens Class I --- Histocompatibility Antigens --- Antigens, Surface --- Isoantigens --- Antigens --- Biological Factors --- Chemicals and Drugs --- Ophthalmology & Optometry --- Medicine --- Health & Biological Sciences --- Eye --- Immunological aspects. --- Eyeball --- Eyes --- Visual system --- Uvea --- Inflammation --- Medicine. --- Ophthalmology. --- Medicine & Public Health. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Face --- Photoreceptors --- Vision

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Adverse drug reactions are one of the major constraints when using drugs. These adverse reactions can impact healthcare systems as strongly as many prevalent diseases. Identifying DNA variants associated with adverse drug reactions can help personalize medicine and sustain healthcare systems. This book delves into new advances in pharmacogenetics of cardiovascular, cancer, and nervous system drugs. It may be useful for clinicians and patients to understand the basics of pharmacogenetics.

5-fluorouracil --- capecitabine --- fluoropyrimidine --- thymidylate synthase --- thymidylate synthase enhancer region --- upstream stimulatory factor 1 --- adverse drug reactions --- pharmacogenomics --- epistasis --- random forest --- statin --- cardiovascular disease --- colorectal cancer --- personalised medicine --- toxicity --- (es)citalopram --- drug-gene-interaction --- drug-drug-interaction --- drug-drug-gene-interaction --- the PharmLines initiative --- antipsychotic agents --- pharmacogenetics --- cytochrome P-450 enzyme system --- psychotic disorders --- precision medicine --- direct oral anticoagulants --- clinical implementation --- atorvastatin --- SLCO1B1 --- HLA --- cutaneous adverse drug reaction --- SCAR --- genetic polymorphism --- antiepileptics --- CYP450 enzymes --- platelet reactivity --- single-nucleotide variants --- acute coronary syndrome --- clopidogrel --- genotype --- allele --- polymorphism --- HLA B --- CYP2C9*3 --- cutaneous adverse drug reactions (CADRs) --- anti-epileptic drugs (AEDS) --- phenytoin (PHT) --- genetic risk factors --- South India --- India --- cardiology --- adverse events --- guidelines --- n/a

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A Special Issue in memory of Randall J. Cohrs, Ph.D. Topics include original research reports on a variety of viruses as well as reviews and commentaries on Randy’s contributions to many investigations.

Research & information: general --- Biology, life sciences --- varicella-zoster virus --- Oka strain --- human herpesvirus 6 --- human herpesvirus 7 --- corticosteroids --- serious adverse event --- herpes zoster --- IL-6 --- IL-10 --- innate immunity --- VLT --- VLT-ORF63 --- CRISPR/Cas9 --- BAC mutagenesis --- flavivirus --- SARS-CoV-2 --- pandemic preparedness --- host–virus interactions --- prion --- vaccines --- interferon lambda --- virus --- herpes simplex virus type 1 --- herpes simplex virus type 2 --- neonatal herpesvirus infection --- HSV UL6 --- herpesvirus encephalitis --- herpesvirus hepatitis --- acyclovir --- HerpeSelect test --- viral sequencing --- HELLP syndrome --- lipids --- dengue virus --- acyl-CoA --- acyl-CoA thioesterase --- fatty acids --- membranes --- rheostat --- fatty acyl-CoA --- Marek’s disease virus --- live-cell genome visualization --- lytic replication --- T cells --- latency --- genome integration --- TetO/TetR system --- varicella zoster virus --- reactivation --- genome cleavage --- AAV --- antiviral therapies --- HSV-1 --- cornea --- trigeminal ganglia --- interferon-γ --- interferon stimulatory genes --- TRIM21 --- HSV --- EBV --- KSHV --- MHV68 --- PIC --- transcription --- productive elongation --- mRNA --- rRNA --- tRNA --- herpes --- viral reactivation --- spaceflight --- dermatitis --- stress --- immune depression --- antiviral drugs --- bacterial artificial chromosome --- luciferase --- bioluminescence imaging --- skin organ culture --- humanized mice --- β-Coronavirus --- mouse hepatitis virus-A59/MHV-A59 --- mouse hepatitis virus-2/MHV2 spike protein --- fusion peptide/FP --- cell-to-cell fusion (fusogenicity) --- neuropathogenesis --- hepatitis --- demyelination --- structural rigidity --- simian varicella virus --- herpesvirus --- varicella --- VZV --- neuro-attenuated --- ORF7 --- vaccine --- n/a --- antiviral --- COVID-19 --- drug discovery --- coronavirus --- spike protein --- Mpro --- RdRp --- PLpro --- skin --- epidermis --- keratinocytes --- epidermal differentiation --- cutaneous blistering lesions --- keratins --- autophagy --- immunity --- human neuron culture --- non-coding RNA --- CD8 T cell --- T-cell epitope --- NK cell --- KIR3DL1 --- HLA-B*57:01 --- herpes simplex virus --- zoster --- skin pathogenesis --- HSV-2 --- neurons --- cell culture --- varicella-zoster --- gene expression --- ganglion --- autopsy --- saliva --- salivary VZV DNA --- dengue viruses --- Aedes aegypti --- adaptive mutation --- host-virus interactions --- Marek's disease virus